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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Dendritic cells in cancer immunotherapy显示文摘 | Fong L Engleman EG | | 0，，： | 2 |
| 3 | Retinopathy in diabetes 显示文摘 | FONG DS AIELLO L GARDNER TW | 2004 | Diabetes Care2004，27，： | 1 |
| 4 | Compositional modeling with an equation of state 显示文摘 | Nghiem L X Fong D K Aziz K | 1981 | Society of Petroleum Engineering Journal1981，21，12： | 1 |
| 5 | Dendrfitic cells injected via different routes induce immunity in cancer patients 显示文摘 | Fong L Brockstedt D Benike C | 2002 | J Immunology2002，41，： | 1 |
| 6 | Field evidences of supergene enrichment of the copper deposits of Szechuan, Sikan_g and Yunnan显示文摘 | Fong K L | 1947 | Bulletin of the Geological Society of China1947，27，： | 1 |
| 7 | (2007) : Massive Microbiological Groundwater Contamination Associated with a Waterborne Outbreak in Lake Erie, South Bass Island, Ohio 显示文摘 | Fong T T Mansfield L S Wilson D L | 2007 | Environmental Health Perspective2007，115，6： | 1 |
| 8 | Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells(provenge)plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy显示文摘 | Rini BI Weinberg V Fong L | 2006 | Cancer2006，107，1： | 1 |
| 9 | Molecular and expression analysis of cowpea trypsin inhibitor (CpTI) gene in transgenic Elaeis guineensis Jacq leaves显示文摘 | Ismanizan I Fong S L Ruslan A | 2010 | Aust J Crop Sci2010，4，： | 1 |
| 10 | Treatment of ventricu显示文摘 | FONG M W GRAZETTE L CESARIO D | 2011 | Curt Cardiol Rep2011，13，3： | 1 |
| 11 | Corneal infection in mucosal scarring disorders and Sjogren's syndrome 显示文摘 | Ormerod L D Fong L P Foster C S | 1988 | Am J Ophthalmol1988，105，5： | 1 |
| 12 | Insulin-like Growth Factor 1 Promotes Growth Selectively in fetal sheep in late gestation 显示文摘 | FONG L JULIE A OWENS L | 1996 | AmJPhysiol1996，270，： | 1 |
| 13 | Identification of XAF1 as an antagonist of XIAP anti-Caspase activity显示文摘 | LISTON P FONG W G KELLY N L | 2001 | Nat Cell Biol2001，3，2： | 1 |
| 14 | Effect of prolonged walkingwith backpack loads on trunk muscle activity and fatigue inchildren显示文摘 | HONG Y L LI J X FONG DTP | 2008 | J Electromyogr Kinesiol2008，18，6： | 1 |
| 15 | Palliative Home Nursing In-terventions for People with HIV/AIDS:A Pilot Study显示文摘 | Robinson L Dugger K Fong G | 2006 | JANAC2006，17，3： | 1 |
| 16 | Aspiration of breast abscess under ultrasound guidance: outcome obtained and factors affecting success显示文摘 | Elagili F Abdullah N Fong L | 2007 | Asian J Surg2007，30，1： | 1 |
| 17 | Ahered peptide ligand vaccination with Fh3 ligand expanded dendritic cells for tumor immunotherapy 显示文摘 | Fong L Hou Y Rivas A | 2001 | Proc Natl Acad Sci U S A2001，98，16： | 1 |
| 18 | Aromatase inhibitors from Broussonetia papyrifera 显示文摘 | Lee D Bhat K P L Fong H H S | 2001 | Journal of Natural Products2001，64，： | 1 |
| 19 | Nicotine metabolic profile in man:comparison of cigarette smoking and transdermal nicotine显示文摘 | Jacob P 3rd Fong I | 1994 | J Pharmacol Exp Ther1994，268，1： | 1 |
| 20 | Bending Instability of Electrically Charged Liquid Jets of Polymer Solution in Electrospinning显示文摘 | RENEKER D H YARIN A L FONG H | 2002 | J Appl Phys2002，587，： | 1 |
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