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| 1 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 2 | Effects of protein content and composition on white noodle making quality: color 显示文摘 | Wang C Kovacs M I P Fowler D B | 2004 | Cereal Chemistry2004，81，： | 1 |
| 3 | Effect of carvedilol on survival in severe chronic heart failure显示文摘 | Packer M Coats AJ Fowler MB Katus HA Krum H Mohacsi P | 2001 | N Engl J Med2001，344，： | 1 |
| 4 | Assessment ofovarian reserve-should we perform tests of ovarian reserveroutinely? 显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，： | 1 |
| 5 | HLA-A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection显示文摘 | Nayersina R Fowler P | 1993 | J lmmunol1993，150，10： | 1 |
| 6 | The Haddon matrix:Applying an epidemiologic research tool as a framework for death inveatigation显示文摘 | Conroy Carol M P H Fowler John B S | 2000 | The America Journal of Forensic Medicine and Pathalogy2000，21，04： | 1 |
| 7 | Imaging Techniques for the Assessment of Body Composition 显示文摘 | Fuller M F Fowler P A McNeil1 G | 1994 | Nutr1994，124，： | 1 |
| 8 | Assessment of ovarian reserve--should we perform tests of ovarian reserve routinely?显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，11： | 1 |
| 9 | Assessment of ovarian reserve-should we perform tests of ovarian reserve routinely? 显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，： | 1 |
| 10 | Interplanetary flyby mission optimization using a hybrid global/local search method显示文摘 | Crain T P Bishop R H Fowler W T | 2000 | Journal of Spacecraft and Rockets2000，37，4： | 1 |
| 11 | Robotic assistance improves minimally invasive surgery for endometrial cancer 显示文摘 | Boggess JF Fowler WC Jr Gehrig P | 2007 | Gynecol Oncol2007，104，： | 1 |
| 12 | A stable non- classical metallofullerene family显示文摘 | Stevenson S Fowler P W Heine T | 2000 | Nature2000，408，6811： | 1 |
| 13 | Noninvasive papillary serous carcinoma of the endometrium显示文摘 | Cehrig P A Groben P A Fowler W C | 2001 | Obstet Gynecol2001，97，1： | 1 |
| 14 | Bar-code technology for medication administration: medication errors and nurse sa- tisfaction显示文摘 | Fowler S B Sohler P Zarillo D F | 2009 | Medsurg Nuts2009，18，2： | 1 |
| 15 | The preparation and characterization of a series of chemically modified potato starches显示文摘 | FANG J M FOWLER P A TOMKINSON J | 2002 | Carbohydrate Polymers2002，47，3： | 1 |
| 16 | Overian follicular dynamics in the llama显示文摘 | Fowler M E Stabenfeldt G H | 1990 | Biol Reprod1990，43，： | 1 |
| 17 | The preparation and characterization of a series of chemically modified potato starches显示文摘 | Fang J M Fowler P A Tomkinson J | 2002 | Carbohydrate Polymers2002，47，3： | 1 |
| 18 | Multidetector computed tomography for acute pulmonary embolism显示文摘 | Stein P D Fowler S E Goodman L R | | 0，，22： | 1 |
| 19 | Barcode technology for medication administration:medication errors and nurse samfaction显示文摘 | Fowler SB Sohler P Zarillo DF | 2009 | Medsurg Nurs2009，18，2： | 1 |
| 20 | 显示文摘 | ALBERTAZZI E DOMENE C FOWLER P W | 1999 | Phys Chem Chem Phys1999，1，： | 1 |
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