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| 1 | Role of NK, NKT cells and macrophages in liver transplantation显示文摘Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer(NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review. | René Fahrner Felix Dondorf Michael Ardelt Utz Settmacher Falk Rauchfuss | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 2 | Liver transplantation for hepatocellular carcinoma- factors influencing outcome and disease-free survival显示文摘Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. However, there are several factors that influence disease-free survival after transplantation. This review addresses the pre-, intra- and postoperative factors that influence the risk of tumor recurrence after liver transplantation. | René Fahrner Felix Dondorf Michael Ardelt Yves Dittmar Utz Settmacher Falk RauchfuB | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 3 | Risk of malignancy in Caroli disease and syndrome: A systematic review显示文摘BACKGROUND Congenital intrahepatic bile duct dilatation without fibrosis is called Caroli disease(CD),and is called Caroli syndrome(CS)when it has fibrotic and cirrhotic liver morphology.The development of intrahepatic carcinoma is described in both conditions,but the reported incidence varies extensively.Potential risk factors for the malignant transformation were not described.Furthermore,conservative or surgical treatment is performed depending on the extent of cystic malformation,hepatic dysfunction and structural hepatic changes,but little is known about which treatment should be offered to patients with CD or CS and cancer.AIM To further investigate the malignant transformation in these conditions.METHODS A systematic review of the current literature until January 2019 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.A search using Medline(PubMed)was performed using a combination of Medical Subject Headings terms“caroli disease”,“caroli syndrome”,“tumor”,“malignant”,and“cholangiocarcinoma”.Only human studies published in English were used for this systematic review.The following parameters were extracted from each article:year of publication,type of study,number of patients,incidence of malignant tumor,duration of symptoms,age,sex,diagnostics,identification of tumor,surgical therapy,survival and tumor recurrence.RESULTS Twelve retrospective studies reporting the courses of 561 patients(53%females)were included in this systematic review.With a mean age of 41.6 years old(range 23 to 56 years old),patients were younger than other populations undergoing liver surgery.Depending on the size of the study population the incidence of cholangiocarcinoma varied from 2.7%to 37.5%with an overall incidence of 6.6%.There were only few detailed reports about preoperative diagnostic work-up,but a multimodal work-up including ultrasound of the liver,computed tomography,magnetic resonance imaging and endoscopic retrograde cholangiopancreatography was used in most studies.Disease duration was variable with up to several years.Most patients had episodes of cholangitis,sepsis,fever or abdominal pain.Tumor detection was an incidental finding of the surgical specimen in most cases because it is currently often impossible to detect tumor manifestation during preoperative diagnostics.Liver resection or liver transplantation was performed depending on the extent of the biliary pathology and additional alterations of the liver structure or function.No postoperative adjuvant chemotherapy was reported,but chemotherapy was administered in selected cases of tumor recurrence.Overall survival rates after one year were low at 36%and a high recurrence rate of up to 75%during the observation period.CONCLUSION Only few retrospective studies reported a low tumor incidence.Despite the high rate of mortality and tumor recurrence,definite surgical treatment should be offered as soon as possible. | Rene Fahrner Sandra GC Dennler Daniel Inderbitzin | 2020 | World Journal of Gastroenterology2020，26，31： | 2 |
| 4 | Thickness Dependence of Resistivity and Optical Reflectance of ITO Films显示文摘在水晶的硅晶片和 Corning 玻璃上扔的 Indium-tin-oxide (ITO ) 电影被直流的磁控管劈啪作响准备在有各种各样的厚度的房间温度的方法。结构,电阻和 ITO 电影的光反射的厚度依赖被描绘。结果证明当电影厚度是不到 40 nm 时,抵抗力和 ITO 的光反射与厚度显著地拍摄变化。optoelectrical 性质趋势将当厚度在 55nm 上时,稳定。GXRD 结果暗示 ITO 电影开始真希望结晶厚度足够大。 | 高美珍 薛德胜 FAHRNER W R | 2008 | Chinese Physics Letters2008，25，4： | 2 |
| 5 | Factorial screening of antibody purification processes using three chromatography steps without protein A显示文摘 | Follman D K Fahrner R L | 2007 | Journal of Chromatography A2007，1024，1： | 1 |
| 6 | The NGFI-B protein,an inducible member of the thyroid/steroid receptor family is rapidly modified posttranslationally显示文摘 | Fahrner TJ Carroll SL Milbrandt J | 1990 | Mol Cell Biol1990，10，12： | 1 |
| 7 | On Almost Sure Max-limit Theorems显示文摘 | Fahrner I Stadtmüller U | | 0，，： | 1 |
| 8 | Factorial screening of antibody purification processes using three chromatography steps without Protein A显示文摘 | Follman DK Fahrner RL | 2004 | J Chromatogr A2004，1024，12： | 1 |
| 9 | On almost sure mar-limit theorems显示文摘 | FAHRNER I STATM(U)LLER U | 1998 | Statist Probab Letters1998，37，3： | 1 |
| 10 | Effects of endurance exercise on free testosterone concentration and the binding affinity of sex hormone binding globulin (SHBG)显示文摘 | Fahrner C L Hackney A C | 1998 | Int J Sports Med1998，19，： | 1 |
| 11 | Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus mediated gene transfer显示文摘 | Pickles R J Fahrner J A Petrella J M Boucher R C Bergelson J M | 2000 | J Virol2000，74，： | 1 |
| 12 | On Almost Sure Max-limit Theorems显示文摘 | Stadtmüller U | 1998 | Statist Probab Lett1998，37，3： | 1 |
| 13 | Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients显示文摘 | FAHRNER A KANN G FLUBACHER A | 2007 | Exp Neurol2007，203，2： | 1 |
| 14 | Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state 显示文摘 | McGarvey KM Fahrner JA Greene E | 2006 | Cancer Res2006，66，7： | 1 |
| 15 | Dependence of histone modifications and gene expres- sion on DNA hypermet- hylation in cancer显示文摘 | FAHRNER J A EGUCHI S HERMAN J G | 2002 | Cane- er Res2002，62，： | 1 |
| 16 | Industrial purifica- tion of pharmaceutical antibodies: development, operation, and validation of chromatography processes 显示文摘 | Fahrner RL Knudsen HL Basey CD et ol | 2001 | Biotechnol Genet Eng Rev2001，18，1： | 1 |
| 17 | A Cytosolic Homomerization and a Modμlatory Domain within STIM1 C Terminus Determine Coupling to Orai1 Channels显示文摘 | Muik M Fahrner M Derler I | | 0，，： | 1 |
| 18 | Elevated liver re generation in response to pharmacological reduction of elevated portal venous pressure by terlipressin after partial hepatectomy 显示文摘 | Fahrner R Patsenker E de Gottardi A | 2014 | Transplantation2014，97，9： | 1 |
| 19 | On Almost Sure Max-Limit Theorems 显示文摘 | Fahrner I Stadtmiiller U | 1998 | Statist Probab Lett f 19981998，，： | 1 |
| 20 | Review on materials, microsensors, systems, and devices for high-temperature and harsh environment applications 显示文摘 | WERNER M R FAHRNER W R | 2001 | IEEE Transaction on electronics2001，48，2： | 1 |
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