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| 1 | Liver fibrogenesis and the role of hepatic stellate cells:new insights and prospects for therapy显示文摘 | Li D Friedman SL | | 0，，： | 5 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Fetal cardiac function assessed by Doppler myocardial performance index (Tei index)显示文摘 | Friedman D Buyon J Kim M | 2003 | Ultrasound Obstet Gynecol2003，21，1： | 2 |
| 4 | Bayesian network classifiers显示文摘 | FRIEDMAN N GEIGER D GOLDSZMIDT M | 1997 | Machine Learning1997，29，3： | 1 |
| 5 | Evolutionary games in economics显示文摘 | Friedman D | 1991 | Econometrica1991，59，3： | 1 |
| 6 | Acute stress facilitates long-lasting changes in chrolinergic gene expression显示文摘 | Kaufer D Friedman A Seidman S | 1998 | Nature1998，393，6683： | 1 |
| 7 | Inhibition of the HIV-1 Protease by Fullerene Derivatives: Model Building Studies and Experimental Verification显示文摘 | Friedman S H DeCamp D L Sijbesma R P etc | 1993 | J Am Chem Soc1993，115，： | 1 |
| 8 | Generalized peisach model of hysteresis (Invited) 显示文摘 | Mayergoyz I D Friedman G | 1988 | IEEE Trans on Magnetics1988，24，1： | 1 |
| 9 | Rapid regulation of depression - related behaviours by control of midbrain dopamine neurons显示文摘 | Chaudhury D Walsh JJ Friedman AK | 2013 | Nature2013，493，7433： | 1 |
| 10 | The anticariogenic effect of amine fluorides on streptococcus sobrinus and glucosyhransferase in biofilms 显示文摘 | Sharti S Friedman M Steinberg D | 2000 | Caries Res2000，34，3： | 1 |
| 11 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 12 | Comprehensive genomic characterization defines human glioblastoma genes and core pathways显示文摘 | Mclendon R Friedman A Bigner D | 2008 | Nature2008，455，7216： | 1 |
| 13 | Pneumonia with serological evidence of acute infection with the Chlamydia-like microorganism 'Z'显示文摘 | Kahane S Friedman MG | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 14 | An ultra-compact differentially tuned 6-GHz CMOS LC-VCO with dynamic common-mode feedback 显示文摘 | SOLTANIAN B FRIEDMAN D RHEE W | 2007 | IEEE J of Solid-State Circuits2007，42，8： | 1 |
| 15 | On economic applications of evolutionary game theory 显示文摘 | Friedman D | 1998 | Journal of Evolutionary Economies1998，8，1： | 1 |
| 16 | Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry显示文摘 | Friedman D B Hill S Keller J W | 2004 | Proteomics2004，4，3： | 1 |
| 17 | The establishment of an academic nursing faculty: action research in Israel显示文摘 | Arieli D Friedman V J Hirschfeld M J | 2009 | Int Nurs Rev2009，56，3： | 1 |
| 18 | Evolutionary Game in Economics 显示文摘 | Friedman D | 1991 | Econometrica1991，59，3： | 1 |
| 19 | Liver fibrogenesis and the role of hepatic stellate cells:new imights andprospocts for therapy显示文摘 | Friedman SL | 1999 | J Gastroenterol Hepatol1999，14，7： | 1 |
| 20 | Evolutionary games in economics显示文摘 | Friedman D | 1991 | Econometrical1991，59，3： | 1 |
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