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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | 钾通道J亚家族成员5基因嵌合导致双侧肾上腺皮质增生进而引起的早期原发性醛固酮增多症显示文摘钾通道J亚家族成员5(potassium voltage-gated channel subfamily J member 5,KCNJ5)的体细胞变异最易导致原发性醛固酮增多症(primary aldosteronism,PA),有部分患者因KCNJ5钾通道基因的生殖细胞突变而患该病[家族性醛固酮增多症Ⅲ型(familial hyperaldosteronismⅢ,FH-Ⅲ)]。方法:1998年,美国国立卫生研究院临床中心发现一名11岁的白人男孩,患有早期严重高血压。 | Maria AG Suzuki M Berthon A Kamilaris C Demidowich A Lack J Zilbermint M Hannah-Shmouni F Faucz FR Stratakis CA 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 4 | Vitrectomy results in diabetic macular oedema w ithout evident vitreomacu-lar traction显示文摘 | La Heij EC Hendrikse F Kessels AG Derhaag PJ | 2001 | Graefes Arch Clin Exp Ophthalmol2001，239，4： | 1 |
| 5 | Non-Hodgkinp′s lymphoma in bone:pathologic and radiologic features with clinical correlates显示文摘 | Clayton F Butler JJ Ayala AG | 1987 | Cancer1987，60，10： | 1 |
| 6 | IgA nephropathy,the most common cause of glomerulonephritis,is linked to 6q22-23显示文摘 | Gharavi AG Yan Y Scolari F | | 0，，： | 1 |
| 7 | Hyperphagia,rage,and dementia accompan-ying a ventromedial hypothalamic neoplasm显示文摘 | Reeves AG Plum F | 1969 | Arch Neurol1969，20，6： | 1 |
| 8 | Effect of spi?ronolactone on diastolic function and exercise capacity in pati?ents with heart failure with preserved ejection fraction: the Aldo- DHF randomized controlled trial显示文摘 | Edelmann F Wachter R Schmidt AG et aJ | 2013 | JAMA2013，309，8： | 1 |
| 9 | Creatine kinas-BB in the cerebrospinal fluid as a marker of CNS metastasis and leptomeningeal carcino-matosis in patients with breast cancer显示文摘 | Bach F Bach FW Pedersen AG | 1989 | Eur J Cancer Clin Oncol1989，25，2： | 1 |
| 10 | A 1-to 12-year clinical evaluation of 106 endosseous implants supporting fixed and removable prostheses 显示文摘 | Aykent F Inan O Ozyesil AG | 2007 | Int J Periodontics Restorative Dent2007，27，4： | 1 |
| 11 | Emer- ging role of advanced glyeation-end products (AGEs) in the pathobiology of eye diseases 显示文摘 | Kandarakis SA Piperi C Topouzis F Papavassiliou AG | 2014 | Prog Retin Eye Res2014，42，1： | 1 |
| 12 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 13 | Improve System Reformer Performance 显示文摘 | Hohmann F W Lurgi AG Frankfurt Germany | 1996 | Hydrocarbon Processing1996，75，3： | 1 |
| 14 | Regional differences in semen quality in Europe显示文摘 | Jorgensen N Andersen AG Eustache F | 2001 | Hum Reprod2001，16，5： | 1 |
| 15 | Fouling in reverseosmosis:detection by non-invasive techniques显示文摘 | Chong T H Wong F S Fane AG | 2007 | De-salination2007，204，： | 1 |
| 16 | Preclinical analysis of the analinoquinazoline AG1478,a specific small molecule inhibitor of EGF receptor tyrosine kinase显示文摘 | Ellis AG Doherty MM Walker F | 2006 | Biochem Pharmacol2006，71，10： | 1 |
| 17 | Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node negative non-small cell lung cancer? 显示文摘 | Nicholson AG Graham AN Pezzella F | 1997 | Lung Cancer1997，18，3： | 1 |
| 18 | Porphyromonas gingivalis muty is involved in the repair of oxidative stress-induced DNA mispairing 显示文摘 | Robles AG Reid K Roy F | 2011 | Mol Oral Microbiol2011，26，3： | 1 |
| 19 | Adenomas of the large intestine after cholecystectomy显示文摘 | MANNES AG WEINZIERL M STELLAARD F | | 0，，08： | 1 |
| 20 | Am allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with the HLA Al,B8,and DR3 alleies显示文摘 | De Vrkes N Plcklt F | 1993 | Exp Med1993，177，： | 1 |
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