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| 1 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 2 | Study on reservoir operation optimization of Ertan Hydropower Station considering GFS forecasted precipitation显示文摘The medium-term runoff forecasting provided new information for forecast of medium and long term runoff and optimal hydroelectric power generation.According to the actual runoff and hydropower generating characteristics of Ertan Hydropower Station,we studied the decade runoff quantitatively and grade forecast model based on Global Forecasting System(GFS) precipitation forecast information in wet season,then used the posteriori runoff transition probability and measurable probability of runoff forecast to research the uncertain runoff description based on runoff forecast;finally on the basis of the runoff description and the grading forecast accuracy of GFS-based next 10 days'total forecast precipitation,we studied the uncertain optimal operating model of Ertan Hydropower Station considering runoff forecast.The results showed that the runoff forecast considering GFS forecast precipitation and uncertainty has significantly improved the existing runoff description and operating optimization model,and obviously raised the hydropower generation efficiency of Ertan Reservoir. | PENG Yong 1,WANG GuoLi 1,TANG GuoLei 1,ZHOU HuiCheng 1,WANG YaJun 2 & JIAN DePing 2 1 Institute of Water Resources and Flood Control,Dalian University of Technology,Dalian 116023,China 2 Ertan Hydropower Development Co.,Ltd.,Chengdu 610021,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 8 |
| 3 | Comprehensive benefit of flood resources utilization through dynamic successive fuzzy evaluation model: A case study显示文摘Taking the flood resources utilization in Baicheng, Jilin during 2002–2007 as the research background, and based on the entropy weight and multi-level & multi-objective fuzzy optimization theory, this research established a multi-level & semi-constructive index system and dynamic successive evaluation model for comprehensive benefit evaluation of regional flood resources utilization. With the year 2002 as the base year, the analyzing results showed that there existed a close positive correlation between flood utilization volume and its benefits, comprehensive evaluation value and its comparison increment. Within the six successive evaluation years, the comprehensive benefit of 2003 was the best, in which the benefit evaluation increment reached 82.8% whereas the year of 2004 was the worst, in which the increment was only 18.2%. Thus the sustainability and correctness of the evaluation were verified by six years successive evaluation and increment comparison. The analyzing results showed that the economic benefits, ecological benefits and social benefits of flood utilization were remarkable, and that the comprehensive benefit could be improved by increasing flood utilization capacity, which would promote the regional sustainable development as well. The established dynamic successive evaluation provides a stable theoretical basis and technical support for further flood utilization. | FENG Feng1,2, XU ShiGuo1, LIU JianWei1, LIU Dan1,3 & WU Bo4 1 Institute of Water Environment, School of Civil and Hydraulic Engineering, Dalian University of Technology, Dalian 116024, China 2 Yellow River Conservancy Technical Institute, Kaifeng 475003, China 3 College of Water Resources, Shenyang Agricultural University, Shenyang 110161, China 4 Office of Flood Control and Draught Relief in Jilin Province, Changchun 130033, China | 2010 | Science China(Technological Sciences)2010，53，2： | 7 |
| 4 | “92·8”高含沙洪水在黄河下游演进特性分析显示文摘“92.8”洪水位异常高的主要原因:一是前期连续几年枯水,造成河床严重淤积;二是本场洪水边滩淤积,河道过水面积减小。花园口站洪峰流量大于上站的主要原因是:主槽强烈冲刷,水位大幅度下降,漫滩水迅速回归主槽。 | Analytical Group of'August 92'Flood of YRCC | 1993 | 人民黄河1993，15，8： | 6 |
| 5 | 尼古丁透皮贴剂用于手术后镇痛:一项剂量-范围的初步研究显示文摘背景一些动物研究已证实尼古丁在手术后有镇痛作用。然而,尼古丁经鼻喷雾剂在临床试验中得到的结果却好坏参半,这可能与其药代动力学的差异有关,或者受试者中有接触过尼古丁的吸烟者。本初步研究在手术前对非吸烟患者应用尼古丁透皮贴剂,旨在观察其镇痛作用。方法40例接受普外科手术的受试者参加此项随机、双盲、安慰剂对照的前瞻性研究,患者手术后需留院一晚并采用患者自控镇痛。手术前即刻分别给予受试者剂量为0、5、10或15mg的尼古丁透皮贴剂。本研究观察的主要指标为手术后第1小时及此后5天的疼痛程度,使用数字评价量表(NRS)进行评分。次要指标为镇痛药的用量、血流动力学数据、恶心及镇静情况。结果应用尼古丁透皮贴剂的治疗组在手术后第1小时及手术后5天中,疼痛评分均低于使用安慰剂的对照组,手术后第1小时:P=0.003,NRS均值下降1.4,95%CI=0.3~2.6;手术后5天:P=0.03,NRS均值下降1.0,95%CI=0.1-1.9。尼古丁剂量超过5mg时镇痛效果没有明显的提升。治疗组中有镇痛药的使用量减少、恶心增加、心动过速减少和收缩期血压轻度下降的趋势,但无统计学意义。结论剂量为5—15mg的尼古丁透皮贴剂可降低普外科手术后的疼痛评分,但是不能减少阿片类镇痛药的需求及其产生的副作用。 | Daewha Hong Jessamyn Conell-Price Sean Cheng Pamela Flood 王聪(译) 陈卫民(校) | 2010 | 麻醉与镇痛2010，，4： | 2 |
| 6 | 推客带来的厄运:社交媒体如何影响食品安全与风险交流显示文摘一场看来简单的肚子疼,很快就发展成令所有公关头痛的痼疾。直到问题解决.有四个孩子去世.上百个孩子染病。消费者的信任力被严重打击,企业也”名”悬崖边。这就是1992~1993年爆发的大肠杆菌事件,该事件是食品安全问题的领头羊.映射出管理和危机沟通的必要性。 | Matt Raymond Anthony Flood | 2014 | 食品安全导刊2014，，5： | 2 |
| 7 | Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer' s disease 显示文摘 | West MJ Coleman PD Flood DG | 1994 | Lancet1994，344，8925： | 1 |
| 8 | Distributary channel meandering and bifurcation patterns on Amazon deepsea fan as revealed by long-range side-scan sonar(GLORIA)显示文摘 | KOLLA V FLOOD R D | 1983 | Geology1983，11，： | 1 |
| 9 | Isoflurane hyperalgesia is modulated by nicotinic inhibition显示文摘 | Sonner JM Gong D | 2002 | Anesthesiology2002，97，1： | 1 |
| 10 | Product definitions and guidelines for use in specifyinglidar deliverables显示文摘 | Flood M | 2002 | Photogrammetric Engineering and RemoteSensing2002，68，12： | 1 |
| 11 | Transforming growth factor-be- ta 1 in the eerebrospinal fluid of patients with subaraehnoid hemor- rhage: titers derived from exogenous and endogenous sources 显示文摘 | Flood C Akinwunmi J Lagord C | 2001 | Cereb Blood Flow Metab2001，21，2： | 1 |
| 12 | Learning and memory in the SAMP8 mouse显示文摘 | Flood J F Morley J E | 1998 | Neurosci Biobehav Rev1998，22，： | 1 |
| 13 | Phase Ⅲ randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer : An Eastern Cooperative Oncology Group Study 显示文摘 | Burtness B Goldwasser MA Flood W | 2005 | J Clin Oncol2005，23，： | 1 |
| 14 | Alpha4 beta2 neuronal nicotinic acet-ylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha7-type nicotinic acetylcholine receptors are unaffected 显示文摘 | Flood P Ramirez-Latorre J Role L | 1997 | Anesthesiology1997，86，4： | 1 |
| 15 | The role of computerized tomography in the preoperative assessment of chronic suppurative otitis media 显示文摘 | Flood LM | 2003 | Clin Otolaryngol Allied Sci2003，28，5： | 1 |
| 16 | Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hy bridization显示文摘 | Livak KJ Flood SJ Marmaro J | 1995 | PCR Methods Appl1995，4，6： | 1 |
| 17 | Geochemical constrains on the dep-ositional setting of Palaeozoic cherts from the New Englandorogen,NSW,eastern Australia显示文摘 | Aitchison J C Flood P G | 1990 | Marine Geology1990，94，： | 1 |
| 18 | A modified surgical approach for parapharyngeal space tumors: Use of inverted 'L' osteotomy 显示文摘 | Flood Dg Hislop WS | 1991 | Br J Oral Maxillofac Sueg1991，29，： | 1 |
| 19 | Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization显示文摘 | Livak KJ Flood SJ Marmaro J | 1995 | PCR Methods Appl1995，4，6： | 1 |
| 20 | Dietary fiber and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort显示文摘 | MAI V FLOOD A PETER U | 2003 | Int J Epidemiol2003，32，： | 1 |
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