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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | PPA-SiO_2 catalyzed efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation under solvent-free conditions显示文摘硅石支持胶化的 polyphosphoric 酸(PPA-SiO2 ) 被发现是为在高度负担得起相应 polyhydroquinoline 衍生物的芳基醛, dimedone,乙醇 acetoacetate 和铵醋酸盐的四部件的 Hantzsch 冷凝作用反应产出的一个壶的有效催化剂。现在的途径的主要优点是短反应时间,干净反应侧面,简单试验性并且 workup 过程。 | Amir Khojastehnezhad Farid Moeinpour Abolghasem Davoodnia | 2011 | Chinese Chemical Letters2011，22，7： | 12 |
| 3 | Rheological aspects of dysphagia-oriented food products:A mini review显示文摘Dysphagia is a symptom,commonly found in healthcare residents and the elderly,may lead to undernutrition and negative effects on quality of life.Providing special food products that cannot only be swallowed by patients but also meet nutritional requirements is a challenge for food rheologists and healthcare staff.The purpose of this paper was to review the literature on rheological aspects of dysphagia-oriented products.Also,some suggestions were proposed for better exploitation of rheological data in the field of dysphagia-rheology.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Azizollaah Zargaraan Reza Rastmanesh Ghasem Fadavi Farid Zayeri Mohammad Amin Mohammadifar | 2013 | Food Science and Human Wellness2013，2，3： | 7 |
| 4 | Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma:a systematic review显示文摘BACKGROUND: Various scoring systems based on assessment of the systemic inflammatory response help assessing the prognosis of patients with pancreatic ductal adenocarcinoma.In the present systematic review we evaluated the validity of four pre-intervention scoring systems: Glasgow prognostic score(GPS) and its modified version(mGPS), platelet lymphocyte ratio(PLR), neutrophil lymphocyte ratio(NLR), and prognostic nutrition index(PNI).DATA SOURCES: MOOSE guidelines were followed and EMBASE and MEDLINE databases were searched for all published studies until September 2013 using comprehensive text word and MeSH terms. All identified studies were analyzed, and relevant studies were included in the systematic review.RESULTS: Six studies were identified for GPS/mGPS with3 reporting statistical significance for GPS/mGPS on both univariate analysis(UVA) and multivariate analysis(MVA).Two studies suggested prognostic significance on UVA but not MVA, and in the final study UVA failed to show significance.Eleven studies evaluated the prognostic value of NLR. Six of them reported prognostic significance for NLR on UVA that persisted at MVA in 4 studies, and in the remaining 2 studies NLR was the only significant factor on UVA. In the remaining5 studies, all in patients undergoing resection, there was no significance on UVA. Seven studies evaluated PLR, with only one study demonstrated its prognostic significance on both UVAand MVA, the rest did not show the significance on UVA. Of the two studies identified for PNI, one demonstrated a statistically significant difference in survival on both UVA and MVA, and the other reported no significance for PNI on UVA.CONCLUSIONS: Both GPS/mGPS and NLR may be useful but further better-designed studies are required to confirm their value. PLR might be little useful, and there are at present inadequate data to assess the prognostic value of PNI. At present, no scoring system is reliable enough to be accepted into routine use for the prognosis of patients with pancreatic ductal adenocarcinoma. | Jawad Ahmad Nathan Grimes Shahid Farid Gareth Morris-Stiff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 7 |
| 5 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 6 | 铜及其配合物在生物体系中的作用显示文摘自人类有历史记载以来,铜及其配合物即用作药物。铜是人体必需的金属元素。人体的正常代谢过程需要它们,但无法体内合成,因此,需要每天从饮食摄取和吸收。生物药学家和研究者以极大的努力彻底地了解铜及其配合物在生物体系中的作用,希望获得更多地信息以利于人类疾病的预防和治疗。本综述评述了铜在组织中的分配和代谢、铜依赖酶、在病态时铜的非正常代谢、铜配合物的药疗活性和抑制氧自由基的产生。 | Khan* M. Farid Ismail, Norhayati Yusof, Ahmad Pauzi M. Khan*, Gul Majid(School of Pharmaceutical Sciences, University Sains Malaysia, 11800 Pulau Pinang, Malaysia) | 1998 | 无机化学学报1998，14，1： | 7 |
| 7 | Adsorptive removal of iron and manganese ions from aqueous solutions with microporous chitosan/polyethylene glycol blend membrane显示文摘Microporous chitosan(CS) membranes were directly prepared by extraction of poly(ethylene glycol)(PEG) from CS/PEG blend membrane and were examined for iron and manganese ions removal from aqueous solutions.The different variables affecting the adsorption capacity of the membranes such as contact time,pH of the sorption medium,and initial metal ion concentration in the feed solution were investigated on a batch adsorption basis.The affinity of CS/PEG blend membrane to adsorb Fe(II) ions is higher than that of Mn(II) ions,with adsorption equilibrium achieved after 60 min for Fe(II) and Mn(II) ions.By increasing CS/PEG ratio in the blend membrane the adsorption capacity of metal ions increased.Among all parameters,pH has the most significant effect on the adsorption capacity,particularly in the range of 2.9-5.9.The increase in CS/PEG ratio was found to enhance the adsorption capacity of the membranes.The effects of initial concentration of metal ions on the extent of metal ions removal were investigated in detail.The experimental data were better fitted to Freundlich equation than Langmuir.In addition,it was found that the iron and manganese ions adsorbed on the membranes can be effectively desorbed in 0.1 mol/L HCl solution(up to 98% desorption efficiency) and the blend membranes can be reused almost without loss of the adsorption capacity for iron and manganese ions. | Neama A.Reiad Omar E.Abdel Salam Ehab F.Abadir Farid A.Harraz | 2012 | Journal of Environmental Sciences2012，24，8： | 7 |
| 8 | 市内变电站接地系统的设计和分析显示文摘为了更好地进行市内变电站的设计和分析,介绍了市内变电站接地系统的基本设计流程,重点讨论了进行市内接地系统设计分析与常规郊区接地系统相比需考虑和出现的新问题。分析结果表明,与常规的接地系统相比,在进行市内接地系统设计时除了要考虑各种常规因素外,还需考虑可能的多块土壤结构、各电压等级电缆在故障电流分布计算中的影响,以及考虑电站入地电流对周边构筑物以及民用设施的安全影响等方面,否则会对电站评估安全计算结果带来显著的误差,遗漏周边安全性评估等,造成安全隐患。 | 周亮 徐骏 刘垚 付龙海 李业旭 Farid Paul Dawalibi | 2016 | 电网与清洁能源2016，32，12： | 6 |
| 9 | Recent insights into androgen action on the anatomical and physiological substrate of penile erection显示文摘可勃起的反应被雄激素集中地并且外围地调整。进雄激素的行动的机制的原来的卓见是雄激素特别地在性欲上施加效果并且响应性爱刺激的勃起是相对雄激素无关的。在男人的性函数在睾丸激素的引用值的低结束要求了雄激素层次,这被显示出。那么看起来睾丸激素不是为有可勃起的困难的男人的有用处理,特别地跟随磷酸二酯酶类型的来临 5 (PDE5 ) 禁止者。然而,与 PDE5 禁止者对待的约 50% 那些中止他们的处理。很多最近的开发在使人变老在可勃起的机能障碍(编辑) 的睾丸激素处理上打开新灯。(1 ) 最近的卓见是与更年轻的男人相对照,老男人可能为正常性工作要求睾丸激素的高水平。(2 ) 几研究显示了 PDE5 禁止者不总是是足够的在男人恢复可勃起的力量,并且那睾丸激素更加改进 therapeutical 反应到 PDE5 禁止者。(3 ) 正在种睾丸激素有的卓见阴茎的纸巾上的深刻效果在勃起和那睾丸激素缺乏的机制包含了损害可勃起的能力的解剖、生理的底层,在雄激素代替之上可逆。PDE5 的合成起来由雄激素调整了,并且进阴茎的动脉的流入被给雄激素改进。上面邀请把睾丸激素给与编辑使人变老的优点的复试 PDE5 禁止者的有益的效果可以最佳地仅仅在 eugonadal 环境被表示。 | Louis J.G.Gooren Farid Saad | 2006 | Asian Journal of Andrology2006，8，1： | 6 |
| 10 | Effect of acupotomy versus electroacupuncture on ethology and morphology in a rabbit model of knee osteoarthritis显示文摘OBJECTIVE: To evaluate the treatment effect of acupotomy(Apo) in a rabbit model of knee osteoarthritis(KOA), compare the results of Apo versus electroacupuncture(E-Apu) on ethology, morphology, and structure of the articular cartilage surface in a rabbit model of KOA, and analyze the differences in the treatment effects of Apo versus E-Apu.METHODS: Twenty-eight male New Zealand white rabbits were randomized into four groups: normal control, blank model, Apo, and E-Apu(n = 7 in each group). Except for the normal control group, the left hindlegs of all rabbits were fixed in an extended position for 5 weeks to establish the KOA model.The passive range of motion(PROM) and Lequesne index were measured before and after the establishment of the KOA model to assess the ethology in all groups. Safranin O-fast green staining and the Mankin score were used to assess the morphological cartilaginous changes to compare the effect of Apo versus E-Apu on the degeneration of articular cartilage, and to identify which therapy was superior in treating KOA.RESULTS: Compared with before the establishment of the KOA model, the Lequesne index of the KOA model rabbits was significantly increased(P <0.01), while the PROM was significantly decreased(P < 0.01). The articular cartilaginous tissue in the three model groups exhibited pathological variations in the form of laminar derangement of cartilage cells, and so the Mankin score was significantly increased compared with the control group(P <0.01). At 1 week after the final treatment session,compared with the blank model group, both the Apo and E-Apu groups showed a significant decrease in the Lequesne index(P < 0.01), and attenuation in the degree of morphologic pathological changes(P < 0.05); The Apo improved the PROM significantly compared with the blank model group(P < 0.05), while the E-Apu had no effect(P > 0.05).Furthermore, compared with the E-Apu group, the Apo group had a significantly lower Lequesne index(P < 0.05), and a significantly greater PROM(P <0.05).CONCLUSION: In a rabbit model of KOA, both Apo and E-Apu reduce disorders of ethology and morphology, and improve the condition of the articular cartilage. The results suggest that Apo is more effective than E-Apu in improving the PROM and alleviating symptoms resulting from cartilage damage in a rabbit model of KOA. | Zhang Wei Gao Yang Guo Changqing Ibrahim Zeyad Ali Khattab Farid Mokhtari | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 6 |
| 11 | TiC-Maraging stainless steel composite:microstructure, mechanical and wear properties显示文摘Particulate TiC reinforced 17-4PH and 465 maraging stainless steel matrix composites were processed by con- ventional powder metallurgy (P/M). TiC-maraging stainless steel composites with theoretical density >97% were produced using conventional P/M. The microstructure, and mechanical and wear properties of the composites were evaluated. The microstructure of the composites consisted of (core-rim structure) spherical and semi-spherical TiC particles depending on the wettability of the matrix with TiC particles. In TiC-maraging stainless steel composites, 465 stainless steel binder phase showed good wettability with TiC particles. Some microcracks appeared in the composites, indicating the presence of ten- sile stresses in the composites produced during sintering. The typical properties, hardness, and bend strength were reported for the composites. After heat treatment and aging, an increase in hardness was observed. The increase in hardness was at- tributed to the aging reaction in maraging stainless steel. The specific wear behavior of the composites strongly depends on the content of TiC particles and their interparticle spacing, and on the heat treatment of the maraging stainless steel. | Akhtar Farid Khadijah Ali Shah Syed Javid Askari | 2006 | Rare Metals2006，25，6： | 6 |
| 12 | Endo-β-1,4-glucanases impact plant cell wall development by influencing cellulose crystallization显示文摘Cell walls are vital to the normal growth and development of plants as they protect the protoplast and provide rigidity to the stem. Here, two poplar and Arabidopsis orthologous endoglucanases, which have been proposed to play a role in secondary cell wall development, were examined. The class B endoglucanases, Pt GH9B5 and At GH9B5, are secreted enzymes that have a predicted glycosylphosphatidylinositol anchor, while the class C endoglucanases, Pt GH9C2 and At GH9C2, are also predicted to be secreted but instead contain a carbohydrate-binding module.The poplar endoglucanases were expressed in Arabidopsis using both a 35 S promoter and the Arabidopsis secondary cell wall-specific Ces A8 promoter. Additionally, Arabidopsis t-DNA insertion lines and an RNAiconstruct was created to downregulate At GH9C2 in Arabidopsis. All of the plant lines were examined for changes in cell morphology and patterning, growth and development, cell wall crystallinity, micro fibril angle, and proportion of cell wall carbohydrates. Misregulation of Pt GH9B5/At GH9B5 resulted in changes in xylose content, while misregulation of Pt GH9C2/At GH9C2 resulted in changes in crystallinity, which was inversely correlated with changes in plant height and rosette diameter. Together, these results suggest that these endoglucanases affect secondary cell wall development by contributing to the cell wall crystallization process. | Magdalena Glass Sarah Barkwill Faride Unda Shawn D.Mansfield | 2015 | Journal of Integrative Plant Biology2015，57，4： | 6 |
| 13 | 阿司匹林及氯吡格雷双抗与阿司匹林单药治疗急性轻度缺血性卒中及高危短暂性脑缺血发作的比较:系统综述及meta分析显示文摘目的为了评估对于急性轻度缺血性卒中及短暂性脑缺血发作(TIA)患者应用联合阿司匹林及氯吡格雷双抗治疗,相较于单用阿司匹林,预防血栓再发及出血事件的有效性及安全性。研究设计对随机、安慰剂对照研究进行系统综述及meta分析。 | Qiukui Hao Malavika Tampi Martin O' Donnell Farid Foroutan Reed AC Siemieniuk Gordon Guyatt 李洁(译) 毛晨晖(校) | 2019 | 英国医学杂志中文版2019，22，5： | 5 |
| 14 | Visual performance of four types of diffractive multifocal intraocular lenses and a review of articles显示文摘AIM: To compare the clinical outcomes of a variety of multifocal intraocular lenses(MIOLs) in patients diagnosed with presbyopia or cataracts. METHODS: This clinical trial study included 141 patients(282 eyes) with different MIOLs implantation. The Symfony(60 eyes), the Re STOR(100 eyes), the AT LISAtri(60 eyes), and the Pan Optix(62 eyes) intraocular lenses were evaluated in this prospective interventional study. The near, intermediate, and distant visual acuities, contrast sensitivity, and defocus curve were measured as valid criteria. To statistically analyze the results, we used the Statistical Package for Social Science software, the non-parametric Wilcoxon signed-rank t, the one-way analysis of variance and the Tukey’s post-hoc test in our analysis. Moreover, we conducted a detailed literature search on the Pub Med database in English about MIOLs, in total 59 studies were included in this review article.RESULTS: The four approaches did not show any significant difference in the best-corrected distance visual acuity(P>0.05). The defocus curves at the contrast of 100% showed that trifocal IOLs had better intermediate performance than the bifocal IOL(P<0.05). There were no statistically significant differences between AT LISAtri and Pan Optix lenses for visual acuity at all distances. The eyes with Pan Optix, Symfony, and AT LISAtri IOL showed better contrast sensitivity than those Re STOR at spatial frequencies of 1, 3, and 6 cpd in photopic and mesopic conditions(P<0.001). CONCLUSION: All four groups of the multifocal lenses were satisfying in terms of distance and near vision. Also, the group of trifocal lenses led to satisfactory outcomes in intermediate vision, without degradation in quality of vision. | Farideh Doroodgar Feizollah Niazi Azad Sanginabadi Farid Karimian Sana Niazi Cyrus Alinia Mohammad Ali Javadi | 2021 | International Journal of Ophthalmology(English edition)2021，14，3： | 5 |
| 15 | Development of Si_3N_4/Al composite by pressureless melt infiltration显示文摘Pressureless infiltration process to synthesize Si3N4/Al composite was investigated. Al-2%Mg alloy was infiltrated into Si3N4 and Si3N4 containing 10% Al2O3 preforms in the atmosphere of nitrogen. It is possible to infiltrate Al-2%Mg alloy in Si3N4 and Si3N4 containing 10% Al2O3 preforms. The growth of the dense composite of useful thickness was facilitated by the presence of magnesium powder at the interface and by flowing nitrogen. During infiltration Si3N4 reacted with aluminium to form Si and AlN, the growth of composite was found to proceed in two ways, depending on the Al2O3 content in the initial preform. Firstly, preform without Al2O3 content gives rise to AlN, Al3.27Si0.47 and Al type phases after infiltration. Secondly, perform with 10% Al2O3 content gives rise to AlN-Al2O3 solid solution phase (AlON), MgAl2O4, Al and Si type phases. AlON phase was only present in composite, containing 10% Al2O3 in the Si3N4 preforms before infiltration. | Akhtar Farid | 2006 | 中国有色金属学会会刊:英文版2006，16，3： | 5 |
| 16 | Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury:a proof of principle study显示文摘Despite emerging contemporary biotechnological methods such as gene-and stem cell-based therapy,there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury.Our previous studies have demonstrated that transplantation of genetically engineered human umbilical cord blood mononuclear cells producing three recombinant therapeutic molecules,including vascular endothelial growth factor(VEGF),glial cell-line derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)can improve morpho-functional recovery of injured spinal cord in rats and mini-pigs.To investigate the efficacy of human umbilical cord blood mononuclear cells-mediated triple-gene therapy combined with epidural electrical stimulation in the treatment of spinal cord injury,in this study,rats with moderate spinal cord contusion injury were intrathecally infused with human umbilical cord blood mononuclear cells expressing recombinant genes VEGF165,GDNF,NCAM1 at 4 hours after spinal cord injury.Three days after injury,epidural stimulations were given simultaneously above the lesion site at C5(to stimulate the cervical network related to forelimb functions)and below the lesion site at L2(to activate the central pattern generators)every other day for 4 weeks.Rats subjected to the combined treatment showed a limited functional improvement of the knee joint,high preservation of muscle fiber area in tibialis anterior muscle and increased H/M ratio in gastrocnemius muscle 30 days after spinal cord injury.However,beneficial cellular outcomes such as reduced apoptosis and increased sparing of the gray and white matters,and enhanced expression of heat shock and synaptic proteins were found in rats with spinal cord injury subjected to the combined epidural electrical stimulation with gene therapy.This study presents the first proof of principle study of combination of the multisite epidural electrical stimulation with ex vivo triple gene therapy(VEGF,GDNF and NCAM)for treatment of spinal cord injury in rat models.The animal protocols were approved by the Kazan State Medical University Animal Care and Use Committee(approval No.2.20.02.18)on February 20,2018. | Filip Olegovich Fadeev Farid Vagizovich Bashirov Vahe Arshaluysovich Markosyan Andrey Alexandrovich Izmailov Tatyana Vyacheslavovna Povysheva Mikhail Evgenyevich Sokolov Maxim Sergeevich Kuznetsov Anton Alexandrovich Eremeev Ilnur Ildusovich Salafutdinov Albert Anatolyevich Rizvanov Hyun Joon Lee Rustem Robertovich Islamov | 2021 | Neural Regeneration Research2021，16，3： | 4 |
| 17 | Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats显示文摘瞄准:估计他我在勃起组织 ofsildenafil 的 oxygenase-1 (HO-1 ) 活动对待柠檬酸盐的老鼠。方法:192 只 Sprague-Dawley 雄的老鼠,划分了成四个相等的组,被调查。组织 1,控制组,收到的常规动物食物;由胃内试管组织 2 收到的 sildenafil 柠檬酸盐;组 3 收到的 sildenafiland 惊讶禁止者(锌原卟啉, ZnPP ) ;并且组 4 收到了 sildenafil 和氮的 oxidesynthase (NOS ) 禁止者 L-nitroarginine 甲基酉旨(L 名字) 。从每个组的 12 只老鼠在 0.5 h, 1 h, 2 h 和药管理的 3 h 以后被打死。然后,在勃起组织的 HO-1 活动, cGMP 层次和 NOSenzymatic 活动被估计。结果:在勃起组织, HO-1activity, NOS 酶的活动和 cGMP,集中在整个实验与另外的组相比增加了显著地对待 insildenafil 的老鼠。收到任何一个 HOor NOS 禁止者的老鼠在这些参数显示出重要减少。酶的活动表明了的 HO-1 勃起组织活动和 NOS 与 cGMP 层次的积极重要关联(r =0.646, r = 0.612 分别地;P <
0.001 ) 。结论:在勃起组织的 PDE_5 禁止者 sildenafilcitrate 的行动部分通过在 HO-1 和 NOS 活动之间的相互依赖的关系被调停。 | M. Talaat Abdel Aziz M. Farid Al-Asmar Taymour Mostafa Hazem Atta Laila Rashed Dina Sabry Shedeed Ashour Ahmed T. Abdel Aziz | 2007 | Asian Journal of Andrology2007，9，3： | 4 |
| 18 | Treatment of Benzene,Toluene and Xylene Contaminated Air in a Bioactive Foam Emulsion Reactor显示文摘A novel bioactive foam emulsion bioreactor for benzene,toluene and xylene(BTX)contaminated air streams treatment has been developed.The gas-liquid interfacial area by biocompatible foam and driving force for mass transfer by a water immiscible organic phase were increased in this reactor.The effect of several parameters such as gas residence time,oxygen content,and organic phase concentration on bioreactor performance was studied. Experimental results showed an average elimination capacity(EC)of 220 g·m3·h -1with removal efficiency(RE) of 89.59%for BTX inlet concentration of 1 g·m3at 15 s gas residence time in the bioreactor.The statistical developed model predicted that the maximum elimination capacity of the reactor for BTX could be reached to 423.45 g·m3·h -1.Continues operation of the bioreactor with high EC and RE was demonstrated by optimizing the operational parameters of the bioreactor.Overall the results suggest that the bioreactor developed can be very effective systems to treat BTX vapors. | Farshid Ghorbani Shahna Faride Golbabaei Javad Hamedi Hossein Mahjub Hossein Reza Darabi Seyed Jamaladdin Shahtaheri | 2010 | Chinese Journal of Chemical Engineering2010，18，1： | 4 |
| 19 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 20 | A review on energy conservation in building applications with thermal storage by latent heat using phase change materials显示文摘 | Amar M. Khudhair Mohammed M. Farid | 2003 | Energy Conversion and Management2003，，2： | 3 |
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