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1篇 您的检索式:作者名="Fathi H.Assaleh"
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1In vitro–in vivo studies of the quantitative effect of calcium,multivitamins and milk on single dose ciprofloxacin bioavailability显示文摘Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies(IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins,calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.Baishakhi Dey Prakash Katakam Fathi H.Assaleh Babu Rao Chandu Shanta Kumari Adiki Analava Mitra 2015Journal of Pharmaceutical Analysis2015,5,6:1
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