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| 1 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 2 | A two-hit model for developmental defects in Gorlin syndrome显示文摘 | Levanat S Gorlin R J Fallet S | 1996 | Nat Genet1996，12，1： | 1 |
| 3 | Prospective screening for ALK: clinical features and outcome according to ALK status显示文摘 | Fallet V Cadranel J Doubre H | 2014 | Eur J Cancer2014，50，7： | 1 |
| 4 | Influence of physico-structural properties on the photocatalytic activity of sol-gel derived TiO2 thin films显示文摘 | M. Fallet S. Permpoon J. L. Deschanvres M. Langlet | 2006 | Journal of Materials Science2006，，10： | 1 |
| 5 | Cortical radial glial cells in human fetuses:depth-correlated transformation into astrocytes显示文摘 | deAzevedo L C Fallet C Moura-Neto V | 2003 | J Neurobiol2003，55，3： | 1 |
| 6 | A two-hit model for developmental defects in Gorlin syndrome 显示文摘 | Levanat S Gorlin RJ Fallet S | 1996 | Nat Genet1996，12，1： | 1 |
| 7 | 显示文摘 | Fallet M Mahdjoub H Gautier B | 2001 | J Non-Cryst Solids2001，，： | 1 |
| 8 | Coexisting rheumatoid arthritis and ankylosing spondylitis显示文摘 | Fallet GH Barnes CG Berry H | 1987 | J Rheumatol1987，14，6： | 1 |
| 9 | Improvement of left ventricular relaxation as assessed by tissue Doppler ima- ging in fluid - responsive critically ill septic patients 显示文摘 | Mahjoub Y Benoit - Fallet H Airapetian N | 2012 | Intensive Care Med2012，38，9： | 1 |
| 10 | Exaggerated impact of ATP-sensitive K+ channels on afferent arteriolar diameter in diabetes mellitus显示文摘 | Ikenaga H Bast JP Fallet RW Carmines PK | 2000 | J Am Soc Nephrol2000，11，7： | 1 |
| 11 | Coexisting rheumatoid arthritis and ankylosing spondylitis显示文摘 | Fallet GH Bares CG Berry H | 1987 | JRheumatol1987，14，： | 1 |
| 12 | Rheumatoid arthritisand anky- losing spondylitis occuring together显示文摘 | Fallet GH Mason M Berry H | 1976 | Br Med J1976，1，： | 1 |
| 13 | Blood vessel invasion is a major feature and a factor of poor prognosis in sarcomatoid carcinoma of the lung显示文摘 | Thibault Vieira Martine Antoine Anne-Marie Ruppert Vincent Fallet Michael Duruisseaux Etienne Giroux Leprieur Virginie Poulot Nathalie Rabbe Laurene Sclick Michele Beau-Faller Roger Lacave Armelle Lavole Jacques Cadranel Marie Wislez | 2014 | Lung Cancer2014，，： | 1 |
| 14 | Variability in fo- raminiferal and organic paleotemperature signatures in the Mozambique Channel (SW Indian Ocean)显示文摘 | Fallet U Ullgren J E Castaneda I | 2011 | Geochimica et Cosmochimica Acta2011，75，： | 1 |
| 15 | Secondary resistance to erlotinib: acquired T790M mutation and small- cell lung cancer transformation in the same patient显示文摘 | Fallet V Ruppert AM Poulot V | 2012 | J Thorac Oncol2012，7，6： | 1 |
| 16 | Exaggerated impact of ATP-sensitive K+ channels on afferent arteriolar diameter in diabetes mellitus显示文摘 | Ikenaga H Bast JP Fallet RW Carmines PK | 2000 | J Am Soc Nephrol2000，11，： | 1 |
| 17 | A twohit model for developmental defects in Gorlin syndrome显示文摘 | Levanat S Gorlin RJ Fallet S | 1996 | Nat Genet1996，12，： | 1 |
| 18 | Antidiuretic principle in tuber-culous lung tissue of a patient with pulmonarytuberculosis and hy-ponatremia 显示文摘 | Vorherr H Massry SG Fallet R | 1970 | Ann Intern Med1970，72，3： | 1 |
| 19 | Supratentorial parenchyma in the deve-loping fetal brain:in vitro MR study with histologic comparison显示文摘 | Brisse H Fallet C Sebag G | 1997 | AJNR1997，18，： | 1 |
| 20 | Cortical radial glial cells in human fetuses:depth-correlated transformation into astrocytes显示文摘 | Deazevedo LC Fallet C Moura NV | 2003 | J Neurobiol2003，55，3： | 1 |
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