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| 1 | Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection显示文摘AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: < 0.01, < 0.05, < 0.001 and < 0.001, respectively. Among the studied parameters, AAR and GUCI gave the highest diagnostic accuracy (80.5%) with cutoff values of 1.2 and 1.5, respectively. APRI, API and GUCI were significantly correlated with the stage of fibrosis (P < 0.001) and the grade of activity (P < 0.001, < 0.001 and < 0.005, respectively), while CDS only correlated significantly with the stage of fibrosis (P < 0.001) and not with the degree of activity (P > 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: < 0.001, < 0.05, < 0.001, < 0.001 and < 0.005, respectively; CDS did not demonstrate significant correlation (P > 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis, especially in Egypt, where resources are limited. | Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 2 | Flow cytometric detection of hepatitis C virus antigens in infected peripheral blood leukocytes: Binding and entry显示文摘AIM: We designed two synthetic-core-specific peptides core 1 (C1) and core 2 (C2), and an E1-specific peptide (E1). We produced specific polyclonal antibodies againstthese peptides and used the antibodies for detection of HCV antigens on surface and within infected peripheral blood leukocytes.METHODS: Peripheral blood from a healthy individual who tested negative for HCV RNA was incubated with HCV type 4 infected serum for 1 h and 24 h at 37 ℃. Cells were stained by direct and indirect immunofluorescence and measured by flow cytometry.RESULTS: After 1 h of incubation, antibodies against C1,C2, and E1 detected HCV antigens on the surface of 27%,26% and 73% of monocytes respectively, while 10%, 5% and 9% of lymphocytes were positive with anti-C1, anti-C2 and anti-E1 respectively. Only 1-3% of granulocytes showed positive staining with anti-C1, anti-C2 and anti E1 antibodies. After 24 h of incubation, we found no surface staining with anti-C1, anti-C2 or anti-E1. Direct immunostaining using anti-C2 could not detect intracellular HCV antigens, after 1 h of incubation with the virus, while after 24 h of incubation, 28% of infected cells showed positive staining. Only plus strand RNA was detectable intracellularly as early as 1 h after incubation, and remained detectable throughout 48 h post-infection.Interestingly, minus RNA strand could not be detected after 1 h, but became strongly detectable intracellularly after 24 h post-infection.CONCLUSION: Monocytes and lymphocytes are the preferred target cells for HCV infection in peripheral blood leukocytes. Our specific anti-core and anti-E1 antibodies are valuable reagents for demonstration of HCV cell cycle.Also, HCV is capable of infecting and replicating in peripheral blood mononuclear cells as confirmed by detection of minus strand HCV RNA as well as intracellular staining of core HCV antigen. | Mostafa K El-Awady Ashraf A Tabll El-Rashdy M Redwan Samar Youssef Moataza H Omran Fouad Thakeb Maha El-Demellawy | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 3 | Surface to bulk characterization of phosphate modified aluminas显示文摘 | Mekhemer G A H Nohman A K H Fouad N E | 2000 | Colloids and Surfaces A Physicochemical and Engineering Aspects2000，161，3： | 1 |
| 4 | Letro- zole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the pe- riod of infertility, the body mass index, or the luteinizing hor- mone/folliele-stimulating hormone ratio 显示文摘 | ELNASHAR A FOUAD H ELDOSOKY M | 2006 | Fertil Steril2006，85，2： | 1 |
| 5 | Stability Boundary Approximation of a Power Sustem Using the Real Normal Form of Vector Fields显示文摘 | Saha S Fouad A A Kliemann W H | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 6 | Prognostic significance of per- itumoral lymphatic vessel density and vascular endothelial growth factor receptor 3 in invasive squamous cell cervical cancer 显示文摘 | Botting SK Fouad H Elwell K | 2010 | Transl Oncol2010，3，3： | 1 |
| 7 | Prognostic signifi- cance of peritumoral lymphatic vessel density and vascu- lar endothelial growth factor receptor 3 in invasive squa- mous cell cervical cancer显示文摘 | Botting SK Fouad H Elwell K | 2010 | Transl Oncol2010，3，3： | 1 |
| 8 | Role of antioxidants in gestational diabetes mellitus and relation to fetal outcome:a randomized controlled trial显示文摘 | Maged AM Torky H Fouad MA | 2016 | J Matern Fetal Neonatal Med2016，21，： | 1 |
| 9 | Letrozole induction of ovulation in women with Clomiphene Citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/ follicle-stimulating hormone ratio 显示文摘 | Elnashar A Fouad H Eldosoky M | 2006 | Fertil Steril2006，85，2： | 1 |
| 10 | Granular Myringitis: Is It a Surgical Problem显示文摘 | El-Seifi h Fouad B | 2000 | Am J Otol2000，21，4： | 1 |
| 11 | Stability Boundaty Approximation of a Power System Using the Real Normal Form of Vector Fields显示文摘 | Saha S A A Fouad Kliemann W H | | 0，，： | 1 |
| 12 | Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio 显示文摘 | ELNASAR A FOUAD H ELDOSOKY M | 2006 | Fertil Steril2006，85，2： | 1 |
| 13 | Factors iniluendng in vitro establishment and multiplication stages of peach显示文摘 | Fouad M M Gomaa A H El Zahar M H A | 1995 | Acta Horticulture1995，409，： | 1 |
| 14 | Factors influencing in vitro establishment and multiplication stages of peach显示文摘 | FOUAD M M GOMAA A H ELZAHER M H A | 1995 | Acta Horticulture1995，，409： | 1 |
| 15 | Stability boundary approximation of a power system using the real normal form of vector fields显示文摘 | Saha S Fouad A A Kiliemann W H | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 16 | Deteetion of aherrant pl6INK4A methylation in sera of patients with HCV-related liver diseases : An Egyptian study 显示文摘 | Ahmed R Salama H Fouad A | 2010 | Med Sci Monit2010，16，9： | 1 |
| 17 | Real-time shot transition detection in compressed MPEG video streams显示文摘 | FOUAD M A BAYOUMI F M ONSI H M | 2008 | Journal of Electronic Imaging2008，17，2： | 1 |
| 18 | Stability boundary approximation of a power system using the real normal form of vector fields 显示文摘 | Saha S Fouad A A Kiliemann W H | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 19 | Perceptually motivated automatic dance motion generation for music 显示文摘 | Kim J W Fouad H Sibert J L | 2009 | Computer Animation and Virtual World2009，20，23： | 1 |
| 20 | Processing of polymer nanofibers through electrospinning as drug delivery systems显示文摘 | Kenawy E R Fouad I Mohamed H | 2009 | Mater Chem Phys2009，113，1： | 1 |
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