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| 1 | Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases显示文摘AIM: To investigate the impact of RAS and BRAF mutations on the pattern of metastatic disease and carcinoembryonic antigen(CEA) production.METHODS: In this retrospective study, we investigated the impact of RAS and BRAF mutational status on pattern of metastatic disease and CEA production. Only patients presenting with a newly diagnosed metastatic colorectal cancer(CRC) were included. Patients' characteristics, primary tumor location, site of metastatic disease and CEA at presentation were compared between those with and without RAS and BRAF mutations.RESULTS: Among 174 patients, mutations in KRAS, NRAS and BRAF were detected in 47%, 3% and 6% respectively. RAS mutations(KRAS and NRAS) were more likely to be found in African American patients(87% vs 13%; P value = 0.0158). RAS mutations were associated with a higher likelihood of a normal CEA(< 5 ng/mL) at presentation. BRAF mutations were more likely to occur in females. We were not able to confirm any association between mutational status and site of metastatic disease at initial diagnosis.CONCLUSION: No association was found between RAS and BRAF mutations and sites of metastatic disease at the time of initial diagnosis in our cohort. Patients with RAS mutations were more likely to present with CEA levels < 5 ng/mL. These findings may have clinical implications on surveillance strategies for RAS mutant patients with earlier stages of CRC. | may cho chie akiba cecilia lau david smith milhan telatar michelle afkhami stephen sentovich kurt melstrom marwan fakih | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 2 | Interinstitutional and intrainstitutional transmission of a strain of Acineto- bacter baumanniidetected by molecular analysis: compari- son of pulsed-field gel electrophoresis and repetitive se- quence-based polymerase chain reaction 显示文摘 | Saeed S Fakih M G Riederer K | 2006 | Infect Con- trol Hosp Epidemiol2006，27，9： | 1 |
| 3 | Interinstitutional and intrain- stitutional transmission of a strain of Acinetobacter baumannii detected by molecular analysis: comparison of pulsed -field gel electrophoresis and repetitive sequence - based polymerase chain reaction 显示文摘 | Saeed S Fakih MG Riederer K | 2006 | Infect Control Hosp Epidemiol2006，27，9： | 1 |
| 4 | Strategies to prevent central line-associated bloodstream infections in acute care hospitals : 2014 update 显示文摘 | Marschall J Mermel LA Fakih M | 2014 | Infect Control Hosp Epidemiol2014，35，12： | 1 |
| 5 | Peripherally inserted central venous catheters in the acute care setting:A safe alternative to high risk short-term central venous catheters显示文摘 | AI Raiy B Fakih MG Bryan-Nomides N | 2010 | AmJ Infect Control2010，38，2： | 1 |
| 6 | Bowel habits and toilet training in rural and urban dwelling children in a developing country显示文摘 | Aziz S Moiz Fakih H A Di Lorenzo C | 2011 | J Pediatr2011，158，5： | 1 |
| 7 | Very early transvaginal embryo aspiration:a safe and effective method formultifetal pregnancy reduction显示文摘 | Massad ZC Gill I Fakih MH | 2000 | Fertil Steril2000，74，： | 1 |
| 8 | Elective versus therapeutic neck dissection in early carcinoma of the oral tongue显示文摘 | Fakih AR Rao RS Borges AM | 1989 | Am J Surg1989，158，4： | 1 |
| 9 | Suceess rate, quality of life,and descriptive analysis after generalized endometrial ablation in an obese population显示文摘 | Fakih M Cherfan V Abdallah E | 2011 | Int J Gynaecol Obstet2011，113，2： | 1 |
| 10 | Peripherally inserted central venous catheters in the acute care setting:A safe alternative to high-risk short-term central venous catheters显示文摘 | Al Raiy B Fakih MG Bryan-Nomides N | 2010 | Am J Infect Control2010，38，2： | 1 |
| 11 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 12 | 5-fluorouracil leucovorin and oxaliplatin (FOLFOX) in the treatment of metastatic colon cancer with severe liver dysfunction显示文摘 | Fakih MG | 2004 | Ontology2004，67，324： | 1 |
| 13 | Sustained improve- ments in peripheral venous catheter care in non-intensive care units:a quasi-experimental controlled study of edu- cation and feedback显示文摘 | Fakih MG Jones K Rey JE | 2012 | Infect Control Hosp Epidemiol2012，33，5： | 1 |
| 14 | Strategies to prevent central line - associated bloodstream infections in acute care hospitals :2014 update显示文摘 | Marschall J Mermel LA Fakih M | 2014 | Infect Control Hosp Epidemiol2014，35，7： | 1 |
| 15 | Cetuximab-induced hypomagnesemia in patients with colorectal cancer 显示文摘 | Fakih MG Wilding G Lombardo J | 2006 | Clin Colorectal Cancer2006，6，2： | 1 |
| 16 | Significance of Signet-Ring Cells in Patients with Colorectal Cancer显示文摘 | Rashmi Pande M.S. Annette Sunga M.D. M.P.H. Charles LeVea M.D. Gregory E. Wilding Ph.D. Wiam Bshara M.D. Mary Reid Ph.D. Marwan G. Fakih M.D | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
| 17 | Strategies to prevent central line-associated bloodstream infections in acute care hospitals:2014 update显示文摘 | Marschall J Mermel LA Fakih M | 2014 | Infection Control2014，35，7： | 1 |
| 18 | Carpometacarpal dislocation producing transient motor neurapraxia of the ulnar nerve显示文摘 | Pimpalnerkar AL Fakih R Thomas AP | 1997 | Injury1997，28，56： | 1 |
| 19 | Success rate,quality of life,and descriptive analysis after generalized endometrial ablation an obese population显示文摘 | Fakih M Cherfan V Abdallah E | 2011 | Interna J Gynecol Obstetr2011，113，2： | 1 |
| 20 | Sustained Improvements in Peripheral Venous Catheter Care in Non-intensive Care Units: a Quasi- experimental Controlled Study of Education and Feedback显示文摘 | Fakih M G Jones K Rey J E | 2012 | Infect Control HospEpidemiol2012，33，5： | 1 |
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