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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | 磁共振成像在诊断颞下颌关节盘移位中的应用显示文摘28例临床诊断为颞下颌关节盘移位的患者和2例作为对照的无症状自愿受检者共47侧关节接受了磁共振成像的检查。结果提示,磁共振成像可以提供非常清晰的关节盘形状、位置和精确的盘─突关系的图象。作者评价了磁共振成像的准确性,讨论了磁共振成像的优、缺点,另外还介绍了磁共振成像的简单原理。 | 林野 Pape HD Friedrich R Fischboch R | 1994 | 华西口腔医学杂志1994，12，1： | 3 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | Present state of the comparison between radiometric scales based on three primary standards显示文摘 | STOCK M FISCHER J FRIEDRICH R | 1993 | Metrologia1993，30，： | 2 |
| 5 | A multiple scattering solution for the effective permittivity of a sphere mixture显示文摘 | Chew W C Friedrich J A Geiger R | 1990 | IEEE Trans Geosci Remote Sensing1990，28，2： | 1 |
| 6 | In situ removal of dissolved phosphorus in irrigation drainage water by planted floats:Preliminary results from growth chamber trail显示文摘 | Li W Friedrich R | 2002 | Agric Ecosyst Environ2002，90，1： | 1 |
| 7 | Overexpression of p161NK4a as a specific marker for dysplastic and neoplastic epithelial cdlls of the cervic uteri 显示文摘 | KLAES R FRIEDRICH T SPIKOVSKY D | 2001 | INT J Cancer2001，92，2： | 1 |
| 8 | p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia显示文摘 | Klaes R Benner A Friedrich T | 2002 | Am J Surg Pathol2002，26，11： | 1 |
| 9 | Detecting active methanogenic populations on rice roots using stable isotope probing 显示文摘 | Lu Y Lueders T Friedrich M W Conrad R | 2005 | Environ Microbiol2005，7，3： | 1 |
| 10 | Influence of water up- take on inter-laminar fracture properties of carbon fibre-reinforced polymer composites 显示文摘 | SELZER R FRIEDRICH H K | 1995 | Journal of Materials Science1995，30，： | 1 |
| 11 | Surgical anatomy of the larynx 显示文摘 | FRIEDRICH G LICHTENEGGER R | 1997 | J Voice1997，11，3： | 1 |
| 12 | Overexpression of P16 as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri显示文摘 | Klaes R Friedrich T Spitkovsky D | | 0，，2： | 1 |
| 13 | P16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia显示文摘 | Klaes R Benner A Friedrich T | 2002 | Am J Surg Pathol2002，26，11： | 1 |
| 14 | In situ removal of dissolved phosphorus in irrigation drainage water by planted floats: preliminary results from gowth chamber trial显示文摘 | Li W Friedrich R | 2002 | Agric Ecosyst Environ2002，90，1： | 1 |
| 15 | Sliding wear performance of polymer composites under abrasive and water lubricated conditions for pump applications显示文摘 | Prehn R Haupert F Friedrich K | 2005 | Wear2005，259，16： | 1 |
| 16 | Branched fluorinated amphiphiles based on carbohydrates 显示文摘 | SCHUSTER T SCHELLENBERGER S FRIEDRICH R | 2013 | J Fluorine Chem2013，154，： | 1 |
| 17 | Primitive neuroectodermal tumor (PNET)in the differential diagnosis of malignant kidney tumors 显示文摘 | Vorreuther R Poremba C | 2002 | Pathol Res Pract2002，198，8： | 1 |
| 18 | In situ removal of dissolved phosphorus in irrigation drainage water by planted floats:preliminary results from growth chamber experiment 显示文摘 | LI W FRIEDRICH R | 2002 | Agriculture Ecosystems and Environment2002，90，1： | 1 |
| 19 | Primitive neuroectodermal tumor (PNET) in the differential diagnosis of malignant kidney tumors显示文摘 | Friedrichs N Vorreuther R Poremba C | 2002 | Pathol Res Pract2002，198，8： | 1 |
| 20 | Lack of RUNX3 regulation in human gastric cancer显示文摘 | Friedrich MJ Rad R | 2006 | J Pathol2006，210，2： | 1 |
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