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| 1 | Anti program death-1/anti program death-ligand 1 in digestive cancers显示文摘Human tumors tend to activate the immune system regulatory checkpoints as a means of escaping immunosurveillance. For instance, interaction between program death-1(PD-1) and program death-ligand 1(PD-L1) will lead the activated T cell to a state of anergy. PD-L1 is upregulated on a wide range of cancer cells. Anti-PD-1 and anti-PD-L1 monoclonal antibodies(m Abs), called immune checkpoint inhibitors(ICIs), have consequently been designed to restore T cell activity. Accumulating data are in favor of an association between PD-L1 expression in tumors and response to treatment. A PD-L1 expression is present in 30% to 50% of digestive cancers. Multiple anti-PD-1(nivolumab, pembrolizumab) and anti-PD-L1 m Abs(MPDL3280A, Medi4736) are under evaluation in digestive cancers. Preliminary results in metastatic gastric cancer with pembrolizumab are highly promising and phase Ⅱ will start soon. In metastatic colorectal cancer(CRC), a phase Ⅲ trial of MPDL3280 A as maintenance therapy will shortly be initiated. Trials are also ongoing in metastatic CRC with high immune T cell infiltration(i.e., microsatellite instability). Major challenges are ahead in order to determine how, when and for which patients we should use these ICIs. New radiologic criteria to evaluate tumor response to ICIs are awaiting prospective validation. The optimal therapeutic sequence and association with cytotoxic chemotherapy needs to be established. Finally, biomarker identification will be crucial to selection ofpatients likely to benefit from ICIs. | Eléonore de Guillebon Pauline Roussille Eric Frouin David Tougeron | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 12 |
| 2 | 湖南烟溪病圃稻瘟病菌的有性态及微卫星标记的遗传多样性分析显示文摘用 2对稻瘟病菌的两性能育菌株 (交配型 1.1和交配型 1.2 )测定了来自湖南烟溪病圃上的 4年 12 4个稻瘟病菌株的交配型 ,用微卫星分子标记分析其中 10 5个菌株的遗传多样性及其亲缘关系。12 4个菌株中 ,2 8个为交配型 1.1,39个为交配型 1.2 ,5 7个不育 ,分别占供试菌株的 2 2 .5 8%、31.4 5 %和 4 5 .97% ;在 0 .6 7相似性的基础上 ,7对微卫星引物扩增出的标记可将 10 5个菌株区分为 6个系谱群。 | 沈瑛 Julien FROUIN 何月秋 Claudia KAYE 肖放 Jean Loup NOTTEGHEM 刘二 Didier THARREAU | 2004 | 中国水稻科学2004，18，3： | 10 |
| 3 | Genomic Prediction of Arsenic Tolerance and Grain Yield in Rice: Contribution of Trait-Specific Markers and Multi-Environment Models显示文摘Many rice-growing areas are affected by high concentrations of arsenic(As).Rice varieties that prevent As uptake and/or accumulation can mitigate As threats to human health.Genomic selection is known to facilitate rapid selection of superior genotypes for complex traits.We explored the predictive ability(PA)of genomic prediction with single-environment models,accounting or not for trait-specific markers,multi-environment models,and multi-trait and multi-environment models,using the genotypic(1600K SNPs)and phenotypic(grain As content,grain yield and days to flowering)data of the Bengal and Assam Aus Panel.Under the base-line single-environment model,PA of up to 0.707 and 0.654 was obtained for grain yield and grain As content,respectively;the three prediction methods(Bayesian Lasso,genomic best linear unbiased prediction and reproducing kernel Hilbert spaces)were considered to perform similarly,and marker selection based on linkage disequilibrium allowed to reduce the number of SNP to 17K,without negative effect on PA of genomic predictions.Single-environment models giving distinct weight to trait-specific markers in the genomic relationship matrix outperformed the base-line models up to 32%.Multi-environment models,accounting for genotype×environment interactions,and multi-trait and multi-environment models outperformed the base-line models by up to 47%and 61%,respectively.Among the multi-trait and multi-environment models,the Bayesian multi-output regressor stacking function obtained the highest predictive ability(0.831 for grain As)with much higher efficiency for computing time.These findings pave the way for breeding for As-tolerance in the progenies of biparental crosses involving members of the Bengal and Assam Aus Panel.Genomic prediction can also be applied to breeding for other complex traits under multiple environments. | Nourollah AHMADI Tuong-Vi CAO Julien FROUIN Gareth J.NORTON Adam H.PRICE | 2021 | Rice science2021，28，3： | 3 |
| 4 | Estimating Photosynthetically Active Radiation(PAR) at the Earth's Surface from Satellite Observations显示文摘 | Frouin R Pinker R | 1995 | Remote Sensing of Environment1995，51，1： | 1 |
| 5 | Microstructural analysis of RPC(reactive powder concrete)显示文摘 | CHEYREZY M MARET V FROUIN L | | 0，，07： | 1 |
| 6 | Microstructural Analysis of RPC(Reactive Powder Concrete)显示文摘 | MARCEL Cheyrezy VINCENT Maret LAURENT Frouin | 1995 | Cement and Concrete Research1995，25，7： | 1 |
| 7 | Microstructural analysis of RPC 显示文摘 | Marcel Cbeyrezy Vincent Maret Laurent Frouin | 1995 | Cement and Concrete Research1995，25，7： | 1 |
| 8 | Microstructural analysis of RPC (reactive powder concrete)显示文摘 | Cheyrezy M Maret V Frouin L | 1995 | Cem Concr Res1995，25，7： | 1 |
| 9 | Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: A cardiovascular magnetic resonance study显示文摘 | Dogui A Kachenoura N Frouin F | 2011 | Journal of Cardiovascular Magnetic Resonance2011，13，1： | 1 |
| 10 | Estimating photosynthetically active ra diation (PAR) at the earth's surface from satellite observation 显示文摘 | Frouin R R T Pinker | 1995 | Remote Sens Environ1995，51，： | 1 |
| 11 | Correction of Partial Volume Effect for PET Striatal Imaging: Fast Implementation and Study of Robustness显示文摘 | Frouin V Comtat C Reilhac A | 2002 | J Nucl Med2002，43，： | 1 |
| 12 | Microstructural analysis of RPC(reactive powder concrete) 显示文摘 | CHEYREZY M MARET V FROUIN L | 1995 | Cement and Concrete Research1995，25，7： | 1 |
| 13 | Effects of temperature and salinity on haemocyte activities of the pacific oyster, Cras- sostrea gigas (Thunberg) 显示文摘 | Gagnaire B Frouin H Moreau K | 2006 | Fish Shellfish Immunology2006，20，4： | 1 |
| 14 | The human stress activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins显示文摘 | Miccoli L Frouin I Novac O | 2005 | Mol Cell Biol2005，25，9： | 1 |
| 15 | Microstructural analysis of RPC (Reactive Powder Concrete)显示文摘 | CHEYREZU M MARET V FROUIN L | 1995 | Cement and Concrete Research1995，25，7： | 1 |
| 16 | Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles显示文摘 | Poupon C Clark C A Frouin V | 2000 | NeuroImage2000，12，2： | 1 |
| 17 | Rice root genetic architecture: meta analysis from a drought QTL database显示文摘 | Courtois B Ahmadi N Khowaja F Price A H Rami J F Frouin J Hamelin C Ruiz M | 2009 | Rice2009，，2： | 1 |
| 18 | Effects of temperature and salinity on haemocyte activities of the pacific oyster,Crassostrea gigas(Thunberg)显示文摘 | Gagnaire B Frouin H Moreau K | 2006 | Fish and Shellfish Immunology2006，20，4： | 1 |
| 19 | Micro-structure analysis of reactive powder concrete 显示文摘 | Cheyrezy M Maret V Frouin L | 1995 | Cement and Concrete Research1995，25，7： | 1 |
| 20 | Reduction of skylight reflection effects in the above-water measurement of diffuse marine reflectance 显示文摘 | Fougnie B Frouin R Lecomte P | 1999 | Applied Optics1999，38，18： | 1 |
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