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| 1 | A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway显示文摘 | Mullenders J Fabius AW Madiredjo M | | 0，，03： | 1 |
| 2 | Relation between industrialization and the distribution and growth of epiphytic lichens and mosses in montreal显示文摘 | FABIUS LEBLANC S C de SHOOVER J | 1970 | Can J Bot1970，48，8： | 1 |
| 3 | Untersuchungen über die Polyploidie und die Variabilit?t beiArtemia salina显示文摘 | Fabius Gross | 1932 | Die Naturwissenschaften1932，，51： | 1 |
| 4 | A large scale shRNA bareode screen identifies the circadian clock component ARNTL as pu- tative regulator of the p53 tumor suppressor pathway 显示文摘 | Mullenders J Fabius A W Madiredjo M | 2009 | PLoS One2009，4，3： | 1 |
| 5 | Improving TCP performance inAd hoc networks using signal strength based link management显示文摘 | FABIUS K ZHEQIANG Y SRKANTH K | 2005 | Ad hoc Networks2005，3，2： | 1 |
| 6 | An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors显示文摘 | Fabius AW Mullenders J Madiredjo M Velds A Kerkhoven RM Bernards R Beijersbergen RL | 2006 | Nat Chem Biol2006，2，： | 1 |
| 7 | In Situ Cell for Combined XRD and On-Line Catalysis Tests: Studies of Cu- Based Water Gas Shift and Methanol Catalysts 显示文摘 | Clausen B S Steffensen G Fabius B | 1991 | J Catal1991，132，2： | 1 |
| 8 | 显示文摘 | Brummelkamp TR Fabius AW Mullenders J | 2006 | Nat Chem Biol2006，2，4： | 1 |
| 9 | Efficient induction of differentiation and growth inhibition in IDRI mutant glioma cells by the DNMT Inhibitor Decitabine显示文摘 | Turcan S Fabius A W Borodovsky A | | Oncotarget0，4，10： | 1 |
| 10 | Alarge scale shRNA barcode screen identifies the circadian clockcomponent ARNTL as putative regulator of the p53 tumor sup-pressor pathway显示文摘 | MULLENDERSJ FABIUS AWM MADIREDJO M | 2009 | PLoS One2009，4，3： | 1 |
| 11 | A regenerative anemia of the newborn (Kaznelson-Baar type)显示文摘 | LORENZO Y DE IBARRETA J FABIUS S GONZALEZ CARDONA J | 1959 | [Article in Spanish] Arch Pediatr Urug1959，30，： | 1 |
| 12 | Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine 显示文摘 | Turcan S Fabius AW Borodovsky A | 2013 | Oncotarget2013，4，10： | 1 |
| 13 | Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine 显示文摘 | Turcan S Fabius AW Borodovsky A | 2013 | Oncotarget2013，4，10： | 1 |
| 14 | Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data?显示文摘BACKGROUND According to the result of the Cochrane review published in 2012,postoperative adjuvant chemotherapy(CTx)is associated with a survival benefit for rectal cancer patients operated for cure in comparison to patients who underwent only the surgical resection.AIM To analyze the quality of the data supporting the advantage of adjuvant CTx after surgery for rectal cancer.In the times of increasing health care costs,it is imperative to offer the patient an evidence-based therapy that justifies potential side effects as well as costs.METHODS Overall survival was selected as endpoint of interest.Among the 21 included papers which analyzed this endpoint,we identified those three publications which have the highest weights to influence the final result.The validity of these papers was analyzed using the CONSORT checklist for randomized controlled trials.We performed a second meta-analysis excluding the three analyzed studies(n=18)in order to assess their impact on the overall result of the original metaanalysis.Finally,we performed a third meta-analysis excluding all studies(n=16)which showed a statistically improved overall survival.RESULTS The detailed analysis of the three most relevant RCTs according to the items of the CONSORT checklist showed several pitfalls.In up to 47%of the items,inappropriate answers were found.Generally,a lack of information regarding therandomization procedure as well as the absence of allocation concealment,blinded set-up,of intention-to-treat analysis and omission of sample size calculation were common problems of the analyzed studies.The exclusion of these three studies from the meta-analysis did not affect the general result of the meta-analysis,still confirming a survival advantage after adjuvant chemotherapy.After exclusion of single studies with a statistically significant outcome improvement,the meta-analysis of the remaining 16 studies again shows a statistically significant result due in part to a large remaining sample size.CONCLUSION The three most powerful publications show substantial deficits.We suggest a more critical appraisal regarding the validity of single studies because a metaanalysis cannot overcome the limitations of individual trials by pooling treatment effect estimates to generate a single best estimate. | Giulia Manzini Fabius Hapke Ian N Hines Doris Henne-Bruns Michael Kremer | 2020 | World Journal of Gastrointestinal Oncology2020，12，4： | 0 |
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