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| 1 | Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population显示文摘BACKGROUND Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially regarding intermediate-grade(BCLC-B)tumors.The recently proposed Hong Kong liver cancer(HKLC)staging system appears useful but requires validation in Western populations.AIM To evaluate the agreement between BCLC and HKLC staging on the management of HCC in a Western population,estimating the overall patient survival.METHODS This was a retrospective study of HCC patients treated at a university hospital in southern Brazil between 2011 and 2016.Demographic,clinical,and laboratory data were collected.HCC staging was carried out according to the HKLC and BCLC systems to assess treatment agreement.Overall survival was estimated based on the treatment proposed in each system.RESULTS A total of 519 HCC patients were assessed.Of these,178(34.3%)were HKLC-I;95(18.3%)HKLC-IIA;47(9.1%)HKLC-IIB;29(5.6%)HKLC-IIIA;30(5.8%)HKLCIIIB;75(14.4%)HKLC-IV;and 65(12.5%)HKLC-V.According to the BCLC,25(4.9%)were BCLC-0;246(47.4%)BCLC-A;107(20.6%)BCLC-B;76(14.6%)BCLCC;and 65(12.5%)BCLC-D.The general agreement between the two systems was 80.0%-BCLC-0 and HKLC-I(100%);BCLC-A and HKLC-I/HKLC-II(96.7%);BCLC-B and HKLC-III(46.7%);BCLC-C and HKLC-IV(98.7%);BCLC-D and HKLC-V(41.5%).When sub-classifying BCLC-A,HKLC-IIB,HKLC-IIIA and HKLC-IIIB stages according to the up-to-7 in/out criterion,13.4,66.0,100 and 36.7%,respectively,of the cases were classified as up-to-7 out.CONCLUSION In a Western population,the general agreement between the two systems was 80.0%,although in BCLC-B cases the agreement was low,suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC.The authors suggest that the BCLC system should be routinely employed,although for BCLC-B cases it should be associated with the HKLC system. | Laura Bainy Rodrigues de Freitas Larisse Longo Deivid Santos Ivana Grivicich Mário Reis Alvares-da-Silva | 2019 | World Journal of Hepatology2019，11，9： | 3 |
| 2 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 3 | Sequential Monte Carlo methods to train neural network models 显示文摘 | De FREITAS J F G NIRANJAN M GEE A H | 2000 | Neural Computation2000，12，4： | 1 |
| 4 | Volume visaalization and exploration through flexible transfer function design显示文摘 | Francisco de M Pinto Carla M D S Freitas | 2008 | Computers & Graphics2008，，32： | 1 |
| 5 | Rheology and microstructural development of a Al-4%Cu alloy in the semi-solid state显示文摘 | Ferrante M Freitas E de | 1999 | Materials Science and Engineering A1999，271，： | 1 |
| 6 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 7 | Polymerization of ethylene: some aspects of metallocene cata- lyst stabilization under homogeneous and heterogeneous reac- tion conditions显示文摘 | de Freitas A J D dos Santos J H Z Meneghetti S M P | 2011 | J Appl Poiym Sci2011，119，5： | 1 |
| 8 | Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappa B activation显示文摘 | de Freitas M S Spohr T C Benedito A B | 2002 | Brain Res2002，958，： | 1 |
| 9 | Oxida- tion mechanisms occurring in wines显示文摘 | OLIVEIRA C M SILVA FERREIRA A C DE FREITAS V | 2011 | Food Res Int2011，44，5： | 1 |
| 10 | Sequential Monte Carlo Methods to Train Neural Network Models显示文摘 | De Freitas J F G Niranjan M A Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 11 | Sequential Monte Carlo Methods to Train Neural Net- work Models显示文摘 | de Freitas J F G Niranjan M Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 12 | The effect of He- licobacter pylori infection on apoptosis and cell proliferation in gastric epithelium 显示文摘 | De Freitas D Urbano M Goulao MH | 2004 | Hepatogastroenterology2004，51，57： | 1 |
| 13 | Microshear bond strength of Er:YAG-laser-treatod dentin显示文摘 | de Carvalho RC de Freitas PM Otsuki M | 2008 | Lasers Med Sci2008，23，： | 1 |
| 14 | Do transient ischemic attacks have a neuroprotective effect?显示文摘 | Moncayo J de Freitas GR Bogousslavsky J Altieri M Van Melle G | 2000 | Neurology2000，54，11： | 1 |
| 15 | Sequential Monte Carlo methods to train neural network models 显示文摘 | De Freitas N Niranjan M Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 16 | Sequential Monte Carlo methods to train neural network models 显示文摘 | Freitas J F G de Niranjan M Gee A H | 2000 | Neural Computation2000，12，4： | 1 |
| 17 | lmagmg and full length biometry of the eye during accomnlodation using spectral domain oct with an optical switch 显示文摘 | Ruggeri M Uhlhorn SR De Freitas C | 2012 | Biomedical optics express2012，3，7： | 1 |
| 18 | Light microscopy study of cisplatin-induced oto toxicity in rats显示文摘 | FREITAS M R BRITO G A DE CARVALHO J V | 2009 | Laryngol Otol2009，15，： | 1 |
| 19 | Box-behnken design for the optimization of an enantio-selectivemethod for the simultaneous analysis of propranolol and 4-hydroxypropanolol by CE显示文摘 | Borges K B Pupo M T De Freitas | 2009 | Eleetrophoresis2009，30，： | 1 |
| 20 | Method for determining the maximum allowable penetration level of distributed generation without steadystate voltage violations显示文摘 | Ayres H M Freitas W De Almeida M C | 2010 | IET Generation Transmission & Distribution2010，4，4： | 1 |
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