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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Expression, purification and kinetic characterization of His-tagged glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi 显示文摘 | Cheleski J Freitas R F Wiggers H J | 2011 | Protein Expr Purif2011，76，2： | 1 |
| 3 | Sequential Monte Carlo methods to train neural network models 显示文摘 | De FREITAS J F G NIRANJAN M GEE A H | 2000 | Neural Computation2000，12，4： | 1 |
| 4 | Advances in bacterial exopolysaccharides:from production to biotechnological applications显示文摘 | Freitas F Alves VD Reis MA | 2011 | Trends Biotechnol2011，29，8： | 1 |
| 5 | The effect of microstructure and environment on fatigue crack growth in 7049 alloy at negative stress ratios显示文摘 | Fonte Mda Romeiro F Freitas Mde Stanzl-Tschegg S E Tchegg E K Vasudevan A K | 2003 | Int J Fatigue2003，25，： | 1 |
| 6 | Microbial populatiot response to changes of the operating conditions in a dynamic nutrient-removal sequencing batch reactor显示文摘 | Freitas F Temudo M Reia M A M | 2005 | Bioproces and Biosystems Engineering2005，28，3： | 1 |
| 7 | Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs显示文摘 | Freitas C F Faro R Dragosavac D | 2004 | Cardiovasc Pharmacol2004，43，1： | 1 |
| 8 | Osteopathia striata with cranial sclerosis owning to WTX gene defect显示文摘 | Perdu B de Freitas F Frints SG | 2010 | J Bone Miner Res2010，25，1： | 1 |
| 9 | Prognostic val- ue of central venous - arterial pC02 difference in severe sepsis and septic shock patients 显示文摘 | F Machado A Guarnieri FG Freitas | 2010 | Critical Care2010，14，1： | 1 |
| 10 | Sequential Monte Carlo Methods to Train Neural Network Models显示文摘 | De Freitas J F G Niranjan M A Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 11 | Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer显示文摘 | LIMA R A FREITAS E Q DIAS F L | 2006 | Head Neck2006，28，： | 1 |
| 12 | Sequential Monte Carlo Methods to Train Neural Net- work Models显示文摘 | de Freitas J F G Niranjan M Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 13 | Modification of the surface chemistry of activated carbons显示文摘 | Figueiredo J L Pereira M F Freitas M M | 1999 | Carbon1999，37，： | 1 |
| 14 | Frequency of 2,3,5 - triphenyltetrazolium chloride (TTC) non - reducing bacteria in pasteurized milk 显示文摘 | Beloti V BarroS M A F Freitas J C D | 1999 | Revista de Microbiologia1999，30，： | 1 |
| 15 | Multitemporal analysis of land use/land cover JERS-1 backscatter in the Brazilian tropical rainforest 显示文摘 | Angelis C F Freitas C C Valerno D M | 2002 | International Journal of Remote Sensing2002，23，7： | 1 |
| 16 | 3D scaffolds co-seeded with human endothelial progenitor and mesenchymal stem ceils: evidence of prevascnlarization within 7 days 显示文摘 | Duttenhoefer F Lara de Freitas R Meury T | 2013 | Eur Ceils Mater2013，26，： | 1 |
| 17 | Surface activation of a polymer based carbon显示文摘 | Samant P V Goncalves F Freitas M M A Pereira M FR Figueiredo J L | 2004 | Carbon2004，42，： | 1 |
| 18 | Modification of the surface chemistry of activated carbons显示文摘 | FIGUEIREDO J L PEREIRA M F R FREITAS M M A | 1999 | carbon1999，37，： | 1 |
| 19 | Effect of phenolic aldehydes and flavonoids on growth and inactivation of Oenococcus oeni and Lactobacillus hilgardii显示文摘 | Figueiredo A R Campos F de Freitas V | 2008 | Food Microbiology2008，25，1： | 1 |
| 20 | Use of cell block preparation for morphological,immunocytochemistry,and ploidy analysis in ThinPrep monolayer preparations显示文摘 | Freitas C Milanezi F Dias AJ | | 0，，06： | 1 |
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