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| 1 | Interventions to improve sarcopenia in cirrhosis: A systematic review显示文摘BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings. | Maliha Naseer Erica P Turse Ali Syed Francis E Dailey Mallak Zatreh Veysel Tahan | 2019 | World Journal of Clinical Cases2019，7，2： | 8 |
| 2 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 3 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 4 | A new language for neuronal dynamics 显示文摘 | So P Francis J T Netoff T I | 1998 | Biophys Journal1998，74，6： | 2 |
| 5 | 基于砂—粉砂—黏土含量的沉积物命名方法显示文摘 | Francis P Shepard 王中波 | 2006 | 海洋地质动态2006，22，10： | 2 |
| 6 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 7 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 8 | Sequential interpenetrating polymer networks from bisphenol A based cyanate ester and bimaleimide: Properties of the neat resin and composites 显示文摘 | Reghunadhan Nair C P Francis Tania Vijayan T M | 1999 | Journal of Applied Polymer Science1999，74，： | 1 |
| 9 | Insulin-like growth factors in poultry 显示文摘 | MCMURTYR J P FRANCIS G L UPTON Z | 1997 | Domest Anim Endocrinol1997，14，4： | 1 |
| 10 | Finite Basis Set Corrections to Total Energy Pseudopotential Calculations显示文摘 | Francis G P Payne M C | 1990 | J Phys Condens Matter1990，2，19： | 1 |
| 11 | Costs of Equity and Earnings Attributes显示文摘 | Lafond R Olsson P M Schipper K | 2004 | The Accounting Review2004，79，4： | 1 |
| 12 | Plant responses of ultra narrow row cotton to nitrogen fertilization显示文摘 | MCCONNEL J S Francis P B Stark C R | 2008 | Journal of Plant Nutrition2008，31，： | 1 |
| 13 | Formation of thaumasite in synthetic cement mineral slurries显示文摘 | Purnell P Francis O J Page C L | 2003 | Cem Concr Compos2003，25，： | 1 |
| 14 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 15 | Antinutri- tional factors present in plant-derived alternate fish feed ingredients and their effects in fish 显示文摘 | FRANCIS G MAKKAR H P S KLAUS B K | 2001 | Aquaculture2001，199，： | 1 |
| 16 | Barrier Lyapunovfunctions for the control of output-constrained nonlin-ear systems 显示文摘 | Keng P T Ge S S Francis E H | 2009 | Automatica2009，45，4： | 1 |
| 17 | The Volatile Composition of Chardonnay Juices a Study by Flavor precursor Analysis显示文摘 | Sefton M A Francis I L Williams P J | 1993 | American Journal of Enology and Viticulture1993，44，4： | 1 |
| 18 | Short term acute heat stress in rabbits:functional,metabolic and immunological effects显示文摘 | Amici A Franci O Mastroiacono P | 2010 | World Rabbit Science2010，8，1： | 1 |
| 19 | The site of brains tern lesions causing semicircular canal paresis:an MRI study显示文摘 | Francis DA Bronstein AM Rudge P | 1992 | J Neurol Neurosurg Psychiatry1992，55，： | 1 |
| 20 | 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)显示文摘 | Hani Jneid Jeffrey L. Anderson R. Scott Wright Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2012 | Journal of the American College of Cardiology2012，，7： | 1 |
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