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| 1 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
| 2 | Unraveling the dose-response puzzle of L.monocytogenes:A mechanistic approach显示文摘Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally.To explore the threat L.monocytogenes presents to the elderly,pregnant woman and immuno-compromised individuals,many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes.However,the connection of these two foci has received little attention,leaving risk prediction with an insufficient mechanistic basis.Consequently,there is a critical need to quantifiably link in-host infection pathways with the doseresponse paradigm.To better understand these relationships,we propose a new mathematical model to describe the gastro-intestinal pathway of L.monocytogenes within the host.The model dynamics are shown to be sensitive to inoculation doses and exhibit bistability phenomena.Applying the model to guinea pigs,we show how it provides useful tools to identify key parameters and to inform critical values of these parameters that are pivotal in risk evaluation.Our preliminary analysis shows that the effect of gastroenvironmental stress,the role of commensal microbiota and immune cells are critical for successful infection of L.monocytogenes and for dictating the shape of the doseresponse curves. | S.M.Ashrafur Rahman Daniel Munther Aamir Fazil Ben Smith Jianhong Wu | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 3 | Synthesis, characterization and cytotoxicity of novel modified poly[(maleic anhydride)‐ co ‐(vinyl acetate)]/noradrenaline conjugate显示文摘 | Gulderen Karakus Zubeyde Akin Polat Ali Fazil Yenidunya Haci Bayram Zengin Can Bulent Karakus | 2012 | Polym. Int2012，，3： | 1 |
| 4 | Effect of cement on emulsified asphalt mixtures显示文摘 | SEREF Oruc FAZIL Celik AKPINAR M Vefa | 2007 | Journal of Materials Engineering and Performance2007，16，5： | 1 |
| 5 | Quality-Speed Conundrum: Trade-offs in Customer-Intensive Services 显示文摘 | KRISHNAN S A FAZIL M SENTHIL V | 2011 | Management Science2011，57，1： | 1 |
| 6 | Effect of cement on emulsified as- phalt mixtures显示文摘 | Seref O Fazil C | 2007 | Journal of Materials Engineering and Performance2007，16，2： | 1 |
| 7 | Evaluation of protective effect of Sapindus mukorossi saponin fraction on CCI4 - induced acute hepatotoxicity in rats 显示文摘 | M Sfinivasa Rao B Syed Asad MA Fazil | 2012 | Clinical and Experimental Gastroenterology2012，5，7： | 1 |
| 8 | Extraction of biomarkers from sediments with supercritical carbon dioxide: A comparative study with solvent extraction and thermodesorption methods 显示文摘 | Hopfgartner G rard Veuthey Jean-Luc Fazil O G la ar Armand Buehs | 1990 | Organic Geochemitry1990，15，： | 1 |
| 9 | Effect of cement on emulsified asphalt mixtures显示文摘 | ORUC Seref CELIK Fazil EFA AKPINAR M | 2007 | Journal of Materials Engineering and Performance2007，16，5： | 1 |
| 10 | Effect of cement on emulsified asphalt mixtures显示文摘 | SEREF O FAZIL C AKPINAR M V | 2007 | Journal of Materials Engineering and Performance2007，16，5： | 1 |
| 11 | Economic Growth and E- lectricity Consumption显示文摘 | Melike E Bildirici Fazil Kayikci | 2012 | Former Soviet Republics2012，，3： | 1 |
| 12 | Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting显示文摘 | Fazil M Md S Haque S | 2012 | Eur J Pharm Sci2012，47，1： | 1 |
| 13 | Coment on adaptive fading kalman filter with an application显示文摘 | Levent Ozbek Aliev Fazil A | 1998 | Aautomatica1998，34，12： | 1 |
| 14 | Antiplane shear crack problem in bonded materials with a nonhomogeneous interfacial zone 显示文摘 | Murat Ozturk Fazil Erdogan | 1991 | J Appl Mech1991，58，： | 1 |
| 15 | EDAX versus FTIR in mixed stones显示文摘 | Fazil Marickar YM Lekshmi PR Varma L | 2009 | Urol Res2009，37，： | 1 |
| 16 | Nanotherapeutics for Alzheimer's disease (AD): past, present and future显示文摘 | Fazil M Shadab Baboota S | 2012 | J Drug Target2012，20，2： | 1 |
| 17 | Optimum Design of Composite Laminates for Maximum Buckling Load Capacity Using Simulated Annealing 显示文摘 | Ozgur Erdal Sonmez Fazil O | 2005 | Composite Structures2005，71，： | 1 |
| 18 | EDAX versus FTIR in mixed stones显示文摘 | FAZIL MARICKAR YM LEKSHMI PR VARMA L | 2009 | Urol Res2009，37，5： | 1 |
| 19 | Effect of cement on emulsified asphalt mixtures显示文摘 | Seref O Fazil C Vefa A M | 2007 | Journal of Materials Engineering and Performance2007，16，： | 1 |
| 20 | Design of fiber reinforced laminates for maximum fatigue life显示文摘 | Ertas Ahmet H Sonmez Fazil O | 2010 | Procedia Eng2010，2，1： | 1 |
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