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| 1 | Non-surgical treatment of hilar cholangiocarcinoma显示文摘Cancer of the biliary confluence also known as hilar cholangiocarcinoma(HC)or Klatskin tumor,is a rare type of neoplastic disease constituting approximately 40%-60%of intrahepatic malignancies,and 2% of all cancers.The prognosis is extremely poor and the majority of Klatskin tumors are deemed unresectable upon diagnosis.Most patients with unresectable bile duct cancer die within the first year after diagnosis,due to hepatic failure,and/or infectious complications secondary to biliary obstruction.Curative treatments include surgical resection and liver transplantation in highly selected patients.Nevertheless,very few patients are eligible for surgery or transplant at the time of diagnosis.For patients with unresectable HC,radiotherapy,chemotherapy,photodynamic therapy,and liver-directed minimally invasive procedures such as percutaneous image-guided ablation and intra-arterial chemoembolization are recommended treatment options.This review focuses on currently available treatment options for unresectable HC and discusses future perspectives that could optimize outcomes. | Riccardo Inchingolo Fabrizio Acquafredda Valentina Ferraro Letizia Laera Gianmarco Surico Alessia Surgo Alba Fiorentino Stefania Marini Nicola de'Angelis Riccardo Memeo Stavros Spiliopoulos | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 5 |
| 2 | Economics language and assumptions: HOW theory can become self-fulfilling 显示文摘 | Fabrizio Ferraro Jeffery Pfeffer and Robert I Sutton | 2005 | Academy of Management Review2005，30，1： | 1 |
| 3 | Planktonic foraminifera as bio-indicators for monitoring the climatic changes that have occurred over the past 2000 years in the southeastern Tyrrhenian Sea显示文摘A high-resolution integrated study has been performed in a super-expanded marine record(sedimentation rate spanning from 11 cm/100 years to 20 cm/100 years)from the continental shelf area of the southeastern Tyrrhenian Sea.Planktonic foraminiferal distribution illustrates 6 major environmental changes during the past 2000 years:(i)the Roman Period-Dark Age transition(from herbivorous-opportunistic to carnivorous species);(ii)the Dark Age-MCA transition(from carnivorous to herbivorous-opportunistic species);(iii)the Medieval Classic Anomaly-Little Ice Age transition(a further and definitive change from carnivorous to herbivorous-opportunistic species);(iv)the period during the Maunder event between approximately 1720 AD and 1740 AD(turnover from the carnivorous planktonic foraminifer Globigerinodes ruber to the herbivorous-opportunistic planktonic foraminifer Turborotalita quinqueloba);(v)the Industrial Period(dominance of herbivorous-opportunistic planktonic foraminifera);and(vi)the Modern Warm Period at approximately 1940 AD(the last turnover in favor of herbivorous-opportunistic planktonic foraminifers,associated with an increase in benthic foraminifera).Our studies lead us to link this latter feature to an anthropogenic impact associated with the damming of Sele River(Salerno Gulf)at 1934 AD,which induced a change in the sediment input with a strong decrease in coarse-grained fraction and a probable alteration in nutrient supply.Theδ^(18)O_(G.ruber) record of the past 2000 years shows the alternation of warm/wet and cold/dry events related to the Roman Period,the Dark Age,the Medieval Classic Anomaly,the Little Ice Age,the Industrial Period and the Modern Warm Period.The 5 evidentδ^(18)O_(G.ruber) oscillations(between approximately 1325 AD and 1940 AD)coincide with the 5 minima in the solar activity record(Wolf,Spörer,Maunder,Dalton and Damon events). | Fabrizio LIRER Mario SPROVIERI Mattia VALLEFUOCO Luciana FERRARO Nicola PELOSI Laura GIORDANO Lucilla CAPOTONDI | 2014 | Integrative Zoology2014，9，4： | 0 |
| 4 | Review on TNSA diagnostics and recent developments at SPARC LAB显示文摘Interaction between high-intensity lasers with solid targets is the key process in a wide range of novel laser-based particle accelerator schemes,as well as electromagnetic radiation sources.Common to all the processes is the generation of femtosecond pulses of relativistic electrons emitted from the targets as forerunners of the later-time principal products of the interaction scheme.In this paper,some diagnostics employed in laser–solid matter interaction experiments related to electrons,protons,ions,electromagnetic pulses(EMPs)and X-rays are reviewed.Then,we present our experimental study regarding fast electrons and EMPs utilizing a femtosecond-resolution detector previously adopted only in accelerator facilities. | Fabrizio Bisesto Mario Galletti Maria Pia Anania Massimo Ferraro Riccardo Pompili Mordechai Botton Elad Schleifer Arie Zigler | 2019 | High Power Laser Science and Engineering2019，7，3： | 0 |
| 5 | Percutaneous insertion of a novel dedicated metal stent to treat malignant hilar biliary obstruction显示文摘BACKGROUND Percutaneous bilateral biliary stenting is an established method for the management of unresectable malignant hilar biliary obstruction.AIM To evaluate the efficacy and safety of a novel uncovered biliary stent, specifically designed for hilar reconstruction.METHODS This, single-center, retrospective study included 18 patients(mean age 71 ± 11 years;61.1% male) undergoing percutaneous transhepatic Moving cell stent(MCS) placement for hilar reconstruction using the stent-in-stent technique for malignant biliary strictures, between November 2020 and July 2021. The Patients were diagnosed with cholangiocarcinoma(12/18;66.6%), gallbladder cancer(5/18;27.7%), and colorectal liver metastasis(1/18;5.5%). Primary endpoints were technical(appropriate stent placement) and clinical(relief from jaundice) success. Secondary endpoints included stent patency, overall survival, complication rates and stent-related complications.RESULTS The technical and clinical success rates were 100%(18/18 cases). According to Kaplan-Meier analysis, the estimated overall patient survival was 80.5% and 60.4% at 6 and 12 mo respectively, while stent patency was 90.9% and 68.2% at 6 mo and 12 mo respectively. The mean stent patency was 172.53 ± 56.20 d and median stent patency was 165 d(range 83-315). Laboratory tests for cholestasis significantly improved after procedure: mean total bilirubin decreased from 15.2 ± 6.0 mg/d L to 1.3 ± 0.4 mg/d L(P < 0.001);mean γGT decreased from 1389 ± 832 U/L to 114.6 ± 53.5 U/L(P < 0.001). One periprocedural complication was reported. Stent-related complications were observed in 5 patients(27.7%), including 1 occlusion(5.5%) and 1 stent migration(5.5 %).CONCLUSION Percutaneous hilar bifurcation biliary stenting with the MCS resulted in excellent clinical and technical success rates, with acceptable complication rates. Further studies are needed to confirm these initial positive results. | Francesco Cortese Fabrizio Acquafredda Andrea Mardighian Maria Teresa Zurlo Valentina Ferraro Riccardo Memeo Stavros Spiliopoulos Riccardo Inchingolo | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 0 |
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