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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 3 | Morfologia do tubo digest6rio da tartaruga verde (Chelonia mydas) 显示文摘 | MAGALHAES M S FREITAS M D L SILVAE N B D | 2010 | Pesquisa Veterindria Brasileira2010，30，8： | 1 |
| 4 | Association of systemic inflammatory activity with coronary and carotid atherosclerosis in the very elderly显示文摘 | Freitas W M Quaglia L A Santos S N etal | 2011 | Atherosclerosis2011，2，1： | 1 |
| 5 | Montreal Cognitive Assessment(MoCA):normative study for the portuguese population显示文摘 | Freitas S Simes MR Alves L | 2011 | Clin Exp Neuropsychol2011，33，9： | 1 |
| 6 | Limbal relaxing incisions to correct corneal astigmatism during phacoemulsification显示文摘 | Carvalho M J Suzuki S Freitas L L | 2007 | J Refract Surg2007，23，5： | 1 |
| 7 | The origin of green emission in polyfluorene-based conjugated polymers: On-chain defect fluoscence显示文摘 | Romaner L Pogantsch A de Freitas P S | 2003 | Adv Func Mater2003，13，8： | 1 |
| 8 | Proteinaceous protease inhibitors: structural features and multiple functional faces显示文摘 | JOANITI'I G A FREITAS S M SILVA L P | 2006 | Current Enzyme Inhibition2006，2，3： | 1 |
| 9 | Decomposing the decoupling of CO2 emissions and economic growth in brazil显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Economics2011，70，8： | 1 |
| 10 | Montreal cognitive assessment(MoCA):validation study for vascular dementia显示文摘 | Freitas S Simoes MR Alves L | 2012 | J Int Neuropsychol Soc2012，18，6： | 1 |
| 11 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | MELO M R S FEITOSA J P A FREITAS A L P | 2002 | Carbohyd Polym2002，49，： | 1 |
| 12 | Decomposing the Decoupling of CO2 Emissions and Economic Growth in Brazil 显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Eco- nomics2011，70，8： | 1 |
| 13 | Phylogeny of the Nymphalidae(Lepidoptera)显示文摘 | FREITAS A V L BROWN K S | 2004 | Systematic Biology2004，53，3： | 1 |
| 14 | Application of Wada's group contribution method to the prediction of the speed of sound ofbiodiesel 显示文摘 | FREITAS S V D CUNHA D L REIS R A | 2013 | Energy Fuels2013，338，： | 1 |
| 15 | Structural contributions for thermostability of a new endo - 1,4 -β- xylanase from the fungus humicola grisea 显示文摘 | S M De Freitas W L Treptow F P De Faria | 2003 | Internet Electronic Journal of Molecular Design2003，，2： | 1 |
| 16 | Measurement and prediction of speeds of sound of fatty acid ethyl esters and ethylic biodiesels 显示文摘 | FREITAS S V D SANTOS A MOITA M L C J | 2013 | Fuel2013，108，： | 1 |
| 17 | p - q Theory power components calculations 显示文摘 | Afonso J L Freitas M J S Martins J S | 2003 | 1EEE International Symposium on Industrial Electronics2003，1，6： | 1 |
| 18 | Interactions of an urban heat island and sea-breeze circulations during winter over the metropolitan area of Sao Paulo, Brazil 显示文摘 | Freitas E D Rozoff C M Cotton W PDias P L S | 2007 | Bound-Layer Meteor2007，122，1： | 1 |
| 19 | Analysis of a Soft-switched PFC Boost Converter Using Analog and Digital Control Circuits显示文摘 | Barreto L H S C Sebastiao M G de Freitas etal | 2005 | Industrial Electronics IEEE Transactions2005，52，1： | 1 |
| 20 | Measurement and prediction of the speed of sound of biodiesel fuels 显示文摘 | FREITAS S V D PPAREDES M L L DARIDON J L | 2013 | Fuel2013，103，： | 1 |
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