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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Arabidopsis thaliana histone deacetylase1(AtHD1)is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro显示文摘Arabidopsis thaliana 嘘一 deacetylase 1 (AtHD1 或 AtHDA19 ) ,酵母 RPD3 的一个相当或相同的事物,是在植物的许多生理、发展的过程的一个全球管理者。尽管有为在植物基因规定和开发的 AtHD1 的一个角色的基因证据, AtHD1 的生物化学、细胞的性质糟糕被理解。这里,我们在 vivo 报导 AtHD1 的细胞的本地化模式并且嘘在 vitro 的一项 deacetylase 活动。绿荧光灯的蛋白质(GFP ) 的短暂、稳定的表示在洋葱房间标注了 AtHD1 并且分别地,在转基因的 Arabidopsis 的根,种子和叶子表明 AtHD1 在 euchromatic 区域大概在原子核是局部性的并且从核排除。AtHD1 的本地化模式与涉及核形成和 transgenes 的 silencing 并且分别地重复了 DNA 元素的 AtHD2 和 AtHDA6 的那些不同。另外,一 hist 一 deacetylase 活动试金证明在细菌生产的 recombinant AtHD1 示威了一特定嘘在 vitro 的一项 deacetylase 活动。数据建议 AtHD1 是原子蛋白质并且拥有嘘为对植物生长和开发重要的全球 transcriptional 规定负责的一项 deacetylase 活动。 | Paulus M Fong Lu Tian Z Jeffrey Chen | 2006 | Cell Research2006，16，5： | 6 |
| 3 | Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs显示文摘In recent years,several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells.These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells.Interestingly,this notion has also led scientists to question the role of proteins in the secretome produced by cells,tissues or organisms under certain conditions or at a particular time of regenerative therapy.Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs.This could also facilitate the migration of immune,progenitor and stem cells within the body to the site of inflammation.Of these different paracrine factors present within the secretome,researchers have given proper consideration to stromal cell-derived factor-1(SDF1)that plays a vital role in tissue-specific migration of the cells needed for regeneration.Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration.Hence in this study,we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed. | Nazmul Haque Ismail M Fareez Liew Fong Fong Chanchal Mandal Noor Hayaty Abu Kasim Kranthi RajaKacharaju Pratiwi Soesilawati | 2020 | World Journal of Stem Cells2020，12，9： | 3 |
| 4 | Ethnicity and breast cancer in Hawaii:increased survival but continued disparity显示文摘 | Braun KL Fong M Gotay C | 2005 | Ethn Dis2005，15，3： | 1 |
| 5 | International momentum strategies: a stochastic dominance approach显示文摘 | Fong W M Wong W K Lean H H | 2005 | Journal of Financial Markets2005，，8： | 1 |
| 6 | Treatment of ventricu显示文摘 | FONG M W GRAZETTE L CESARIO D | 2011 | Curt Cardiol Rep2011，13，3： | 1 |
| 7 | Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells显示文摘 | Fong CY Chan WK | 2002 | Nat Biotechnol2002，20，9： | 1 |
| 8 | Relative informational efi3ciency of cash, futures, and options markets: The case of an emerging market 显示文摘 | Chiang R Fong W M | 2001 | Journal of Banking & Finance2001，，25： | 1 |
| 9 | Comparative growth behaviour and characterization of stem cells from human Wharton's jelly显示文摘 | Fong CY Richards M Manasi N | | 0，，： | 1 |
| 10 | Amphetamine modulates human incentive processing 显示文摘 | Knutson B Bjork J M Fong G W | 2004 | Neuron2004，43，2： | 1 |
| 11 | Improving the Dynamic Range of a Coherent AM Analog Optical Link Using a Cascaded Linearized Modulators显示文摘 | SABIDO D TABARA M FONG T | 1995 | IEEE Photon?ics Technology Letters1995，7，7： | 1 |
| 12 | In-situ polymerized PLOT columns III: Divinylbenzene copolymers and dimethacrylate homopolymers显示文摘 | SHEN T C FONG M M | 1994 | J Chromatogr Sci1994，32，1： | 1 |
| 13 | Wideband multilayer coaxial-fed microstrip antenna element显示文摘 | Fong K S Puse H F Withers M J | 1985 | Electronics Letters1985，21，11： | 1 |
| 14 | Aberrant promoter methylation of multiple genes in non-small cell lung cancers显示文摘 | ZOCHBAUER-MULLE S FONG K M VIRMANI A K | 2001 | Cancer Res2001，61，1： | 1 |
| 15 | Human fbeders support pro- longed undifferentiated growth of human inner cellmasses and embry- onic stem cells 显示文摘 | Richards M Fong C Y Chan W K | 2002 | Nat Bioteehno12002，20，93： | 1 |
| 16 | Role of the Flt-1 receptor ty-rosine kinase in regulating the assembly of vascular endothelium显示文摘 | Fong GH Rossant J Gertsenstein M | | 0，，： | 1 |
| 17 | Rice by-products: comparative extraction and precipitation of nitrogen from us and spanish bran and germ显示文摘 | Betschart A A Fong R Y Saunders R M | 1977 | Journal of Food Science1977，42，4： | 1 |
| 18 | Embryonic stem cell lines from human blastocysts:somatic differentiation in vitro (vol 18,pg 402,2000)显示文摘 | Reubinoff B E Pera M F Fong C Y | | 0，，05： | 1 |
| 19 | Mining a web citation database for document clustering 显示文摘 | HE Y HUI S C FONG A C M | 2002 | Applied Artificial Intelligence2002，16，： | 1 |
| 20 | Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer显示文摘 | WACKER J ZAREIE M FONG H | 2004 | Nat Struct Mol Biol2004，11，12： | 1 |
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