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| 1 | Chronic hepatitis B: Advances in treatment显示文摘Treatment of chronic hepatitis B(CHB) has markedly improved in the last 15 years due to the availability of direct antivirals which greatly increase therapeutic options. Currently, there are two classes of agents licensed for CHB treatment: standard or pegylated interferon alpha(IFN or Peg-IFN) and five nucleoside/nucleotide analogues(NAs). Long-term treatment with NAs is the treatment option most often used in the majority of CHB patients. Entecavir and tenofovir, the most potent NAs with high barrier to resistance, are recommended as first-line monotherapy by all major treatment guidelines and can lead to long-lasting viro-logical suppression, resulting in histological improve-ment or reversal of advanced fibrosis and reduction in disease progression and liver-related complications. In this review, we focus on current treatment strategies of chronic hepatitis B and discuss the most recent efficacy and safety data from clinical trials and real life clinical practice. Recent findings of response-guided approach-es are also discussed. | Teresa Antonia Santantonio Massimo Fasano | 2014 | World Journal of Hepatology2014，6，5： | 12 |
| 2 | Role of Arabidopsis UV RESISTANCE LOCUS 8 in Plant Growth Reduction under Osmotic Stress and Low Levels of UV-B显示文摘在热点环境,植物暴露于压力的不同类型,例如触发普通 morphogenic 的 UV-B,而且 droughtstress 的过量适应反应导致植物生长的一般减小。这里,我们 reportthat Arabidopsis thaliana 紫外抵抗地点 8 (UVR8 ) 基因, UV-B morphogenic 反应的一个已知的管理者,能补充 Saccharomyces cerevisiae osmo 敏感的异种和它的表示在 Arabidopsis 植物在渗透或咸的应力以后被导致。在 UV-B 的底层下面,植物 overexpressing UVR8 与减少的根开发被相形见绌并且与控制植物相比积累更多的 flavonoids。生长 defectsare 主要由于细胞扩大的抑制。UVR8 overexpression 在 UV-B 的底层下面在植物触发的生长抑制被导致甘露糖醇的渗透的应力加重,但是它不是由离子的应力的 significantlyaffected。相反, uvr8-6 异种植物不在标准条件下面不同于野类型的植物,但是他们显示出一个增加的射击生长 underhigh 盐压力。我们的数据建议 flavonoid 并且可能的调停 UVR8 的累积在植物生长素 homeostasisare 改变观察生长显型的内在的机制并且 UVR8 可能为 integratingplant 生长和压力 signals.Key 词有一个重要角色: | Rossella Fasano Nathalie Gonzalez Alessandra Tosco Fabrizio Dal Piaz Teresa Docimo Ramon Serrano Stefania Grillo Antonella Leone Dirk Inze | 2014 | Molecular Plant2014，7，5： | 7 |
| 3 | Acute hepatitis C: clinical and laboratory diagnosis, course of the disease, treatment显示文摘 | E. Sagnelli T. Santantonio N. Coppola M. Fasano M. Pisaturo C. Sagnelli | 2014 | Infection2014，，4： | 2 |
| 4 | Combined airways: impact of upper airways on lower airway显示文摘 | Fasano MB | 2010 | Curr Opin Otolaryngol Head Neck Surg2010，18，1： | 1 |
| 5 | Denaturing high-perform- ance liquid chromatography in the detection of ABCA1 gene mutations in familial HDI deficiency显示文摘 | Fasano T Bocchi L Pisciotta L | 2005 | J Lipid Res2005，46，4： | 1 |
| 6 | Surgical treatment of spasticity in cerebral palsy显示文摘 | Fasano VA Broggi G Barolat-Romana G | 1978 | Child Brain1978，4，5： | 1 |
| 7 | Leaky gut and autoimmune diseases显示文摘 | Fasano A | 2012 | Clinical Reviews in Allergy&Immunology2012，42，1： | 1 |
| 8 | Electrophysiological assessment of spinal circuits in spasticity by direct dorsal root stimalatation 显示文摘 | Fasano VA Barolat-Romana G Zemes | 1979 | Neurosuiery1979，4，： | 1 |
| 9 | Surgical treatment of spasticity of cerebral palsy显示文摘 | FASANO VA BROGGI G BAROLAT ROMANA G | 1978 | Childs Brain1978，4，： | 1 |
| 10 | Zonulin and its regulation of intestinal barrier function:the biological door to inflammation,autoimmunity,and cancer显示文摘 | Fasano A | 2011 | Physiological Reviews2011，91，1： | 1 |
| 11 | Di (2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) exposure through diet in hospital patients 显示文摘 | Cirillo T Fasano E Esposito F | 2013 | Food and Chemical Toxicology2013，51，： | 1 |
| 12 | Shigella enterotoxin 1 : an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro显示文摘 | Fasano A Noriega FR Maneval DR Jr | 1995 | J Clin Invest1995，95，： | 1 |
| 13 | Mechanisms of disease:the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases显示文摘 | Shea-Donohue T | 2005 | Nat Clin Pract Gastroenterol Hepatol2005，2，9： | 1 |
| 14 | Intratesticular feedback mechanisms in the regulation of steroid profiles in the frog,Rana esculenta显示文摘 | Fasano S Minucci S Di Matteo L | 1989 | Gen Comp Endocrinol1989，75，3： | 1 |
| 15 | A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol 显示文摘 | Fasano T Cefalu A B Di Leo E | 2007 | Arterioscler Thromb Vasc Biol2007，27，3： | 1 |
| 16 | Epiphrenic Diverticu- lum:Clinical and Radiographic Findings in 27 Patients 显示文摘 | Fasano NC Levine MS Rubesin SE | 2003 | Dys-pha- gia2003，18，1： | 1 |
| 17 | Breast feeding, bottle feeding, and non-nutritive sucking; effects on occlusion in deci- duous dentition显示文摘 | Viggiano D Fasano D Monaco G | 2004 | Arch Dis Child2004，89，12： | 1 |
| 18 | Lysosomal lipase deficiency:molecular characterization of eleven patients with Wolman or cholesteryl ester storage disease显示文摘 | Fasano T Pisciotta L Bocchi L | | 0，，03： | 1 |
| 19 | Particle swarm optimization with non-smooth penalty reformulation, for a complex portfolio selection problem显示文摘 | Corazza M Fasano G Gusso R | 2013 | Applied Mathematics and Computation2013，224，1： | 1 |
| 20 | The extraordinary ligand binding prop- erties of human serum albumin 显示文摘 | Fasano M Curry S Terreno E | 2005 | IUBMB Life2005，57，12： | 1 |
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