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| 1 | Th17 cells and their associated cytokines in liver diseases显示文摘T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune disease.The functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and IL-22.Recent studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular carcinoma.IL-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the liver.IL-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation. | Fouad Lafdil Andrew M Miller Sung Hwan Ki Bin Gao | 2010 | Cellular & Molecular Immunology2010，7，4： | 29 |
| 2 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 3 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 4 | Effect of Aging on the Toughness of Austenitic and Duplex Stainless Steel Weldments显示文摘In the present study,the effect of aging heat treatment at 650,750,and 850?C on the impact toughness of 316L austenitic stainless steel,2205 duplex stainless steel and their weldments has been investigated.Welding process was conducted using the TIG(tungsten inert gas) welding technique.Instrumented impact testing,at room temperature,was employed to determine the effect of aging treatment on the impact properties of investigated materials.Aging treatment resulted in degradation in the impact toughness as demonstrated by the reduction in the impact fracture energy and deformation parameters(strain hardening capacity,fracture deffection,and crack initiation and propagation energy).The degree of embrittlement was more noticeable in duplex stainless steel parent and weld-metal than in 316L stainless steel and became greater with the increase of aging temperature.The degradation in impact toughness was discussed in relation to the observed precipitation of the intermetallic sigma phase in the microstructure of the stainless steel weldments and the corresponding fracture surface morphology. | Omyma Hassan Ibrahim Ibrahim Soliman Ibrahim Tarek Ahmed Fouad Khalifa | 2010 | Journal of Materials Science & Technology2010，26，9： | 12 |
| 5 | Infrared upconversion imaging in nonlinear metasurfaces显示文摘Infrared imaging is a crucial technique in a multitude of applications,including night vision,autonomous vehicle navigation,optical tomography,and food quality control.Conventional infrared imaging technologies,however,require the use of materials such as narrow bandgap semiconductors,which are sensitive to thermal noise and often require cryogenic cooling.We demonstrate a compact all-optical alternative to perform infrared imaging in a metasurface composed of GaAs semiconductor nanoantennas,using a nonlinear wave-mixing process.We experimentally show the upconversion of short-wave infrared wavelengths via the coherent parametric process of sum-frequency generation.In this process,an infrared image of a target is mixed inside the metasurface with a strong pump beam,translating the image from the infrared to the visible in a nanoscale ultrathin imaging device.Our results open up new opportunities for the development of compact infrared imaging devices with applications in infrared vision and life sciences. | Rocio Camacho-Morales Davide Rocco Lei Xu Valerio Flavio Gili Nikolay Dimitrov Lyubomir Stoyanov Zhonghua Ma Andrei Komar Mykhaylo Lysevych Fouad Karouta Alexander Dreischuh Hark Hoe Tan Giuseppe Leo Costantino De Angelis Chennupati Jagadish Andrey E.Miroshnichenko Mohsen Rahmani Dragomir N.Neshev | 2021 | Advanced Photonics2021，3，3： | 11 |
| 6 | Hepato-cardiac disorders显示文摘Understanding the mutual relationship between the liver and the heart is important for both hepatologists and cardiologists. Hepato-cardiac diseases can be classified into heart diseases affecting the liver, liver diseases affecting the heart, and conditions affecting the heart and the liver at the same time. Differential diagnoses of liver injury are extremely important in a cardiologist's clinical practice calling for collaboration between cardiologists and hepatologists due to the many other diseases that can affect the liver and mimic haemodynamic injury. Acute and chronic heart failure may lead to acute ischemic hepatitis or chronic congestive hepatopathy. Treatment in these cases should be directed to the primary heart disease. In patients with advanced liver disease, cirrhotic cardiomyopathy may develop including hemodynamic changes, diastolic and systolic dysfunctions, reduced cardiac performance and electrophysiological abnormalities. Cardiac evaluation is important for patients with liver diseases especially before and after liver transplantation. Liver transplantation may lead to the improvement of all cardiac changes and the reversal of cirrhotic cardiomyopathy. There are systemic diseases that may affect both the liver and the heart concomitantly including congenital, metabolic and inflammatory diseases as well as alcoholism. This review highlights these hepatocardiac | Yasser Mahrous Fouad Reem Yehia | 2014 | World Journal of Hepatology2014，6，1： | 10 |
| 7 | Food legume production in China显示文摘Food legumes comprise all legumes grown for human food in China as either dry grains or vegetables,except for soybean and groundnut.China has a vast territory with complex ecological conditions.Rotation,intercropping,and mixed cropping involving pulses are normal cropping systems in China.Whether indigenous or introduced crops,pulses have played an important role in Chinese cropping systems and made an important contribution to food resources for humans since ancient times.The six major food legume species(pea,faba bean,common bean,mung bean,adzuki bean,and cowpea) are the most well-known pulses in China,as well as those with more local distributions;runner bean,lima bean,chickpea,lentil,grass pea,lupine,rice bean,black gram,hyacinth bean,pigeon pea,velvet bean,winged bean,guar bean,sword bean,and jack bean.China has remained the world's leading producer of peas,faba beans,mung beans,and adzuki beans in recent decades,as documented by FAO statistics and China Agriculture Statistical Reports.The demand for food legumes as a healthy food will markedly increase with the improvement of living standards in China.Since China officially joined the World Trade Organization(WTO) in2001,imports of pea from Canada and Australia have rapidly increased,resulting in reduced prices for dry pea and other food legumes.With reduced profits for food legume crops,their sowing area and total production has decreased within China.At the same time,the rising consumer demand for vegetable food legumes as a healthy food has led to attractive market prices and sharp production increases in China.Vegetable food legumes have reduced growing duration and enable flexibility in cropping systems.In the future,production of dry food legumes will range from stable to slowly decreasing,while production of vegetable food legumes will continue to increase. | Ling Li Tao Yang Rong Liu Bob Redden Fouad Maalouf Xuxiao Zong | 2017 | The Crop Journal2017，5，2： | 7 |
| 8 | 饲粮棕榈粕添加水平对产蛋期蛋鸭产蛋性能、蛋品质、器官发育及抗氧化功能的影响显示文摘本研究旨在探讨饲粮棕榈粕添加水平对产蛋期蛋鸭产蛋性能、蛋品质、器官发育及抗氧化功能的影响,为生产中棕榈粕在蛋鸭饲粮中的科学应用提供参考。选择600只健康的20周龄福建龙岩麻鸭,随机分为5个组,每组6个重复,每个重复20只鸭。各组蛋鸭分别饲喂棕榈粕添加水平为0、3%、6%、9%和12%的试验饲粮。试验期12周。结果表明:饲粮棕榈粕添加水平对蛋鸭平均蛋重、蛋黄重和蛋壳重有显著影响(P<0.05),随着饲粮棕榈粕添加水平的升高,平均蛋重、蛋黄重和蛋壳重呈下降趋势;饲粮棕榈粕添加水平对其他产蛋性能和蛋品质指标均无显著影响(P>0.05)。饲粮棕榈粕添加水平对蛋鸭血浆和肝脏抗氧化指标及器官重量均无显著影响(P>0.05)。由此可见,以平均蛋重为评价指标,推荐蛋鸭饲粮中棕榈粕添加水平不高于3%;饲粮中棕榈粕添加水平达6%~12%时可降低平均蛋重,但并未影响蛋鸭器官发育和抗氧化功能。 | 王爽 张亚男 AHMED MOHAMED FOUAD 陈伟 阮栋 夏伟光 黄雪冰 李凯潮 郑春田 | 2020 | 动物营养学报2020，32，3： | 6 |
| 9 | Identification and Cloning of Differentially Expressed Genes Involved in the Interaction Between Potato and Phytophthora infestans using a Subtractive Hybridization and cDNA-AFLP Combinational Approach显示文摘Using a subtractive hybridization (SH)/cDNA-AFLP combinational approach,differentially expressed genes involved in the potato-Phytophthora infestans interaction were identified.These included genes potentially controlling pathogenesis or avr genes in P.infestans as well as those potentially involved in potato resistance or susceptibility to this pathogen.Forty-one differentially expressed transcriptderived fragments (TDFs),resulting from the interaction,were cloned and sequenced.Two TDFs,suggested as potential pathogenicity factors,have sequence similarity to N-succinyl diaminopimelate aminotransferase and a transcriptional regulator,TetR family gene,respectively.Two other TDFs,suggested as potential avr genes,have sequence similarity to an EST sequence from Avr4/Cf-4/Avr9/Cf9 and a P.infestans avirulence-associated gene,respectively.Genes’ expression and origin were confirmed using Southern blots,Northern blots and qRT-PCR.I.e.,potential resistance gene DL81 was induced at 12 hpi in the moderately resistant cultivar,whereas it was down-regulated as early as 6 hpi in the susceptible cultivar.On the other hand,DL21 was induced at 6 hpi (3.38-fold) in response to the highly aggressive isolate (US8) and strongly up-regulated thereafter (25.13-fold at 120 hpi.),whereas it was only slightly up-regulated in response to the weakly aggressive isolate US11 (3.82-fold at 96 hpi),suggesting its potential involvement as a susceptibility gene. | Maria Antonia Henriquez Fouad Daayf | 2010 | Journal of Integrative Plant Biology2010，52，5： | 6 |
| 10 | Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection显示文摘AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: < 0.01, < 0.05, < 0.001 and < 0.001, respectively. Among the studied parameters, AAR and GUCI gave the highest diagnostic accuracy (80.5%) with cutoff values of 1.2 and 1.5, respectively. APRI, API and GUCI were significantly correlated with the stage of fibrosis (P < 0.001) and the grade of activity (P < 0.001, < 0.001 and < 0.005, respectively), while CDS only correlated significantly with the stage of fibrosis (P < 0.001) and not with the degree of activity (P > 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: < 0.001, < 0.05, < 0.001, < 0.001 and < 0.005, respectively; CDS did not demonstrate significant correlation (P > 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis, especially in Egypt, where resources are limited. | Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 11 | Chronic permanent hypoxemia predisposes to mild elevation of liver stiffness显示文摘AIM:To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver stiffness.METHODS:We included ten adult patients with non operated inoperate cyanotic cardiopathy and ten matched patients for age and gender admitted to the gastroenterology department for proctologic diseases;Clinical and laboratory data were collected[age,gender,body mass index,oxygen saturation,glutamate oxaloacetate transaminase(GOT),glutamate pyruvate transaminase(GPT),glycemia and cholesterol].Measurement of hepatic stiffness by transient elastography was carried out in all patients using the Fibroscan device.All patients underwent an echocardiography to eliminate congestive heart failure.RESULTS:Among the patients with cyanotic cardiopathy,median liver stiffness 5.9±1.3 kPa was greater than control group(4.7±0.4 kPa)(P=0.008).Median levels of GOT,GPT,gamma-glutamyltransferase,glycemia and cholesterol were comparable in cardiopathy and control group.In regression analysis including age,gender,body mass index,oxygen saturation,GOT,GPT,glycemia,cholesterol showed that only oxygen saturation was related to liver stiffness(r=-0.63 P=0.002).CONCLUSION:Chronic permanent hypoxemia can induce mild increase of liver stiffness,but further studies are needed to explore the histological aspects of liver injury induced by chronic permanent hypoxemia. | Mohamed Tahiri Abdenasser Drighil Yasmine Jalal Dounia Ghellab Wafaa Hliwa Haddad Fouad Wafaa Badre Ahmad Bellabah Rachida Habbal Rhimou Alaoui | 2014 | World Journal of Gastroenterology2014，20，30： | 5 |
| 12 | Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)has progressively increased in recent years and is now thefifth and the second most common cancer in the World and in Egypt,respectively.Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions.Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies.Although a number of biomarkers have been identified,none have been considered reliable indicators of early HCC lesions.This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use.Furthermore,we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. | Mahmoud Khattab Magdy Fouad Elham Ahmed | 2015 | World Journal of Hepatology2015，7，23： | 5 |
| 13 | Termites and Chinese agricultural system: applications and advances in integrated termite management and chemical control显示文摘Termites are eusocial arthropod decomposers,and improve soil fertility,crop yield,and also are used by humans for their ben efits across the world.However,some species of termites are becoming a threat to the farming community as they are directly and indirectly causing major losses to the agricultural system.It is estimated that termites cost the global economy more than 40 billion USD annually,and considerable research has been done on their management.In this review,we present the available information related to sustainable and integrated termite management practices(ITM).Furthermore,we insist that the better management of this menace can be possible through:(i)improving traditional methods to keep termites away from crops;(ii)improving agricultural practices to maintain plants with more vigor and less susceptible to termite attack;and(iii)integration of available techniques to reduce termite infestation in crops and surroundings.The application of an effective combination of traditional practices with recently developed approaches is the best option for agricultural growers.Moreover,keeping in mind the beneficial nature of this pest,more innovative efforts for its management,particularly using rapidly emerging technology(e.g.,RNA interference),are needed. | Farhan Ahmad Hatem Fouad Shi-You Liang Yin Hu Jian-Chu Mo | 2021 | Insect Science2021，28，1： | 5 |
| 14 | Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects显示文摘BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide.These defects generally result from severe trauma or resection of a whole large tumour.Autologous bone grafts are the current gold standard for the reconstruction of such defects.However,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be introduced.To find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone regeneration.AIM To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat model.METHODS Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur.Rats were allocated to three equal groups of 21 rats each.Group I bone defects were irrigated with normal saline and designed as negative controls.Defects of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs.Seven rats from each group were killed at 1,2 and 4 wk.The mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical staining.RESULTS Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone. | Muhammad A Awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish | 2020 | World Journal of Stem Cells2020，12，1： | 4 |
| 15 | Barrett's esophagus:Prevalence and risk factors in patients with chronic GERD in Upper Egypt显示文摘AIM:To determine the prevalence and possible risk factors of Barrett's esophagus(BE) in patients with chronic gastroesophageal reflux disease(GERD) in El Minya and Assuit, Upper Egypt.METHODS:One thousand consecutive patients with chronic GERD symptoms were included in the study over 2 years.They were subjected to history taking including a questionnaire for GERD symptoms, clinical examination and upper digestive tract endoscopy.Endoscopic signs suggestive of columnar-lined esophagus(CLE) were defined as mucosal tongues or an upward shift of the squamocolumnar junction.BE was diagnosed by pathological examination when specialized intestinal metaplasia was detected histologically in suspected CLE.pH was monitored in 40 patients.RESULTS:BE was present in 7.3% of patients with chronic GERD symptoms, with a mean age of 48.3 ± 8.2 years, which was signif icantly higher than patients with GERD without BE(37.4 ± 13.6 years).Adenocarcinomawas detected in eight cases(0.8%), six of them in BE patients.There was no signiflcant difference between patients with BE and GERD regarding sex, smoking, alcohol consumption or symptoms of GERD.Patients with BE had significantly longer esophageal acid exposure time in the supine position, measured by pH monitoring.CONCLUSION:The prevalence of BE in patients with GERD who were referred for endoscopy was 7.3%.BE seems to be associated with older age and more in patients with nocturnal gastroesophageal reflux. | Yasser M Fouad Madiha M Makhlouf Heba M Tawfik Hussein El Amin Wael Abdel Ghany Hisham R El-khayat | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 16 | Electron-Induced Perpendicular Graphene Sheets Embedded Porous Carbon Film for Flexible Touch Sensors显示文摘Graphene-based materials on wearable electronics and bendable displays have received considerable attention for the mechanical flexibility,superior electrical conductivity,and high surface area,which are proved to be one of the most promising candidates of stretching and wearable sensors.However,polarized electric charges need to overcome the barrier of graphene sheets to cross over flakes to penetrate into the electrode,as the graphene planes are usually parallel to the electrode surface.By introducing electron-induced perpendicular graphene(EIPG)electrodes incorporated with a stretchable dielectric layer,a flexible and stretchable touch sensor with'in-sheet-chargestransportation'is developed to lower the resistance of carrier movement.The electrode was fabricated with porous nanostructured architecture design to enable wider variety of dielectric constants of only 50-μm-thick Ecoflex layer,leading to fast response time of only 66 ms,as well as high sensitivities of 0.13 kPa-1 below 0.1 kPa and 4.41 MPa-1 above 10 kPa,respectively.Moreover,the capacitance-decrease phenomenon of capacitive sensor is explored to exhibit an object recognition function in one pixel without any other integrated sensor.This not only suggests promising applications of the EIPG electrode in flexible touch sensors but also provides a strategy for internet of things security functions. | Sicheng Chen Yunfei Wang Lei Yang Fouad Karouta Kun Sun | 2020 | Nano-Micro Letters2020，12，10： | 4 |
| 17 | Adaptive Backstepping Control Design for Semi-Active Suspension of Half-Vehicle With Magnetorheological Damper显示文摘This paper investigates the problem of controlling half-vehicle semi-active suspension system involving a magnetorheological(MR)damper.This features a hysteretic behavior that is presently captured through the nonlinear Bouc-Wen model.The control objective is to regulate well the heave and the pitch motions of the chassis despite the road irregularities.The difficulty of the control problem lies in the nonlinearity of the system model,the uncertainty of some of its parameters,and the inaccessibility to measurements of the hysteresis internal state variables.Using Lyapunov control design tools,we design two observers to get online estimates of the hysteresis internal states and a stabilizing adaptive state-feedback regulator.The whole adaptive controller is formally shown to meet the desired control objectives.This theoretical result is confirmed by several simulations demonstrating the supremacy of the latter compared to the skyhook control and passive suspension. | Khalid El Majdoub Fouad Giri Fatima-Zahra Chaoui | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，3： | 4 |
| 18 | Flow cytometric detection of hepatitis C virus antigens in infected peripheral blood leukocytes: Binding and entry显示文摘AIM: We designed two synthetic-core-specific peptides core 1 (C1) and core 2 (C2), and an E1-specific peptide (E1). We produced specific polyclonal antibodies againstthese peptides and used the antibodies for detection of HCV antigens on surface and within infected peripheral blood leukocytes.METHODS: Peripheral blood from a healthy individual who tested negative for HCV RNA was incubated with HCV type 4 infected serum for 1 h and 24 h at 37 ℃. Cells were stained by direct and indirect immunofluorescence and measured by flow cytometry.RESULTS: After 1 h of incubation, antibodies against C1,C2, and E1 detected HCV antigens on the surface of 27%,26% and 73% of monocytes respectively, while 10%, 5% and 9% of lymphocytes were positive with anti-C1, anti-C2 and anti-E1 respectively. Only 1-3% of granulocytes showed positive staining with anti-C1, anti-C2 and anti E1 antibodies. After 24 h of incubation, we found no surface staining with anti-C1, anti-C2 or anti-E1. Direct immunostaining using anti-C2 could not detect intracellular HCV antigens, after 1 h of incubation with the virus, while after 24 h of incubation, 28% of infected cells showed positive staining. Only plus strand RNA was detectable intracellularly as early as 1 h after incubation, and remained detectable throughout 48 h post-infection.Interestingly, minus RNA strand could not be detected after 1 h, but became strongly detectable intracellularly after 24 h post-infection.CONCLUSION: Monocytes and lymphocytes are the preferred target cells for HCV infection in peripheral blood leukocytes. Our specific anti-core and anti-E1 antibodies are valuable reagents for demonstration of HCV cell cycle.Also, HCV is capable of infecting and replicating in peripheral blood mononuclear cells as confirmed by detection of minus strand HCV RNA as well as intracellular staining of core HCV antigen. | Mostafa K El-Awady Ashraf A Tabll El-Rashdy M Redwan Samar Youssef Moataza H Omran Fouad Thakeb Maha El-Demellawy | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 19 | A review of chemical absorption of carbon dioxide for biogas upgrading显示文摘Significant attention has been given to biogas production, purification and upgrading as a renewable and clean fuel supplement. Biogas is a product of an anaerobic digestion process comprising methane, carbon dioxide,and trace amounts of other gases. Biogas purification removes trace gases in biogas for safe utilisation. Biogas upgrading produces methane-rich biogas by removing bulk carbon dioxide from the gas mixture. Several carbon dioxide removal techniques can be applied for biogas upgrading. However, chemical absorption of carbon dioxide for biogas upgrading is of special significance due to its operation at ambient or near ambient temperature and pressure, thus reducing energy consumption. This paper reviews the chemical absorption of carbon dioxide using amine scrubbing, caustic solvent scrubbing, and amino acid salt solution scrubbing. Each of these techniques for biogas upgrading is discussed. The paper concludes that an optimised implementation of the chemical absorption techniques for biogas upgrading requires further research. | Fouad R.H. Abdeen Maizirwan Mel Mohammed Saedi Jami Sany Izan Ihsan Ahmad Faris Ismail | 2016 | Chinese Journal of Chemical Engineering2016，24，6： | 3 |
| 20 | Direct Modulation of the Guard Cell Outward- Rectifying Potassium Channel (CORK) by Abscisic Acid显示文摘 | Amanda Ooi Fouad Lemtiri-Chfieh Aloysius Wong Christoph Gehring | 2017 | Molecular Plant2017，10，11： | 3 |
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