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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Data mining with an ant colony optimization algorithm显示文摘 | Parpinelli R S Lopes H S Freitas A A | 2002 | IEEE Trans Evolutionary Compute2002，6，4： | 1 |
| 3 | Genetic diversity of the macaronesian leafy liverwort porella canariensis inferred from rapd markers显示文摘 | Freitas H Brehm A | 2001 | Heredity2001，92，： | 1 |
| 4 | Expression, purification and kinetic characterization of His-tagged glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi 显示文摘 | Cheleski J Freitas R F Wiggers H J | 2011 | Protein Expr Purif2011，76，2： | 1 |
| 5 | Sequential Monte Carlo methods to train neural network models 显示文摘 | De FREITAS J F G NIRANJAN M GEE A H | 2000 | Neural Computation2000，12，4： | 1 |
| 6 | A model for extremely heterogeneous clutter显示文摘 | FRERY A C MULLER H FREITAS C C | 1997 | IEEE Transactions on Geoscience and Remote Sensing1997，35，3： | 1 |
| 7 | Polymerization of ethylene: some aspects of metallocene cata- lyst stabilization under homogeneous and heterogeneous reac- tion conditions显示文摘 | de Freitas A J D dos Santos J H Z Meneghetti S M P | 2011 | J Appl Poiym Sci2011，119，5： | 1 |
| 8 | Influence of metal resist- ant-plant growth-promoting bacteria on the growth of Ricinus communis in soil contaminated with heavy metals 显示文摘 | Rajkumar M Freitas H | 2008 | CbemosDhere2008，7，5： | 1 |
| 9 | The polarimetrie G distribution for SAR data analysis 显示文摘 | Freitas C C Frery A C Correia A H | 2005 | Environmetries2005，16，1： | 1 |
| 10 | Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase 显示文摘 | Freitas C Muller R H | 1999 | EurJPharm Biopharm1999，47，2： | 1 |
| 11 | Perspectives of plantassociatedmicrobes in heavy metal phytoremediation 显示文摘 | Rajkumar M Sandhya S Prasad MNV Freitas H | 2012 | BiotechnolAdv2012，30，6： | 1 |
| 12 | Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance 显示文摘 | Freitas S Moore DH Michael H | 2003 | Clin Cancer Res2003，9，13： | 1 |
| 13 | Biotechnological applications of serpentine soil bacteria for phytoremediation of tracemetals显示文摘 | Rajkumar M Vara Prasad M N Freitas H | 2009 | Crit Rev Biotechno2009，29，： | 1 |
| 14 | Complement activation in Brazilian patients with preeclampsia 显示文摘 | Messias R I J Aleixo V Freitas H | 2000 | J Investig Allergol Clin Immunol2000，10，4： | 1 |
| 15 | Biotechnological applications of serpentine soil bacteria for phytoremediation of trace metals 显示文摘 | Rajkumar M Prasad M N V Freitas H | 2009 | Critical Reviews in Biotechnology2009，29，2： | 1 |
| 16 | Sequential Monte Carlo Methods to Train Neural Network Models显示文摘 | De Freitas J F G Niranjan M A Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 17 | Effects of inoculation of plant-growth promoting bacteria on Niuptake by Indian mustard显示文摘 | Rajkumar M Freitas H | 2008 | Bioresour Technol2008，99，： | 1 |
| 18 | Sequential Monte Carlo Methods to Train Neural Net- work Models显示文摘 | de Freitas J F G Niranjan M Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 19 | Flow-through ultrasonic emulsification combined with static micromixing for aseptic 显示文摘 | Freitas S Rudolf B Merkle H P | 2008 | Eur J Pharm Biopharm2008，61，3： | 1 |
| 20 | Removal of toxic metals from solution by leaf, stem and root phytomass of Quewus ilex L,(Holly oak) 显示文摘 | Prasad M N V Freitas H | 2000 | Environmental Pollution2000，110，2： | 1 |
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