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	题名	作者	年代	出处	被引量
1	Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC.	Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove	2014	World Journal of Gastroenterology2014，20，4：	2
2	Log-Add approximation on-line noise compensation method adopting robust decision rules for robust digits recognition 显示文摘	Yao K S Bertram E Shi Fung P	2000	Chinese Journal of Electronics2000，9，3：	2
3	Improved measurements of the erythrocyte geometry显示文摘	Evans E Fung Y C	1972	Microvasc Res1972，，4：	1
4	Application of principal components analysis change detection 显示文摘	Fung T LeDrew E	1987	Photogrammetric Engineering and Remote Sensing1987，53，12：	1
5	Current achievements using ProteinChip Array technology显示文摘	Weinberger S R Dalmasso E A Fung E T	2002	Curr Opin Chem Biol2002，6，1：	1
6	GRIP:a synaptic PDZ domain-containing protein that interacts with AMPA receptors显示文摘	Dong H O'Brien R J Fung E T	1997	Nature1997，386，6622：	1
7	Delta-like 4 induces Notchsignaling in macrophages : implications for inflammation 显示文摘	Fung E Tang SM Canner JP	2007	Circulation2007，115，23：	1
8	Higher-order multivariate Markov chains and their applications显示文摘	Ching W K Ng M K Fung E S	2008	Linear Algebra and its Applications2008，428，2：	1
9	Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides显示文摘	Lin F Ooi V E C Fung M C	1999	Life Sciences Including Pharmacology Letters1999，64，12：	1
10	The international intravitreal bevacizumab safety survey: Using the internet to assess drug safety worldwide 显示文摘	Fung AE Rosenfeld PJ Reichel E	2006	Br J Ophthalmol2006，90，11：	1
11	Information flows across markets: evidence from China-backed stocks dual-listed in Hong Kong and New York显示文摘	XU X E FUNG H G	2002	the Financial Review2002，37，：	1
12	Higher-order multivariate Markov chains and their applications显示文摘	Ching W K Ng M K Fung E S	2008	Linear Algebra and its Applica- tions2008，428，2：	1
13	Prediction of breast cancer size by ultrasound,mammography,and core biopsy 显示文摘	Fung BB Wiley E	2004	Breast2004，13，4：	1
14	The determination of optimal threshold levels for changes detection using various accuracy indices显示文摘	Fung T and Ledrew E	1988	Photogrammetric Engineering and Remote Sensing1988，54，10：	1
15	A biomarker panel for peripheral arterial disease显示文摘	Fung E T Wilson A M Zhang F Harris N Edwards K A Olin J W	2008	Vasc Med2008，13，：	1
16	Delta-Like 4 induces notch signaling in macrophages : implications for inflammation 显示文摘	Fung E Tang SM Canner JP	2007	Circulation2007，115，23：	1
17	Estimation of the basic reproduction number of enterovirus 71 and coxsackie virus A16 in hand, foot and mouth disease outbreaks 显示文摘	Ma E Fung C Yip SH	2011	Pediatr Infect Dis J2011，30，8：	1
18	Chromosomal aberrations of primary lung adenocarcinomas in nonsmokers显示文摘	WONG M P FUNG L F WANG E	2003	Cancer2003，97，5：	1
19	The potential use of type-5 phosphodiesterase inhibitors in coronary artery bypass graft surgery显示文摘	Fung E Fiscus RR Yim AP	2005	Chest2005，128，4：	1
20	Delta like 4 induces notch signaling in macro phages:implications for inflammation显示文摘	FUNG E TANG S M CANNER J P	2007	Circulation2007，115，23：	1

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