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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease显示文摘BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)refers to any fatty liver disease that is not due to excessive use of alcohol.NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance.Aerobic exercise is shown to improve NAFLD.This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.DATA SOURCE:We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub Med. | Rui Guo Emily C Liong Kwok Fai So Man-Lung Fung George L Tipoe | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 16 |
| 3 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 4 | 完全叠接管节点在低周循环载荷下的破坏模式研究显示文摘采用实验和数值模拟方法研究了一种新型海洋平台管节点在地震载荷下的响应和破坏情况。采用拟静态循环加载模拟地震载荷 ,对真实尺寸的试件进行实验 ,研究局部屈曲和裂纹等对管接点抗震性能的影响。能量分析表明 ,发生在斜支管中的局部屈曲消耗了大部分输入能量。与现在使用的N型管节点相比 ,该新型管节点有较好的抗震性能。采用有限元数值模拟方法分析比较了不同尺寸配置下 。 | 秦飞 GHO W M FUNG TC Soh C K | 2002 | 海洋工程2002，20，1： | 7 |
| 5 | Practice of breast self-examination among high risk Chinese women in Hong Kong显示文摘The incidence of breast cancer in Hong Kong is increasing and breast self examination (BSE) as a screening tool is becoming more popular, especially among first degree relatives (FDR) of breast cancer victims BSE may be more applicable to Chinese women as their breast size is smaller This study explores the BSE practice in this group of women Methods A cross sectional study was conducted by sending questionnaires to 330 FDR of breast cancer patients treated in the Department of Surgery, University of Hong Kong BSE behavior was studied with respect to its frequency, awareness, completeness and confidence of practice Results 110 subjects returned the questionnaires with a response rate of 33% The mean age of the respondent was 37 years Only 57 women (52%) were practicers The practicers have a stronger BSE awareness ( P <0 01) and a lower mean score on thought barriers ( P =0 002) than the non practicers 40% of the practicers gain their BSE knowledge through clinicians and their mean period of practice was 3 2 years 68% of the practicers performed BSE completely The overall confidence rate was 35%, but the rate was 43% among those who performed complete BSE Thirteen factors possibly related to the completeness and rate of confidence of BSE examination were studied The only factor that significantly determined completeness was the time spent for each examination ( P =0 002) The complete practicers required a longer time than the incomplete practicers (6 60 and 2 96?min, respectively) Women with a stronger BSE intention ( P =0 001) and a lower mean score on thought barriers ( P =0 001) performed the examination confidently Conclusions Slightly over half of the FDR practice BSE The majority perform a complete BSE but they are not confident in finding abnormalities Women spending more time on BSE are associated with a higher rate of completeness However, only those with a stronger BSE intention and lesser thought barriers are more confident in their | Kelvin K C Ng, Fung S Y and Louis W C Chow DepartmentofSurgery (NgKKCandChowLWC)&NursingStudies (FungSY ) ,TheUniversityofHongKong ,QueenMaryHospital ,HongKong ,China | 2000 | Chinese Medical Journal2000，，12： | 4 |
| 6 | Contribution of vacuum field to angular deviation of light path and radar echo delay 显示文摘 | Lu H Q Fung P C W | 1997 | Astrophysics and Space Science1997，253，： | 2 |
| 7 | Improved measurements of the erythrocyte geometry显示文摘 | Evans E Fung Y C | 1972 | Microvasc Res1972，，4： | 1 |
| 8 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
| 9 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 10 | A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging 显示文摘 | YU C M ZHANG Q FUNG J W | 2005 | J Am Coll Cardiol2005，45，5： | 1 |
| 11 | Optimization of an impact drive mechanism based on real-coded genetic algorithm显示文摘 | Ha J L Fung R F Han C F | | 0，，02： | 1 |
| 12 | Optimizing Timetable Synchronization for Rail Mass Transit 显示文摘 | Wong R C W Yuen T W Y Fung K W | 2008 | Transportation Sci- ence2008，42，1： | 1 |
| 13 | Cellular and molecular mechanisms of pulmonary vascular remodeling:role in the development of pulmonary hypertension显示文摘 | MANDEGAR M FUNG Y C HUANG W | 2004 | Microvasc Res2004，68，2： | 1 |
| 14 | A biological survey of' ballast water in container ships entering Hong Kong显示文摘 | CHU K H TAM P F FUNG C H | 1997 | Hydrobiologia1997，352，1： | 1 |
| 15 | Psychometric properties of the Chinese version of the mini-mental adjustment to cancer (MINI-MAC) scale显示文摘 | Ho S M Y Kam Fung W Chan C L W | 2003 | Psycho Oncol2003，12，6： | 1 |
| 16 | Short-term effects of nicotine on bone and calciotropic hormones in adult female rats显示文摘 | FUNG Y K MENDLIK M G HAVEN M C | 1998 | Pharmacol Toxicol1998，82，2： | 1 |
| 17 | Relationship between atmospheric CO2 variations and a satellite-derives vegetation index显示文摘 | Tucker C J Fung I Y Keeling C D | 1986 | Nature1986，319，： | 1 |
| 18 | Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides显示文摘 | Lin F Ooi V E C Fung M C | 1999 | Life Sciences Including Pharmacology Letters1999，64，12： | 1 |
| 19 | Cellular and molecular mechanisms of pulmonary vascular remode- ling:role in the development of pulmonary hyperten sion显示文摘 | Mandegar M Fung Y C Huang W | 2004 | Microvasc Res2004，68，2： | 1 |
| 20 | Microbiological study of tofu 显示文摘 | Tuitemwong K Fung D Y C | 1991 | Journal of food Protection1991，54，13： | 1 |
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