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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Surgical treat- ment of congenital pulmonary arteriovenous fistula in children 显示文摘 | Fraga JC Favero E Contelli F | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 3 | Epigenetic differences arise during the lifetime of monozygotic twins 显示文摘 | Fraga M F Ballestar E Paz M F | 2005 | Proc Natl Acad Sci2005，102，10： | 1 |
| 4 | Epige- netic differences arise during the lifetime of monozy- gotic twins 显示文摘 | FRAGA M F BALLESTAR E PAZ M F | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，10： | 1 |
| 5 | Kinetic and thermodynamic studies of an epoxy system diglycidyl ether of bisphenol K/1, 2 diamine cyelohexane/calcium carbonate filler显示文摘 | Nunez L Fraga F Castro A | 2000 | Journal of Applied Polymer Science2000，75，： | 1 |
| 6 | Epigenetic differences arise during the lifetime of monozygotic twins显示文摘 | Fraga M F Ballestar E Paz M F | 2005 | Proc Natl Acad Sd U S A2005，102，10： | 1 |
| 7 | Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer 显示文摘 | Aguilera O Fraga M F Ballestar E | 2006 | Oncogene2006，25，29： | 1 |
| 8 | Comparison be- tween warm blood and crystalloid cardioplegia during open heart surgery显示文摘 | Ferrira R Fraga C Carrasquedo F | 2003 | Int J Cardiol2003，90，23： | 1 |
| 9 | High-performance capillary electrophoretic method for the quantification of 5-methyl 2′-deoxycytidine in genomic DNA:Application to plant,animal and human cancer tissues显示文摘 | Fraga M F Uriol E Borja Diego L | 2002 | Electrophoresis2002，23，11： | 1 |
| 10 | DNA methyhransferases control telomere length and telomere recombination in mammalian cells 显示文摘 | Gonzalo S Jaco I Fraga M F | 2006 | Nat Cell Biol2006，8，4： | 1 |
| 11 | Randomized comparison between laparoscopic and robot-assisted nerve-sparing radical prostatectomy显示文摘 | Asimakopoulos AD Pereira Fraga CT Annino F | | 0，，05： | 1 |
| 12 | Antibacterial Effects of Endodontic Irrigants on Black-pigmented Gram-negative Anaerobes and Facultative Bacteria显示文摘 | Siqueira J F Batista M Fraga R | 1998 | Journal of Endodontics1998，24，6： | 1 |
| 13 | DNA methylation: a promising landscape for immune sys-tem-related diseases 显示文摘 | Suarez-Alvarez B Rodriguez R M Fraga M F | 2012 | Trends Genet2012，28，10： | 1 |
| 14 | DNA Methyltransferases Control Telomere Length and Telomere Recombination in Mammalian Cells显示文摘 | GONZALO S JACO I FRAGA M F | 2006 | Nature Cell Biol2006，8，： | 1 |
| 15 | Genomic DNA methylationdemethylation during aging and reinvigoration of Pinus radiata 显示文摘 | Fraga M F Rodriguez R Canal M J | 2002 | Tree Physiol2002，22，： | 1 |
| 16 | TIT cure diagram for an epoxy system diglycidyl ether of bisphenol A/1,2diamine cyclphexane/cal- cium carbonate filler 显示文摘 | Nunez L Fraga F Castro A | 2001 | Polymer2001，42，8： | 1 |
| 17 | Upwelling-downwelling sequences in the generation of red tides in a coastal upwelling system显示文摘 | TILSTONE G H FIGUEIRAS F G FRAGA F | 1994 | Marine Ecology Progress Series1994，112，： | 1 |
| 18 | Epigenetic differences arise during the life time of monozygotic twins显示文摘 | Fraga M F Ballestar E Paz M F | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 19 | Detection and genetic distance of resistant populations of Pseudosuccinea columella (Mollusca:Lymnaeidae) to Fasciola hepatica (Trematoda:Digenea) using RAPD markers显示文摘 | Calienes A F Fraga J Pointier J P | 2004 | Acta Trop2004，92，1： | 1 |
| 20 | TTT cure diagram for an epoxy system diglycidyl ether of bisphenol A/l, 2 diamine cyclohexane/calcium carbonate filler显示文摘 | NUNEZ L FRAGA F CASTRO A | 2001 | Polymer2001，42，8： | 1 |
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