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| 1 | Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies显示文摘BACKGROUND Recurrent acute pancreatitis(RAP)may be a presenting feature of and an indication for resection of pancreatic cysts,including intra-ductal papillary mucinous neoplasm(IPMN).Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.AIM To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy.METHODS This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasms at a university hospital between 2002 and 2016.The prevalence of preoperative high-risk cyst features,and of neoplasia was compared between patients with and without RAP.To identify the cause of pancreatitis,all the patients had a detailed history of alcohol,smoking,medications obtained,and had cross-sectional imaging(contrast-enhanced computed tomography/magnetic resonance imaging)and endoscopic ultrasound to look for gallstone etiology and other structural causes for pancreatitis.The incidence of RAP post-resection was the primary outcome.RESULTS IPMN accounted for 101 cases(58.7%){[branch duct(BD)59(34.3%),main duct(MD)42](24.4%)}.Twenty-nine(16.9%)presented with RAP(mean 2.2 episodes):15 had BD-IPMN,8 MD-IPMN,5 mucinous cystic neoplasm and 1 serous cystic neoplasm.Malignancy was similar among those with vs without RAP for all patients[6/29(20.7%)vs 24/143(16.8%)]and IPMN patients[6/23(26.1%)vs 23/78(29.5%)],although tended to be higher with RAP in BD-IPMN,[5/15(33.3%)vs 3/44(6.8%),P=0.04].At mean follow-up of 7.2 years,1(3.4%)RAP patient had post-resection RAP.The mean episodes of acute pancreatitis before vs after surgery were 3.4 vs 0.02(P<0.0001).CONCLUSION Malignancy was not increased in patients with pancreatic cystic neoplasms who have RAP compared to those without RAP.In addition,specific cyst characteristics were not clearly associated with RAP.The incidence of RAP was markedly decreased in almost all patients following cyst resection. | Thiruvengadam Muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem | 2021 | World Journal of Gastroenterology2021，27，15： | 3 |
| 2 | Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2B epsilon mRNA in a mammalian target of rapamycin-dependent manner 显示文摘 | Kubica N Bolster D R Farrell P A | 2005 | J Biol Chem2005，280，9： | 1 |
| 3 | The structure of the internal wave Mach front generated by a point source moving in a stratified fluid显示文摘 | Gray E P Hart R W Farrell R A | 1983 | Physics of Fluids (1958-1988)1983，26，10： | 1 |
| 4 | Deformation behavior of W-Cu composites显示文摘 | EDWARDS M R FARRELL W J | 1993 | Powder Metallurgy1993，36，4： | 1 |
| 5 | The Matching Polynomials of a Regular Graphs显示文摘 | BEEZET R A FARRELL E J | 1995 | Discrete Math1995，137，： | 1 |
| 6 | Substrate complexes of hepatitis C virus RNA polymerase(HC-J4):structural evidence for nucleotide import and de-novo initiation显示文摘 | O'Farrell D Trowbridge R Rowlands D J(a)ger J | | 0，，04： | 1 |
| 7 | Bortezomib for the treatment of mantle cell lymphoma 显示文摘 | Kane RC Dagher R Farrell A I | 2007 | Clin Cancer Res2007，13，181： | 1 |
| 8 | Delayed leaf senescence in ethylene-deficient ACC-oxidase antisense tomato plants:molecular and physiological analysis显示文摘 | JOHN I DRAKE R FARRELL A | 1995 | The Plant Journal1995，，7： | 1 |
| 9 | Estrogenrelated re- ceptor 1 actively antagonizes estrogen receptor regulated transcription in MCF-7 mammary cells 显示文摘 | KRAUS R J ARIAZI E A FARRELL M L | 2002 | J Biol Chem2002，277，24： | 1 |
| 10 | Enhancing nearinfrared avalanche photodiode performance by femtosecond laser microstructuring 显示文摘 | Myers R A Farrell R Karger A M | 2006 | Appl Opt2006，45，： | 1 |
| 11 | A rapid in vitro assay for evaluation of metabollsm-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes 显示文摘 | TABATABAEI A R THIES R L FARRELL K | 1997 | Fundam Appl Toxicol1997，37，2： | 1 |
| 12 | Imparied transport of leptin across the blood-brain barrier inobesity显示文摘 | BANKS W A DIPALMA C R FARREL C L | 1999 | Peptides1999，20，： | 1 |
| 13 | Ethanol can contribute to energy and environmental goals显示文摘 | FARRELL A E PLEVIN R J TURNER B T | 2006 | Science2006，311，： | 1 |
| 14 | Quantizer effects on steady-state error specification of digital feedback control systems显示文摘 | MILLER R K MICHEL A N FARRELL J A | 1989 | IEEE Transactions on Automatic Control1989，34，6： | 1 |
| 15 | Phy显示文摘 | Stem E A Farrell R A | 1960 | Rev1960，120，： | 1 |
| 16 | Mesoporous bis- muth ferrite with amplified magnetoelectric coupling and elec- tric field-induced ferrimagnetism显示文摘 | Quickel T E Sehelhas L T Farrell R A | 2015 | Nature Communications2015，6，6562： | 1 |
| 17 | Approval summary for bortezomib for injection in the treatment of multiple myeloma 显示文摘 | Bross P F Kane R Farrell A T | 2004 | Clin Cancer Res2004，10，12： | 1 |
| 18 | Developmental decline in components of signaltransduction pathways regulating protein synthesis inpig muscle 显示文摘 | KIMBALL S R FARRELL P A NGUYEN H V etal | 2002 | American Journal of Physiology: En-docrinology and Metabolism2002，282，3： | 1 |
| 19 | Biological control of blue stain fungi on Populus tremuloides using selected Ophiostoma isolates显示文摘 | White-mcdougall W J Blanchette R A Farrell R L | 1998 | Holzforschung1998，52，3： | 1 |
| 20 | Silicon nanoparticles: applications in cell biology and medicine显示文摘 | O'FARRELL N HOULTON A HORROCKS B R | 2006 | Int J Nanomedicine2006，1，4： | 1 |
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