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| 1 | Far lateral lumbar disc herniation part 1: Imaging, neurophysiology and clinical features显示文摘Far lateral lumbar disc herniations(FLLDH)represent a separate category of disc pathology which includes both intraforaminal and extraforaminal lumbar disc herniations,that are characterized by a peculiar clinical presentation,diagnostic and treatment modalities as compared to the more frequent median and paramedian disc hernias.Surgical treatment often represents the only effective weapon for the cure of this disease and over the years different approaches have been developed that can reach the region of the foramen or external to it,with different degrees of invasiveness.The diagnosis is more demanding and still underestimated as it requires a more detailed knowledge in the spine anatomy and dedicated radiological studies.Computerized tomography and in particular magnetic resonance imaging are the appropriate tools for the diagnosis of FLLDH.Despite the widespread use of these diagnostic tests,many cases of FLLDH are overlooked due to insufficiently detailed radiological examinations or due to the execution of exams not focused to the foraminal or the extraforaminal region.Neurophysiological studies represent a valid aid in the diagnostic classification of this pathology and in some cases they can facilitate the differential diagnosis with other types of radiculopathies.In the present study,a comprehensive review of the clinical presentation,epidemiology,radiological study and the neurophysiological aspects is presented. | Luigi Valentino Berra Andrea Di Rita Federico Longhitano Enrico Mailland Paolo Reganati Alessandro Frati Antonio Santoro | 2021 | World Journal of Orthopedics2021，12，12： | 14 |
| 2 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 3 | Percutaneous coronary intervention in nonagenarians: pros and cons显示文摘Percutaneous coronary intervention is a mainstay in the management of symptomatic or high-risk coronary artery disease. The bulk of clinical evidence and experience underlying this fact relies, however, on relatively young patients. Indeed, few data of very limited quality are available which adequately define the risk-benefit and cost-benefit profile of coronary angioplasty and stenting in very old subjects, such as those of 90 years of age or older (i.e., nonagenarians). The aim of this review is to provide a concise, yet practical, synthesis of the available evidence on percutaneous coronary revascularization in the very elderly. The main arguments elaborated upon are to what extent we can extrapolate findings from studies including younger patients to nonagenarians, whether we should provide higher priority to prognosis or quality of life in such patients, and whether we can afford to allocate vast resources to care for such subjects in an era of financial constraints. Our review of 18 studies and 1082 patients suggest that percutaneous coronary intervention is feasible and associated with acceptable short- and long-term results in this population, which is nonetheless fraught with a high mortality risk irrespective of the revascularization procedure. Accordingly, the pros and cons of percutaneous coronary intervention should be carefully weighed when considering this treatment in nonagenarians. | Giuseppe Biondi Zoccai Antonio Abbate Fabrizio D'Ascenzo Davide Presutti Mariangela Peruzzi Elena Cavarretta Antonino G.M. Marullo Marzia Lotrionte Giacomo Frati | 2013 | Journal of Geriatric Cardiology2013，10，1： | 6 |
| 4 | Multi-phase post-mortem CT-angiography: a pathologic correlation study on cardiovascular sudden death显示文摘多相验尸, CT-angiography (MPMCTA ) 有大潜力增加质量验尸调查,特别在突然的死亡的区域;然而,它到病理工具箱的平淡的补充仍然作为它被询问的角色需要进一步被标准化。这研究的目的是在成年人并且特别地在突然的心血管的死亡在突然的 unexplained 死亡的情况下调查 MPMCTA 的贡献。成年人的 68 突然的意外死亡在我们在 2012 和 2013 之间的机构被调查。十个案例经历了 MPMCTA 和尸体并且在学习被包括。在由脉管的系统的完全的充满的 angiographic 步前,在身体的任何操作以前,非对比 CT 扫描被执行。图象重建在一个 CT 工作站(Vitrea ) 上被执行,与帖子 mortem 成像经验丰富的二个放射线学者解释了 MPMCTA 调查结果。在所有 10 个案例中,我们能说在联合之间的好关联验尸 CT 和 MPMCTA 和尸体过程,证实高诊断的敏感。当面对突然的死亡时,与这个案例系列,我们想要说明执行 MPMCTA 提供的优点,不管为急性冠的症候群或脉管的其它或 ischemic 疾病的特定的怀疑。 | Emanuela Turillazzi Paola Frati Natascha Pascale Cristoforo Pomara Giampaolo Grilli Rocco Valerio Viola Vittorio Fineschi | 2016 | Journal of Geriatric Cardiology2016，13，10： | 2 |
| 5 | Effects of ischemia and reperfusion on QT dispersin during coronary angioplasty 显示文摘 | Michelucei A Padeletti L Frati M | 1996 | Pace1996，19，11： | 1 |
| 6 | Lichens as biomonitors of depleted uranium in kosovo显示文摘 | Loppis A Frati A | 2004 | Journal of Atmospheric Chemistry2004，49，： | 1 |
| 7 | Mlozyme variation in reference and metal-exposed natural populations of Wrchesella cincta(Insecta: Collembola) 显示文摘 | FRATI F FANCIULLI P P POSTHUMA L | 1992 | Biochem Syst Ecol1992，，： | 1 |
| 8 | Emerging role of peme- trexed in ovarian Cancer显示文摘 | Tomao F Panici PB Frati L | 2009 | Expert Rev Anticancer Ther2009，9，12： | 1 |
| 9 | Epidemiological and clinical data of amniotie fluid embolism in forensic settings 显示文摘 | Busardo FP Frati P Kareh SB | 2014 | Curr Pharm Bioteehnol2014，14，14： | 1 |
| 10 | Atypical tentorial meningioma 30 years after radiotherapy for a pituitary adenoma显示文摘 | A. Santoro G. Minniti S. Paolini E. Passacantilli P. Missori A. Frati G. P. Cantore | 2002 | Neurological Sciences2002，，6： | 1 |
| 11 | Evolution, weighting, and phylogenetic utility of mitochondrial gene sequences and a compilation of conserved polymerase chain reaction primers 显示文摘 | SIMON C FRATI F BECKENBACH A | 1994 | Annals of the Entomological Society of America1994，87，： | 1 |
| 12 | Isolation and expansion of adult cardiac stem cells from human and murine heart显示文摘 | Messina E De Angelis L Frati G | | 0，，09： | 1 |
| 13 | Contribution of Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Women with Early StageEndometrial Cancer: Results of the SENTI - ENDO Study 显示文摘 | Frati A Ballester M Dubernard G | 2014 | Ann Surg Oncol2014，，： | 1 |
| 14 | Central nervous system mesenehymal ehondrosarcoma 显示文摘 | Salvati M Caroli E Frati A | 2005 | J Exp Clin Cancer Res2005，24，2： | 1 |
| 15 | Evolution,weighting,and phylogenetic utility of mitochondrial gene sequences and a compilation of conserved polymerase chain reaction primers显示文摘 | SIMON C FRATI F BECKENBACH A | 1994 | Ann Entomol Soc Am1994，87，： | 1 |
| 16 | A modified technique for repair of the anomalous origin of the right pulmonary显示文摘 | Prifti E Frati G Crucean A | | 0，，01： | 1 |
| 17 | Evolution, weighting and phylogenetic utility of mitochondrial gene sequences and a compilation of conserved polymerase chain reaction primers显示文摘 | Simon C Frati F Beckenbach A | 1994 | Annals of the Entomological Society of America1994，87，6： | 1 |
| 18 | Low doses of etanercept can be effective to maintain remission in ankylosing spondylitis patients显示文摘 | De Stefano R Frati E De Quattro D | 2014 | Clin Rheumatol2014，33，5： | 1 |
| 19 | Robot-assisted laparoscopy for infertility treatment: current views显示文摘 | Carbonnel M Goetgheluck J Frati A | 2014 | Fertil Steril2014，101，3： | 1 |
| 20 | Effects of ischemia and reperfusion on QT dispersin during coronary angioplasty显示文摘 | Michelucci A Padeletti L Frati M | 1996 | Pace1996，19，11： | 1 |
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