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| 1 | The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy显示文摘The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs,thereby contributing to several aspects of adaptive immunity and immune tolerance.In the present study,we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis(CIA).By using a novel anti-human CCR7 antibody and humanized CCR7 mice,we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis(RA).Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II(CII).Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers.Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression,respectively.Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA. | Georgios L.Moschovakis Anja Bubke Michaela Friedrichsen Jasmin Ristenpart Jaap Willem Back Christine S.Falk Elisabeth Kremmer Reinhold Forster | 2019 | Cellular & Molecular Immunology2019，16，10： | 3 |
| 2 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 3 | Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways 显示文摘 | FRIEDRICHSEN B N NEUBAUER N LEE Y C | 2006 | J Endocrinol2006，188，3： | 1 |
| 4 | Limonoidsfrom Khaya senegalensis显示文摘 | Khalid SA Friedrichsen GM Kharazmi A | 1998 | Phytochemistry1998，49，6： | 1 |
| 5 | Reg- ulatory mechanisms and impact of circulating and tissue expression 显示文摘 | Ribel-Madsen R Friedrichsen M Vaag A | 2009 | Diabetes2009，58，1： | 1 |
| 6 | Signal trans-ducer and activator of transcription 5 activation is sufficient todriver transcription! induction of cyclinDl gene and proliferationof rat pancreatic beta-cells显示文摘 | Friedrichsen B N Richter H E Hansen J A | 2001 | Mol Endocrinol2001，17，5： | 1 |
| 7 | A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development显示文摘 | Yin Y H Cheong H Friedrichsen D | 2002 | Proc Natl Acad Sci U S A2002，99，10： | 1 |
| 8 | Brassinosteroidinsensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase显示文摘 | FRIEDRICHSEN D M JOAZEIRO C A P LI J M | 2000 | Plant Physiology2000，123，4： | 1 |
| 9 | Three redundant brassinosteroid early response genes encode putative bHLH transcription factors required for normal growth 显示文摘 | Friedrichsen D M Nemhauser J Muramitsu T | 2002 | Genetics2002，162，： | 1 |
| 10 | Sterically encumbered functional groups: An investigation of endo versus exo phosphoryl complexation using ^1 H and ^31P NMR显示文摘 | FRIEDRICHSEN B P POWELL D R WHITLOCK H W | 1990 | Journal of the American Chemical Society1990，112，24： | 1 |
| 11 | Pharmacokinetic comparison of oral and intravenous etoposide in patients treated with the CHOEP - regimen for malignant lymphomas 显示文摘 | Kroschinsky FP Friedrichsen K Mueller J | 2008 | Cancer Chemother Pharmacol2008，61，5： | 1 |
| 12 | Expression,biosynthesis and release of preadipocyte factor-1/delta-like protein/fetal antigen-1 in pancreatic beta-cells:possible physiological implications显示文摘 | Friedrichsen BN Carlsson C Moldrup A | 2003 | Endocrind2003，176，2： | 1 |
| 13 | Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signaling pathways显示文摘 | Friedrichsen BN Neubauer N Lee YC | 2006 | J Endocrinol2006，188，3： | 1 |
| 14 | Adaptation of solitary intestinal lymphoid tissue in response to microblota and chemokine receptor CCR7 signaling 显示文摘 | PABST O HERBRAND H FRIEDRICHSEN M | 2006 | J Immunol2006，177，10： | 1 |
| 15 | Wnt signaling in estrogen-induced lactotroph proliferation显示文摘 | Giles A Madec F Friedrichsen S | 2011 | J Cell Sci2011，124，： | 1 |
| 16 | Treatment of idiopathicmacular holes by induced posterior vitreous detachment显示文摘 | Chan CK Wessels IF Friedrichsen EJ | 1995 | Ophthalmology1995，102，5： | 1 |
| 17 | Spatial organization of intestinal microbiota in the mouse ascending colon显示文摘 | NAVA G M FRIEDRICHSEN H J STAPPENBECK TS | 2011 | ISME J2011，5，4： | 1 |
| 18 | Concerns about Losing Control When Breaking Bad News to Terminally Ill Patients with Cancer: Physicians' Perspective显示文摘 | Friedrichsen M Milberg A | 2006 | J Palliat Med2006，9，3： | 1 |
| 19 | Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity显示文摘 | FRIEDRICHSEN M MORTENSEN B PEHMOLLER C | 2013 | Mol Cell Endocrinol2013，366，2： | 1 |
| 20 | Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity显示文摘 | FRIEDRICHSEN M MORTENSEN B PEHMOLLER C | 2013 | Mol Cell Endocrinol2013，366，2： | 1 |
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