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| 1 | Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Most recently,a new SARS-CoV-2 variant of concern(VOC)Z Omicron(B.1.1.529),was first reported to the World Health Organization(WHO)from South Africa and then quickly spread to many countries,1,2 posing a serious threat to current vaccine prevention and antibody therapeutic strategies.Several studies have reported that the Omicron variant successfully escapes from neutralizing antibodies elicited by COVID-19 vaccines or from COVID-19 convalescent patients. | Shuai Xia Jasper Fuk-Woo Chan Lijue Wang Fanke Jiao Kenn Ka-Heng Chik Hin Chu Qiaoshuai Lan Wei Xu Qian Wang Chao Wang Kwok-Yu ng Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，4： | 2 |
| 2 | Data-Driven Deep Learning for OTFS Detection显示文摘Recently,orthogonal time frequency space(OTFS)was presented to alleviate severe Doppler effects in high mobility scenarios.Most of the current OTFS detection schemes rely on perfect channel state information(CSI).However,in real-life systems,the parameters of channels will constantly change,which are often difficult to capture and describe.In this paper,we summarize the existing research on OTFS detection based on data-driven deep learning(DL)and propose three new network structures.The presented three networks include a residual network(ResNet),a dense network(DenseNet),and a residual dense network(RDN)for OTFS detection.The detection schemes based on data-driven paradigms do not require a model that is easy to handle mathematically.Meanwhile,compared with the existing fully connected-deep neural network(FC-DNN)and standard convolutional neural network(CNN),these three new networks can alleviate the problems of gradient explosion and gradient disappearance.Through simulation,it is proved that RDN has the best performance among the three proposed schemes due to the combination of shallow and deep features.RDN can solve the issue of performance loss caused by the traditional network not fully utilizing all the hierarchical information. | Yi Gong Qingyu Li Fanke Meng Xinru Li Zhan Xu | 2023 | China Communications2023，20，1： | 2 |
| 3 | Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation显示文摘The COVID-19 pandemic poses a global threat to public health and economy.The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines.In this study,we identified that EK1 and cholesterol-coupled derivative of EK1,EK1C4,as pan-CoV fusion inhibitors,exhibit potent antiviral activity against SARS-CoV-2 infection in both lung-and intestine-derived cell lines(Calu-3 and Caco2,respectively).They are also effective against infection of pseudotyped SARS-CoV-2 variants B.1.1.7(Alpha)and B.l.1.248(Gamma)as well as those with mutations in S protein,including N417T,E484K,N501Y,and D614G,which are common in South African and Brazilian variants.Crystal structure revealed that EK1 targets the HR1 domain in the SARS-CoV-2 S protein to block virus-cell fusion and provide mechanistic insights into its broad and effective antiviral activity.Nasal administration of EK1 peptides to hACE2 transgenic mice significantly reduced viral titers in lung and intestinal tissues.EK1 showed good safety profiles in various animal models,supporting further clinical development of EK1-based pan-CoV fusion inhibitors against SARS-CoV-2 and its variants. | Shuai Xia Qiaoshuai Lan Yun Zhu Chao Wang Wei Xu Yutang Li Lijue Wang Fanke Jiao Jie Zhou Chen Hua Qian Wang Xia Cai Yang Wu Jie Gao Huan Liu Ge Sun Jan Munch Frank Kirchhoff Zhenghong Yuan Youhua Xie Fei Sun Shibo Jiang Lu Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 4 | Large induction of the chemotactic cytokine RANTES experssion显示文摘 | Fank S Kanpfer H Wetzler C | 2000 | Biochem J2000，274，3： | 1 |
| 5 | Self-assmbled Monolayers in Electroanalytical Chemistry : Application of ω-Mercapto Carboxylic Acid Monolayers for the Electrochmical Detection of Dopamine in the Presence of a High Concentration of Ascorbic Acid 显示文摘 | Fank M | 1993 | Analytical Chemistry1993，65，： | 1 |
| 6 | Active filter systen implementation显示文摘 | BHATTACHARYA S FANK T M DIVAN D M B | 1998 | Industry Applications Magazine IEEE1998，4，5： | 1 |
| 7 | Development of meth- ods to detect 'Norwalk like viruses' (NLVs) and hepatitis A virus in delicatessen foods: Application to a food borne NLV outbreak显示文摘 | Schwab K J Neill FH Fank hauser RL | 2000 | Applied and Environmental Microbiology2000，66，1： | 1 |
| 8 | 微波消解一电感耦合等离子体法测定食用油中微量Pb、AS、Cd、Cu等多种重金属元素显示文摘 | YANGXY(杨小嫒) FANK(范柯) CAIYJ(蔡羽嘉) | 2013 | 药物分析杂志2013，23，8： | 1 |
| 9 | Enhancement of solar hydrogen generation by synergistic interaction of La2Ti2O7 photocatalyst with plasmonic gold nanoparticles and reduced graphene oxide nanosheets 显示文摘 | FANKE M CUSHING S K LI Jiangtian et a1 | 2015 | Catal2015，5，3： | 1 |
| 10 | Stochastic resonance and the benefits of noise: From ice ages to crayfish and SQUIDs显示文摘 | Kurt W Fank M | 1995 | Nature1995，373，5： | 1 |
| 11 | Prebiotics stimulate calcium absorption:a review显示文摘 | Fank A | 2005 | Food Australia2005，57，12： | 1 |
| 12 | Internal Cardioversion of chronic atrial fibrillation during percutaneous mitral commissurotomy:insight into reversal of chronic stretch-induced atrial remodeling显示文摘 | Lee KL | 2002 | Cireulation2002，105，23： | 1 |
| 13 | The Development of a Money-handling Inventory显示文摘 | | 1994 | Personality and Individual Differences1994，，17： | 1 |
| 14 | The bioartifitial renal tubule assiset device to enhance CRRT in acute renal failurel显示文摘 | Humes HD Mackay SM Fanke AJ | 1997 | Am J Kidney Dis1997，30，5： | 1 |
| 15 | Systematic review and meta analysis of 12 years of endovascular abdominal aortic aneurysm repair显示文摘 | Fanks SC Sutton AJ | 2007 | Eur J Vasc Endovascular Surg2007，33，2： | 1 |
| 16 | Large induction of the Chemotactic cytokine RANTES experssion显示文摘 | Fank S Kanpfer H Wetzler C | 2000 | Biochem J2000，274，3： | 1 |
| 17 | An new minimum zone method for evaluating straightness errors显示文摘 | Huang ST Fank C Wu JH | 1993 | Precision Engineering1993，，3： | 1 |
| 18 | Corrosion resistance propelies of aluminum wires for uhrasonie bonding 显示文摘 | Fank N D | 1999 | InternationalJournalof Microcircuits and Paekaging1999，2，22： | 1 |
| 19 | Effect of mierostructure on the hysteresis performance of force transducers using AISI4340 steel spring material 显示文摘 | Sinan Fank Mehmet Demirkol | 2006 | Sensors and Actuators2006，126，： | 1 |
| 20 | Influence of heat treatment on hysteresis error of force transducers manufacture from 17-4PH stainless steel 显示文摘 | Bulent Agdemir Erdinc Kaluc Sinan Fank | 2006 | Measurement2006，39，10： | 1 |
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