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| 1 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 2 | Carbons as supports for industrial precious metal catalysts 显示文摘 | Auer E Freund A Pietsch J | 1998 | Applied Catalysis A : General1998，173，2： | 1 |
| 3 | Connective tissue polarity: optical second harmonic microscopy, crossed-beam summation, and small-angle scattering in rat-tail tendon显示文摘 | Freund I Deutsch M Sprecher A | 1986 | Biophys1986，50，： | 1 |
| 4 | Tracking changes following spinal cord injury:insights from neuroimaging显示文摘 | Freund P Curt A Friston K Thompson A | 2013 | Neuroscientist2013，19，2： | 1 |
| 5 | Requirement of nu- clear factor-NF-~B in angiotensin II - and isoproterenol-induced cardiac hypertrophy in vivo 显示文摘 | Freund C Schmidt-Ullrich R Baurand A | 2005 | Circulation2005，111，18： | 1 |
| 6 | IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells显示文摘 | Freund A Chauveau C Brouillet JP | 2003 | Oncogene2003，22，8： | 1 |
| 7 | Bone bruise of the knee:histology and cryosections in 5 cases显示文摘 | Rangger C Kathrein A Freund MC | 1998 | Acta Orthop Scand1998，69，3： | 1 |
| 8 | Principles of Phar- macoeconomic Analysis of Drug Therapy 显示文摘 | Freund D A Dittus R S | 1992 | Pharma- coeconomics1992，1，1： | 1 |
| 9 | Acetylene and Ethylene Hydrogenation on Alumina Supported Pd-Ag Model Catalysts显示文摘 | Khan N A Shaikhutdinov S Freund H J | 2006 | Catal Lett2006，108，34： | 1 |
| 10 | High resolution solid state 13C2NMR studies of the crosslink structure in accele2rated sulfur vulcanizated natural rubber显示文摘 | Gronski W Hasachiri! A Freund B | 1991 | Kautsch und Gummi Kun- ststorff1991，44，2： | 1 |
| 11 | Distribution of chloride channel-2-immunoreactive neuronal and astrcytic processes in the hippocampus显示文摘 | Sik A Smith R L Freund T F | 2000 | Neuro Science2000，101，： | 1 |
| 12 | Natural genetic variation of freez- ing tolerance in Arabidopsis显示文摘 | Hannah M A Wiese D Freund S | 2006 | Plant Physiol2006，142，： | 1 |
| 13 | Highly Efficient Enzymatic Synthesis of 2 - Monoacylglycerides and Structured Lipids and their Production on a Technical Scale 显示文摘 | Pfeffer J Freund A Bel - Rhlid R | 2007 | Lipids2007，42，10： | 1 |
| 14 | Retrograde intubation with a modified Eschman stylet显示文摘 | Rooke A Schwid H | 1988 | Anesth Analg1988，67，： | 1 |
| 15 | Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53显示文摘 | FRIEDLER A FREUND S | 2002 | Proc Natl Acad Sci USA2002，99，10： | 1 |
| 16 | The transmembrane protein-tyrosine phosphatase CD45 is associated withdecreased insulin receptor signaling 显示文摘 | Kulas D T Freund G G Mooney R A | 1996 | J Biol Chem1996，271，： | 1 |
| 17 | CP-Violation in neuyrino oscillations显示文摘 | Freund M Lindner M Roneanino A | 1999 | Hep-ph/9903308101999，，： | 1 |
| 18 | Natural genetic variation of t'reezing tolerance in Arabidopsis显示文摘 | HANNAH M A WIESE D FREUND S | 2006 | Plant Physiology2006，142，1： | 1 |
| 19 | Carbons as supports for industrial precious metal catalysts显示文摘 | AUER E FREUND A PIETSCH J | 1998 | Appl Catal A1998，173，2： | 1 |
| 20 | Inflammatory networks during cellular senescence: causes and consequences显示文摘 | Freund A Orjalo AV Desprez PY | 2010 | Trends Mol Med2010，16，5： | 1 |
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