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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | The effect of microstructure and environment on fatigue crack growth in 7049 alloy at negative stress ratios显示文摘 | Fonte Mda Romeiro F Freitas Mde Stanzl-Tschegg S E Tchegg E K Vasudevan A K | 2003 | Int J Fatigue2003，25，： | 1 |
| 3 | Effects of alpha7 positive al- losterie modulators in murine inflammatory and chronic neuropathic pain models显示文摘 | Freitas K Ghosh S Ivy Carroll F | 2013 | Neuropharmacology2013，65，： | 1 |
| 4 | The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 5 | The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 6 | Cardiac tumor: the 17- year experience of pediatric cardiolo~ department 显示文摘 | Param~s F Freitas I Martins JD | 2009 | Rev Port Cardiul2009，28，9： | 1 |
| 7 | The Notch ligand delta -like 4 negatively regulates endothelial tip cell formation and vesselbranching显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 8 | Bone conduction auditory brainstem responses in nor- mal hearing individuals显示文摘 | DE FREITAS V S DE ALVARENGA K F MORETTIN M | 2006 | Pro Fono2006，18，3： | 1 |
| 9 | The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci U S A2007，104，9： | 1 |
| 10 | The Notch ligand Delta-like 4negatively regulates endothelial tip cell formation and vessel branching显示文摘 | Suchting S Freitas C Le Nobel F | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 11 | Structural contributions for thermostability of a new endo - 1,4 -β- xylanase from the fungus humicola grisea 显示文摘 | S M De Freitas W L Treptow F P De Faria | 2003 | Internet Electronic Journal of Molecular Design2003，，2： | 1 |
| 12 | Simulating the evolution of an ethanol and gasoline source zone within the capillary fringe 显示文摘 | YU S Y FREITAS J G UNGER A J A BARKER J F CHATZIS J | 2009 | J Contam Hydrol2009，105，： | 1 |
| 13 | Co-occurrence patterns and abiotic stress in sand-dune communities:their relationship varies with spatial scale and the stress estimator显示文摘 | Maltez-Mouro S Maestre F T Freitas H | 2010 | Acta Oecologica2010，36，1： | 1 |
| 14 | Na+ glucose transporter 2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels:involvement of hepatocyte nuclear factor-1 alpha expression and activity显示文摘 | Freitas H S Anh G F Melo K F Okarnoto M M Oliveira-Souza M Bordin S | 2008 | Endocrinology2008，149，： | 1 |
| 15 | Monoamine Levels after Pilocarpine-induced Status Epilepticus in Hippocampus and Frontal Cortex of Wistar Rats 显示文摘 | Freitas R M Vasconcelos S M Souza F C | 2004 | Neurosci Lett2004，370，23： | 1 |
| 16 | Effects of feeding organic acids for piglets from 21 to 49 days 显示文摘 | De Freitas L S Lopes D C De Freitas A F et a/ | 2006 | Brazil- ian Journal of Animal Science2006，35，： | 1 |
| 17 | The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching 显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 18 | The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching显示文摘 | Suchting S Freitas C le Noble F | 2007 | Proc Natl Acad Sci U S A2007，，9： | 1 |
| 19 | Analysis and behavior of steel storage drive-in racks显示文摘 | Freitas A M S Souza F T Freitas M S R | 2010 | Thin-Walled Structures2010，48，2： | 1 |
| 20 | Biotechnology andApplied Biochemistry 显示文摘 | Sousa F Freitas S Azzoni A R | 2006 | 45(3): 131-1402006，45，3： | 1 |
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