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| 1 | A special numerical method for fluid-structure interaction problems subjected to explosion and impact loading显示文摘A three-dimensional(3D) embedded Eulerian-Lagrangian method is proposed to simulate the 3D fluid-structure interaction(FSI) problems subjected to explosion and impact loading. This method achieves a high-quality calculation of fluid and structure deformation by adding Lagrangian particles to Eulerian grids. The overall computational domain is solved by the Eulerian method, and the Lagrangian particles with specified volume and influence domains are used to track structural deformations. The bidirectional mapping of physical quantities is achieved using the weighted average of the influence domain, which are based on the topological relationship between Eulerian grids and Lagrangian particles. Then, the data dependence solution and parallel algorithm realization are presented for the large-scale numerical calculations of explosion and impact problems. Additionally, the corresponding parallel program is developed based on the message passing interface(MPI) standard, and the parallel efficiency of parallel hydrocode are tested. The numerical results of typical explosion and impact problems are compared with corresponding experimental data to verify the effectiveness of the method. These comparisons show that the embedded EulerianLagrangian method successfully combine the advantages of both the Eulerian and Lagrangian methods to efficiently calculate the processes of large deformation and dynamic damage to the materials. The results presented in this work provide a useful reference point for further research on explosion and impact problems. | NING JianGuo MENG FanLin MA TianBao XU XiangZhao | 2020 | Science China(Technological Sciences)2020，63，7： | 4 |
| 2 | Optimal dynamic pricing for smart grid having mixed customers with and without smart meters显示文摘This paper investigates an optimal day-ahead dynamic pricing problem in an electricity market with one electricity retailer and multiple customers. The main objective of this paper is to support the retailer to make the best day-ahead dynamic pricing decision, which maximizes its profit under the realistic assumption that mixed types of customers coexist in the electricity market where some customers have installed smart meters with the embedded home energy management system in their home whereas other customers have not installed smart meters. To this end, we propose a hybrid demand modelling framework which firstly uses an optimal energy management algorithm with bill minimization to model the behavior of customers with smart meters and secondly use a data-driven demand modelling method to model the behavior of customers without smart meters. Such a hybrid demand model can not only schedule usages of home appliances to the interests of customers with smart meters but also be used to understand electricity usage behaviors of customers without smart meters. Based on the established hybrid demand model for all customers, a profit maximization algorithm is developed to achieve optimal prices for the retailer under relevant market constraints. Under the condition of no growth of the revenue(i.e. no increase of total bill from all customers), simulation results indicate our optimization algorithm can improve the profit for around 5% on average. | Qian MA Fanlin MENG Xiao-Jun ZENG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 3 |
| 3 | Experimental and theoretical investigation of the failure behavior of a reinforced concrete target under high-energy penetration显示文摘The dynamic mechanical properties of concrete and reinforced concrete targets subjected to high-speed projectile impact loading have a significant influence on the impact resistance of protective structures.In this study,high-speed projectile penetration and perforation of concrete and reinforced concrete structures was carried out to determine the high-energy impact loading.The failure behaviors of projectile penetration and perforation of the concrete and reinforced concrete targets were investigated,and the destruction characteristics of the targets were measured.An analytical model was established using the principle of minimum potential energy.The results show that the theoretical predictions are consistent with the experimental data,indicating that the energy method is effective for predicting the dynamic mechanical properties of concrete and reinforced concrete targets under high-speed projectile penetration. | Fanlin Meng Tianbao Ma Xiangzhao Xu | 2020 | Acta Mechanica Sinica2020，36，1： | 2 |
| 4 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 5 | Gene expression programming algorithms for optimization of water distribution networks显示文摘 | Wang Huanhuan Liu Shuming Meng Fanlin | 2012 | Procedia Engineering2012，37，： | 1 |
| 6 | Research of brushless DC motor simu- lation system based on RBF-PID algorithm 显示文摘 | Fan Xu Meng Fanlin | 2009 | Second Interna- tional Symposium on Knowledge Acquisition and Modeling2009，2，： | 1 |
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