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| 1 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 2 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 3 | Molecuar characterization ofa carboxy-terminal cell-binding dimain of intimin from enteropathogeicEscherichia coli 显示文摘 | Frankel G Candy D C A Fabiani E | 1995 | Infection and Immunity1995，63，： | 1 |
| 4 | Power Electronics and Electrical Insulation Systems-Part 1: Phenomenology Over- view显示文摘 | CavaUini A Fabiani D Carlo M G | 2010 | IEEE Electrical Insulation Magazine2010，26，3： | 1 |
| 5 | Evi-dence of leaflet injury during percutaneous aortic valvedeployment显示文摘 | Zegdi R Bruneval P Blanchard D Fabiani J N | 2011 | Eur J Cardiothorac Surg2011，40，： | 1 |
| 6 | Modification of electrical properties and performance of EVA and PP insulation through nanostructure by organophilic silicates显示文摘 | Montanari G C Fabiani D Palmieri F | | 0，，05： | 1 |
| 7 | Diagnostic and therapeutic laparoscopy for stab wounds of the anterior abdomen显示文摘 | Fabiani P Iannelli A Mazza D | 2003 | Laparoendosc Adv Surg Tech A2003，13，5： | 1 |
| 8 | Relation between space charge accumulation and partial discharge activity in enameled wires under PWM-like voltage waveforms显示文摘 | Fabiani D Montanari G C Contin A | 2004 | IEEE Transactions on Dielectrics and Electrical Insulation2004，11，3： | 1 |
| 9 | HVDCCable design and space charge accumulation part 3 : effect oftemperature gradient 显示文摘 | FABIANI D MONTANARI GC LAURENT C | 2008 | IEEE Electrical Insulation Magazine2008，24，2： | 1 |
| 10 | Diagnostic and therapeutic laparoseopy for stab wounds of the anterior abdomen显示文摘 | Fabiani P Innnelli A Mazza D | 2003 | J Laparoendosc Adv Surg Tech A2003，13，5： | 1 |
| 11 | A UHF Technique for Advanced PD Measurements on Inverter-fed Motors显示文摘 | Fabiani D Cavallini A Montanari G C | 2008 | IEEE Transactions on Power Electronics2008，23，5： | 1 |
| 12 | Evaluation of Dc Insulation Performance Based on Space-charge Measurements and Accelerated Life Tests显示文摘 | Montanari G C Fabiani D | 2000 | IEEE Transactions on Dielectrics and Electrical Insulation2000，7，3： | 1 |
| 13 | Relation between space charge accumulation and partial discharge activity in enameled wires under PWM like voltage waveforms显示文摘 | Fabiani D Montanari G C Cavallini A | 2004 | IEEE Transactions on Dielectrics and Electrical Insulation2004，11，3： | 1 |
| 14 | Relation Between Space Charge Accumulation and Partial Discharge Activity in Enameled Wires Under PWM-like Voltage Waveforms显示文摘 | Fabiani D Montanari G C Cavallini A | 2004 | IEEE Transactions on Dielectrics and Electrical Insulation2004，11，3： | 1 |
| 15 | Evaluation insulation performance based on space of DC charge measurements and accelerated life tests显示文摘 | Montanari G C Fabiani D | 2000 | IEEE Transactions on Dielectrics and Electrical Insulation2000，7，3： | 1 |
| 16 | Distribution and prevalence of inducible nitric oxide synthase in atherosclerotic vessles of long-term cholesterol-fed rabbits显示文摘 | Behr D Rupin A Fabiani JN | 1999 | Atherosclerosis1999，142，： | 1 |
| 17 | Discussion on application of the weibull distribution to electrical breakdown of insulating materials显示文摘 | Fabiani D | 2005 | IEEE Transactions on Dielectrics and Electdcal Insulation2005，12，1： | 1 |
| 18 | Relation between space charge accumulation and partial discharge activity in enameled wires under PWM-like voltage waveforms显示文摘 | Fabiani D Montanari G C Cavallini A | 2004 | IEEE Transactions on Dielectrics and Electrical Insulation2004，11，3： | 1 |
| 19 | Power Electronics and Electrical Insulation Systems-Part 3: Diagnostic Proper- ties显示文摘 | Cavallini A Fabiani D Montanari G C | | lEEE Electrical Insulation Magazine0，26，5： | 1 |
| 20 | Relation between space charge accumulation and partial discharge activity in enameled wires under PWM-like voltage waveforms显示文摘 | Fabiani D Montanari G C Cavallini A | 2004 | IEEE Transaction on Dielectrics and Electrical Insulation2004，11，3： | 1 |
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