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| 1 | Cost-effectiveness analysis of population-based screening of hepatocellular carcinoma: Comparing ultrasonography with two-stage screening显示文摘AIM: To assess the cost-effectiveness of two populationbased hepatocellular carcinoma(HCC) screening programs, two-stage biomarker-ultrasound method and mass screening using abdominal ultrasonography(AUS).METHODS: In this study, we applied a Markov decision model with a societal perspective and a lifetime horizon for the general population-based cohorts in an area with high HCC incidence, such as Taiwan. The accuracy of biomarkers and ultrasonography was estimated from published meta-analyses. The costs of surveillance, diagnosis, and treatment were based on a combination of published literature, Medicare payments, and medical expenditure at the National Taiwan University Hospital. The main outcome measure was cost per lifeyear gained with a 3% annual discount rate. RESULTS: The results show that the mass screening using AUS was associated with an incremental costeffectiveness ratio of USD39825 per life-year gained, whereas two-stage screening was associated with an incremental cost-effectiveness ratio of USD49733 per life-year gained, as compared with no screening. Screening programs with an initial screening age of 50 years old and biennial screening interval were the most cost-effective. These findings were sensitive to the costs of screening tools and the specificity of biomarker screening.CONCLUSION: Mass screening using AUS is more cost effective than two-stage biomarker-ultrasound screening. The most optimal strategy is an initial screening age at 50 years old with a 2-year inter-screening interval. | Ming-Jeng Kuo Hsiu-Hsi Chen Chi-Ling Chen Jean Ching-Yuan Fann Sam Li-Sheng Chen Sherry Yueh-Hsia Chiu Yu-Min Lin Chao-Sheng Liao Hung-Chuen Chang Yueh-Shih Lin Amy Ming-Fang Yen | 2016 | World Journal of Gastroenterology2016，22，12： | 12 |
| 2 | Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma显示文摘AIM To explore factors associated with persistent hepatitis B virus(HBV) infection in a cohort of hepatocellular carcinoma(HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen(HBsA g)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structuredquestionnaire. Demographics, relationship to index case, HBs Ag status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation(P = 0.0076), index generation(P = 0.0044), mothers positive for HBs Ag(P = 0.0007), and HBs Ag-positive index cases(P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBs Ag-positive relatives. Parent generation(P = 0.0359) and sex(P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBs Ag-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46(58.7%) families. Male offspring of HBsA gpositive mothers(P = 0.024) and older siblings were associated with high viral load.CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations. | Ai-Ru Hsieh Cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai | 2017 | World Journal of Gastroenterology2017，23，5： | 2 |
| 3 | Heat and fluid flow inside rotating channels显示文摘 | Yang W.J Fann S Kim J.H | | 0，，08： | 1 |
| 4 | Protection against lethal enterovirus 71 in- fection in newborn mice by passive immunization with subunit VP1 vacci- nesand inactivated virus 显示文摘 | Wu CN Lin YC Fann C | 2002 | Vaccine2002，20，56： | 1 |
| 5 | Validation of postural radiographs as a way to measure change in pelvic obliquity 显示文摘 | Fann AV | 2003 | Arch Phys Med Rehabil2003，84，1： | 1 |
| 6 | Aortic dissection显示文摘 | Fann JI Miller DC | 1995 | Ann Vasc Surg1995，8，： | 1 |
| 7 | Protection against lethal en- terovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus 显示文摘 | Wu CN Lin YC Fann C | | Vaccine 200l0，20，56： | 1 |
| 8 | Aortic dissection显示文摘 | James I. Fann MD D. Craig Miller MD | 1995 | Annals of Vascular Surgery1995，，3： | 1 |
| 9 | Evolving strategies for the treatment of valvular heart disease: Preclinical and clinical pathways for percutaneous aortic valve replacement显示文摘 | FANN J I CHRONOS N ROWE S J | 2008 | Catheter Cardiovasc Interv2008，71，： | 1 |
| 10 | Protection against lethal en- terovirus in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus 显示文摘 | WU C N LIN Y C FANN C | 2001 | Vaccine2001，20，56： | 1 |
| 11 | Charge storage behavior of nanowire transistors functionalized with bis(terpyridine)-Fe(II) mole- cules 显示文摘 | LI C FANN W STRAUS D A | 2004 | JAm Chem Soe2004，126，： | 1 |
| 12 | Intrahepatic cholangiocarcinoma and hepatitis:case study and literature review显示文摘 | Luh F Kuei A Fann P | 2009 | Anticancer Res2009，29，8： | 1 |
| 13 | Endovascular stent- grafting after arch aneurysm repair using the 'elephant trunk' 显示文摘 | Fann JI Dake MD Semba CP | 1995 | Ann Thorac Surg1995，60，4： | 1 |
| 14 | GPS-less low cost outdoor localization for very small devices显示文摘 | Bulusu N Heidemann J Fann D | 2010 | IEEE personal Communications2010，7，5： | 1 |
| 15 | Endovascular treatment of descending thoracic aortic aneurysms and dissections显示文摘 | Fann JI Miller DC | 1999 | Surg Clin North Am1999，79，3： | 1 |
| 16 | urgical management of aortic dissection during a 30- year period 显示文摘 | Smith JA Miller DC | 1995 | Circulation1995，，： | 1 |
| 17 | Environ- mental scanning practices in small business 显示文摘 | SMELTZER L R FANN G L NIKOLAISEN V N | 1988 | Journal of Small Business Management1988，26，3： | 1 |
| 18 | Influence of Hy- drolysis Degree on the Functional Properties of Salmon Byproduct Hydrolysates显示文摘 | GBOGOUR G A LINDER M FANN I J | 2004 | Journal of Food Science2004，69，： | 1 |
| 19 | Protection against lethal enterovirus 71 infection in newborn mice by passive immu- nization with subunit VP1 vaccines and inactivated virus 显示文摘 | Wu CN Lin YC Fann C | 2001 | Vaccine2001，20，56： | 1 |
| 20 | Intravenous immunoglobulin sup- presses NLRP1 and NLRP3 inflammasome-mediated neuronal death ischemic stroke显示文摘 | Fann DY Lee SY Manzanero S | 2013 | Cell Death Dis2013，4，： | 1 |
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