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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 3 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 4 | Nanoscale friction and wear mechanisms at the interface between a boron carbide film and an atomic force microscope tip 显示文摘 | PRIOLI R REIGADA D C FREIRE F L | 2000 | Journal of Applied Physics2000，87，3： | 1 |
| 5 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 6 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 7 | Panic disorder and social anxiety disorder subtypes in a caffeine challenge test显示文摘 | Nardi A E Lopes F L Freire R C | | 0，，02： | 1 |
| 8 | Fungal laccase: copper induction, semi-purification, immobilization, phenolic effluent treatment and electrochemical measurement显示文摘 | CORDI L MINUSSI R C FREIRE R S | 2010 | Aft J Bioteehnol2010，6，10： | 1 |
| 9 | Split-step Fourier migration显示文摘 | Fokkema J T Freire R M | | Geophysics0，55，： | 1 |
| 10 | Correlation between nano-scale friction and wear of boron carbide films deposited by dc-magnetron sputtering显示文摘 | Prioli R Reigada D C Freire F L | 1999 | Appl Phys Lett1999，75，9： | 1 |
| 11 | Studies on the electrochemical behavior of a eystine self-assembled monolayer modified electrode using ferro- cyanide as a probe 显示文摘 | Valber A Pedrosa Thiago R L C Paixlio Renato S Freire | 2007 | J Electroanal Chem2007，602，2： | 1 |
| 12 | Electrochemical behaviour of high strength steel wires in the presence of chlorides 显示文摘 | DIAZ B FREIRE L NOVOA X R | 2009 | Electrochimica Acta2009，54，22： | 1 |
| 13 | The subimplantation model for diamond-like carbon films deposited by methane gas decomposition 显示文摘 | Lacerda R G Marques F C Freire Jr F L | 1999 | Diamond and Related Materials1999，8，： | 1 |
| 14 | Structural assessment of minor axis steel joints using photoelasticity and finite elements 显示文摘 | Lima L R O Freire J L F Vellasco P C G S | 2009 | Journal of Constructional Steel Research2009，65，2： | 1 |
| 15 | Part 3 : Burst tests of pipeline with extensive longitudinal metal loss 显示文摘 | Freire J L F Vieira R D Castro J T P | 2006 | Experimental Techniques2006，30，6： | 1 |
| 16 | Film growth and relationship between microstructure and mechanical properties of a-C: H: F films deposited by PECVD显示文摘 | Maia da Costa M E H Jacobsohn L G | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 17 | Corporate so-cial responsibility, firm value and financial performance inBrazil显示文摘 | VICENTE L C FREIRE F S FELIPE C V | 2011 | Social Responsibility Journal2011，7，2： | 1 |
| 18 | Direct electron transfer: an approach for electrochemical biosensors with higher selectivity and sensitivity显示文摘 | FREIRE R S PESSOA C A MELLO L D | 2003 | J Braz Chem Soc2003，14，2： | 1 |
| 19 | CD4 mimetics sensitize HIV-l-infected cells to ADCC 显示文摘 | Richard J Veillette M Brassard N Iyer SS Roger M Martin L Pazgier M Schon A Freire E Routy JP SmithAB 3rd Park J Jones DM Courter JR Melillo BN Kaufmann DE Hahn BH Permar SR Haynes BF MadaniN Sodroski JG Finzi A | 2015 | Proc Natl Acad Sci USA2015，112，20： | 1 |
| 20 | Comparative effects of dietary fat and fibre in Alentejano and Large White piglets: digestibility, digestive enzymes and metabolic data 显示文摘 | Freire J P B Peiniau J Cunha L F | 1998 | Liv Prod Sci1998，53，： | 1 |
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