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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 4 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 5 | Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exoerine glands of adult mice显示文摘 | Jaszai J Janich P Farkas LM | 2007 | Histoehem Cell Biol2007，128，5： | 1 |
| 6 | Inclinations of the facial profile: art versus reality 显示文摘 | Farkas LG Sohm P Kolar JC | 1985 | Plast Reconstr Surg1985，75，4： | 1 |
| 7 | Norovirus and histo-blood group antigens:demonstration of a wide spectrum of strain speci-ficities and classification of two major binding groups among multiple binding patterns显示文摘 | Huang P Farkas T Zhong W | 2005 | J Virol2005，79，11： | 1 |
| 8 | Optimisation of a steel tower for a wind turbine structure 显示文摘 | Uys P E Farkas J Jarmai K | 2007 | Engineering Structures2007，，29： | 1 |
| 9 | The receptor for advanced glyeation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival 显示文摘 | Kang R Tang D Schapiro NE Livesey KM Farkas A Longhran P | 2010 | Cell Death Differ2010，17，4： | 1 |
| 10 | Predictive validity of end- points used in electrophysiological modelling of migraine in the tri- geminovascular system显示文摘 | Farkas B Kardos P Orosz S | 2015 | Brain Res2015，1625，： | 1 |
| 11 | Noroviruses bind to human ABO,Lewis,and secretor histo-blood group antigens:identification of 4 distinct strain-specific patterns显示文摘 | Huang P Farkas T Marionneau S | 2003 | J Infect Dis2003，188，1： | 1 |
| 12 | Self-organizing pedestrian movement 显示文摘 | Helbing D Molnar P Farkas I | 2001 | Environment and Planning B2001，28，： | 1 |
| 13 | Key odourants of pressure-cooked hen meat显示文摘 | Farkas P Sadecka J Kovac M | 1997 | Food Chemistry1997，60，4： | 1 |
| 14 | Genomic and phylogenetic analyses of an adenovirus isolated from a corn snake(Elapheguttata) imply a common origin with member of the proposed new genus Atadenovirus显示文摘 | Szilvia L Farkas M Benk P | 2002 | Journal of General Virology2002，83，： | 1 |
| 15 | Cerebral microvascular pathology in aging and Alzheimer's disease显示文摘 | Farkas E Luiten P G | 2001 | Prog Neurobiol2001，64，6： | 1 |
| 16 | A half-century of environmetat mineral formation on a pyrite-bearing waste dump in the mCttra mountains, hungary 显示文摘 | Izabella M Farkas Tam(xs G Weiszburg P6ter P | 2009 | The Canadian Mineralogist2009，47，： | 1 |
| 17 | Dislocation activity and nano-void formation near crack tips in nanocrystalline ni显示文摘 | FARKAS D VAN P S DERLET P M | 2005 | Acta Materialia2005，53，： | 1 |
| 18 | Stability properties of positive solutions to partial differential equations with delay 显示文摘 | FARKAS G SIMON P L | 2001 | Electronic Journal of Differential Equations2001，，： | 1 |
| 19 | Determination of acrylamide in sugar by capillary GLC with alkali flame-ionization detection显示文摘 | Tekel J Farkas P Kovác M | 1989 | Food Additives and Contaminants1989，6，3： | 1 |
| 20 | Norovirus and histo-bloodgroup antigens: demonstration of a wide spectrum of strain speci-tiple binding patterns 显示文摘 | Huang P Farkas T Zhong W | 2005 | J Virol2005，79，11： | 1 |
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