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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Decomposing the decoupling of CO2 emissions and economic growth in brazil显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Economics2011，70，8： | 1 |
| 3 | Enterobaeterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates 显示文摘 | Sampaio J L Viana Niero C de Freitas D | 2006 | Diagnostic Microbiology and Infectious Disease2006，55，2： | 1 |
| 4 | Identification of material properties of composite plate specimens显示文摘 | Mota Soares C M Moreira de Freita M Araujo A L | 1993 | Composite Structures1993，25，： | 1 |
| 5 | Decomposing the Decoupling of CO2 Emissions and Economic Growth in Brazil 显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Eco- nomics2011，70，8： | 1 |
| 6 | A Boost PWMSoft-single-switched Converter with Low Voltage and Current Stresses 显示文摘 | Lambert J A Vieira J B de Freitas L C | 1998 | IEEE Trans on Power Electronics1998，13，1： | 1 |
| 7 | Analysis of a Soft-switched PFC Boost Converter Using Analog and Digital Control Circuits显示文摘 | Barreto L H S C Sebastiao M G de Freitas etal | 2005 | Industrial Electronics IEEE Transactions2005，52，1： | 1 |
| 8 | Effects of feeding organic acids for piglets from 21 to 49 days 显示文摘 | De Freitas L S Lopes D C De Freitas A F et a/ | 2006 | Brazil- ian Journal of Animal Science2006，35，： | 1 |
| 9 | Decomposing the decoupling of CO2emissions and economic growth in Brazil显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Economics2011，70，8： | 1 |
| 10 | Decomposing the decoupling of CO2 emissions and economic growth in Brazil显示文摘 | DE FREITAS L C KANEKO S | | 0，，08： | 1 |
| 11 | The influence of chemical composition and microstructure of API linepipe steels on hydrogen induced cracking and sulfide stress corrosion cracking显示文摘 | CARNEIRO R A RATNAPULI R C DE FREITAS C L V | 2003 | Materials Science and Engineering:A2003，357，1： | 1 |
| 12 | Identification of domoic acid,a neuroexcitatory amino acid,in toxic mussels from eastern Prince Edward Island显示文摘 | Wright J L C Boyd R K De Freitas A S W | 1989 | Canadian Journal of Chemistry1989，67，： | 1 |
| 13 | Activation of the UNCSB receptor by netrin-1 inhibits sprouting angiogenesis显示文摘 | Larrivee B Freitas C Trombe M Lv X De Lafarge B Yuan L | 2007 | Genes Dev2007，21，： | 1 |
| 14 | Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island 显示文摘 | Wright J L C Boyd R K De Freitas A S W | 1989 | Can J Chem1989，67，： | 1 |
| 15 | Decomposing the decou- pling of CO2 emissions and economic growth in Brazil显示文摘 | DE FREITAS L C KANEKO S | 2011 | Ecological Economics2011，70，8： | 1 |
| 16 | Identification of material properties of composite plate specimens显示文摘 | Mota Soares C M Moreira de Freitas M and Araujo A L | 1993 | Composite Structures1993，25，： | 1 |
| 17 | Performance evaluation of a novel hybrid multipulse rectifier for utility interface of power electronic converters显示文摘 | de FREITAS L C G SIMOES M G CANESIN C A | 2007 | IEEE Trans on Industrial Electronics2007，54，6： | 1 |
| 18 | Chemical neuroanatomical and psychopharmacological evidence thatκreceptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour显示文摘 | da Silva J A de Freitas R L Eichenberger G C | 2013 | Eur J Pharmacol2013，698，13： | 1 |
| 19 | Programmable PFC based hybrid multipulse power rectifier for ultra clean power application显示文摘 | de FREITAS L C G SIMOES M G CANESIN C' A | 2006 | IEEE Trans on Power Electronics2006，21，4： | 1 |
| 20 | Decomposing the decoupling of CO2 emissions and economic growth in Brazil显示文摘 | De Freitas L C Kaneko S | 2011 | Ecolog- ical Economics2011，70，： | 1 |
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