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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Pediatric skeletal trauma: use of multi planar reformatted and three -dimensional 64 -row multidetector CT in the emergency department 显示文摘 | Fayad LM Corl F Fishman EK | 2009 | Radiographies2009，29，1： | 1 |
| 3 | Relation of inflammatory modic changes to intradiscal steroid injection outcome in chronic low back pain 显示文摘 | Fayad F Lefevre-Colau M M Rannou F | 2007 | European Spine Journal2007，16，7： | 1 |
| 4 | R-HCVAD/R-MTX-ARAC is an effective regimen for untreated diffuse large B-cell lymphoma(DLBCL)with aggressive features in patients younger than 60 years显示文摘 | Fayad L Pro B Hagemeister F | 2007 | Blood2007，110，11： | 1 |
| 5 | CyberKnife radiosurgery for stage 1 lung cancer:results at 36 months显示文摘 | Brown WT Wu XD Fayad F | 2007 | Clinical Lung Cancer2007，8，8： | 1 |
| 6 | Sihuximab, a novel anti- interleukin-6 monoclonal antibody, for Castleman's disease 显示文摘 | Van Rhee F Fayad L Voorhees P | 2010 | J Clin Oncol2010，28，23： | 1 |
| 7 | Histopathology after en- dolymphatic sac surgery for M6nire' s syndrome 显示文摘 | Chung JW Fayad J Linthieum F | 2011 | Otology &Neurotology2011，32，4： | 1 |
| 8 | Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase 1/11 results显示文摘 | Morschhauser F Leonard JP Fayad L | 2009 | J Clin Oncol2009，27，20： | 1 |
| 9 | Relation of inflammatory modic changes to intradiscal steroid injection outcome in chronic low back pain显示文摘 | Fayad F Lefevre-Colau MM Rannou F | | 0，，07： | 1 |
| 10 | CyberKnife radiosurgery for stage I lung cancer:results at 36 months显示文摘 | Brown WT Wu X Fayad F | 2007 | Clin Lung Cancer2007，8，8： | 1 |
| 11 | Multichannel cochlear implants:relation of histopathology to performance显示文摘 | FAYAD J N LINTHICUM F H Jr | 2006 | Laryngoscope2006，116，： | 1 |
| 12 | Pediatric skeletal trauma:use of multi planar reformatted and three-dimensional 64-row multi-de tector CT in the emergency department显示文摘 | Fayad LM Corl F Fishman EK | 2009 | Radiographics2009，29，1： | 1 |
| 13 | Humanized anti- CD20 antibody, vehuzumab, in refractory/recurrent non- Hodgkin' s lymphoma: Phase Ⅰ/Ⅱ results 显示文摘 | Morschhauser F Leonard JP Fayad L | 2009 | J Clin Oncol2009，27，10： | 1 |
| 14 | Individualized higher dose of 70-75 Gy using five-fraction robotic stereotactic radiotherapy for non-small-cell lung cancer:a feasibility study显示文摘 | Brown WT Fayad F Hevezi J | | 0，，01： | 1 |
| 15 | Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase Ⅰ/Ⅱ results显示文摘 | Morschhauser F Leonard JP Fayad L | 2009 | J Clin Oncol2009，27，20： | 1 |
| 16 | Reliability, validity and responsiveness of the French version of the questionnaire Quick Disability of the Ann, Shoulder and Hand in shoulder disorders显示文摘 | Fayad F Lefevre-Colau MM Gautheron V et 01 | 2009 | Man Ther2009，14，2： | 1 |
| 17 | Reliability of amodified Modie classification of bone marrow changes in lumbar spine MRI 显示文摘 | Fayad F Lefevre -Colau MM Drape JL | 2009 | Joint Bone Spine2009，76，3： | 1 |
| 18 | Reliability of a modified Medic classification of bone marrow changes in lumbar spine MRI 显示文摘 | Fayad F Lefevre-Colau MM Drape JL | 2009 | Joint Bone Spine2009，76，3： | 1 |
| 19 | Intradiscal oorticosteroid injec- tions in spondylotic cervical radiculopathy 显示文摘 | Fayad F Rannou F Drape JL | 2007 | Eur Radiol2007，17，5： | 1 |
| 20 | Intradiscal corticosteroid injections in spondylotic cervical radiculopathy显示文摘 | Fayad F Rannou F DrapéJL | 2007 | Eur Radiol2007，17，5： | 1 |
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