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| 1 | Choledocholithiasis: Evolving standards for diagnosis and management显示文摘胆石病,导致外科的干预的最普通的医药条件之一,在美国影响成年人口的约 10 % 。胆总管石病与胆囊石头在大约病人的 10%-20% 发展,文学建议至少经历胆囊炎的病人的 3%-10% 将有胆总管(CBD ) 石头。CBD 石头可以外科手术前地, intraoperatively 或手术后地被发现多重形式为包括实验室测试,超声,计算断层摄影术扫描(CT ) ,和磁性的回声 cholangiopancreatography (MRCP ) 为胆总管石病估计病人是可得到的。Intraoperative 胆管造影术能习惯性地或有选择地在胆囊炎期间被使用诊断 CBD 石头。为 CBD 石头的最普通的干预是 ERCP。另外的通常使用的干预包括 intraoperative 胆汁管探索,任何一个 laparoscopic 或 open。经皮, transhepatic 石头移动胆汁的清理的另外的新奇技术被设计了。与这些技术灵巧的设备和有技能的专业人员的可获得性在机构之中变化。预定干预被临床的状况经常支配。 | Marilee L Freitas Robert L Bell Andrew J Duffy | 2006 | World Journal of Gastroenterology2006，12，20： | 30 |
| 2 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 3 | 二维导流管喷动床的流动特征显示文摘带导流管的二维喷动床(2-DSBDP)是传统喷动床的改进型式,矩形床内设置的与床同厚的垂直导流管可以控制固体颗粒的循环速率, 同时使下行区中的气固移动床维持平推流. 本文实验测定了不同表观气速、床层高度、固体颗粒与气体入口尺寸时, 二维导流管喷动床的床压降及相应的空隙率,藉以阐述2-DSBDP的流动特征. | 罗保林 Freitas L A P Lim C J Grace J R | 2000 | 化工冶金2000，21，4： | 5 |
| 4 | Effect of high hydrostatic pressure on the color and texture parameters of refrigerated Caiman ( Caiman crocodilus yacare ) tail meat显示文摘 | A.C.V.C.S. Canto B.R.C.C. Lima A.G. Cruz C.A. Lázaro D.G.C. Freitas Jose A.F. Faria R. Torrezan M.Q. Freitas T.P.J. Silva | 2012 | Meat Science2012，，3： | 2 |
| 5 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 6 | Voidage and particle velocity profiles in a spout-fluid bed 显示文摘 | Pianarosa D L Freitas L Lim C J | 2000 | The Canadian Journal of Chemical Engineering2000，78，2： | 2 |
| 7 | Characterization of protein hydrolysates prepared for enteral nutrition 显示文摘 | Freitas O Padovan G J Vilela L | 1993 | Agric Food Chem1993，41，： | 1 |
| 8 | Small-disturbance voltage stability of distribution systems with induction generators显示文摘 | FREITAS W DASILVA L C P MORELATO A | 2005 | IEEE Transactions on Power System2005，20，3： | 1 |
| 9 | Decomposing the decoupling of CO2 emissions and economic growth in Brazi显示文摘 | Freitas L C | 2011 | Ecological Economics2011，，6： | 1 |
| 10 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 11 | Small- disturbance voltage stability of distribution systems with induction generators显示文摘 | Freitas ~ da Silva L C P Morelato A | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 12 | Adsorption of Cu(II), Cd(II), and Pb(II)from aqueous single metal solutions by cellulose and mercerized cellulose chemically modified with succinic anhydride显示文摘 | GURGEL L V A JNIOR O K DE FREITAS GIL R P | 2008 | Bioresource Technology2008，99，8： | 1 |
| 13 | Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer显示文摘 | LIMA R A FREITAS E Q DIAS F L | 2006 | Head Neck2006，28，： | 1 |
| 14 | Ultrastructure, morphology and sporogenesis of Pasteuria penetrans显示文摘 | CHEN Z X DICKSON D W FREITAS L G | 1997 | Phytopathology1997，87，： | 1 |
| 15 | Developing emotional in- telligence ability in oncology nurses:a clinical rounds ap- proach显示文摘 | Codier E Freitas B Muneno L | 2013 | Oncol Nurs Forum2013，40，1： | 1 |
| 16 | Morfologia do tubo digest6rio da tartaruga verde (Chelonia mydas) 显示文摘 | MAGALHAES M S FREITAS M D L SILVAE N B D | 2010 | Pesquisa Veterindria Brasileira2010，30，8： | 1 |
| 17 | Modification of the surface chemistry of activated carbons显示文摘 | Figueiredo J L Pereira M F Freitas M M | 1999 | Carbon1999，37，： | 1 |
| 18 | Prognostic value of GRACE scores versus TIMI score in acute coronary syndromes显示文摘 | Correia L Freitas R Bitteneourt A | 2010 | Arq Bras Cardio12010，94，5： | 1 |
| 19 | Cushing's syndrome in pregnan- cy: an overview 显示文摘 | Vilar L Freitas MC Lima LHC | 2007 | Arg Bras Endocrinol Metab2007，51，8： | 1 |
| 20 | Prediction of drug dissolution profiles from tablets using NIR diffuse reflectance spectroscopy:A rapid and nondestructive method显示文摘 | Freitas M P Sabadin A Silva L M | 2005 | Journal of Pharmaceutical and Biomedical Analysis2005，39，12： | 1 |
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