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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 3 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 4 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 5 | The supraorbital keybole approach to supratentorial aneurysms: concept and technique 显示文摘 | Van Lindert E Perneczky A Fries G | 1998 | Surg Neurol1998，49，5： | 2 |
| 6 | Phenotypic switching and its implications for the pathogenesis of cryptococcus neoformans 显示文摘 | Jain N Guerrero A Fries BC | 2006 | FEMS Yeast Res2006，6，4： | 1 |
| 7 | A survey of discrete reliability-growth models显示文摘 | Fries A Sen A | 1996 | IEEE Transactions on Reliability1996，45，4： | 1 |
| 8 | Minimum aberration 2k-p designs显示文摘 | Fries A Hunter W G | 1980 | Technometrics1980，22，： | 1 |
| 9 | Chromosomal localization of the major histocompatibility complex of the horse ( ELA ) by in situhybridization显示文摘 | Ansari H A Hediger R Fries R | 1988 | Immunogenetics1988，28，： | 1 |
| 10 | Vitamin C degradation in plant cells via enzymatic hydrolysis of 4-0 oxalyl-L threonate显示文摘 | GREEN M A FRY S C | 2005 | Nature2005，433，： | 1 |
| 11 | The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE)显示文摘 | TAN E M COHEN A S FRIES J F | 1982 | Arthritis Rheum1982，25，11： | 1 |
| 12 | The 1982 revised criteria for the classification of systemic lupus erythematosus, (SLE)显示文摘 | Tam E M Cohen A S Fries J F | 1982 | Arthritis Rheum1982，25，： | 1 |
| 13 | Development of a quan titative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assay s显示文摘 | Pas sd Fries E De Man R A | 2000 | Clin Microbiol2000，39，8： | 1 |
| 14 | Accounting for Environment Effects and Statisticalnoise in Data Envelopment Analysis显示文摘 | Fried H O Lovell C A K Schmidt S S Yaisawarng S | 2002 | Journal of Productivi- ty Analysis2002，17，12： | 1 |
| 15 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 16 | Executive Compensation as an Agency Problem显示文摘 | Bebchuk L A Fried J M | 2003 | The Journal of Economics Per- spectives2003，17，3： | 1 |
| 17 | Aberrant splicing of estrogen receptor,HER2and CD44 genes in breast cancer显示文摘 | Kazushi Inoue Elizabeth A Fry | 2015 | Genet Epigenet2015，7，： | 1 |
| 18 | Assessment of the gene content of the chromosomal regions flanking bovine DGAT1显示文摘 | WINTER A ALZINGER A FRIES R | 2004 | Genomics2004，83，1： | 1 |
| 19 | Executive Compensation at Fannie Mae: A Case Study of Perverse Incentives, Nonperformance Pay, and Camouflage 显示文摘 | Lucian A Bebchuk Jesse M Fried | 2005 | Journal of Corporation Law2005，30，： | 1 |
| 20 | The supraorbital keyhole approach to supratentonal aneurysms: concept and technique显示文摘 | LINDERT E PERNECZKY A FRIES G | 1998 | Sttrg Neurol1998，49，5： | 1 |
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