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| 1 | Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia显示文摘AIM To evaluate factors associated with Clostridium difficile infection (CDI) and outcomes of CDI in the myelodysplastic syndrome(MDS) and acute myeloid leukemia (AML) population.METHODS After IRB approval,all MDS/AML patients hospitalized at the University of Maryland Greenebaum Comprehensive Cancer Center between August 2011 and December 2013 were identified.Medical charts were reviewed for demographics,clinical information,development of CDI,complications of CDI,and mortality.Patients with CDI,defined as having a positive stool PCR done for clinical suspicion of CDI,were compared to those without CDI in order to identify predictors of disease.A t-test was used for comparison of continuous variables and chisquare or Fisher's exact tests were used for categorical variables,as appropriate.RESULTS Two hundred and twenty-three patients (60.1% male,mean age 61.3 years,13% MDS,87% AML) had 594 unique hospitalizations during the study period.Thirtyfour patients (15.2%) were diagnosed with CDI.Factors significantly associated with CDI included lower albumin at time of hospitalization (P < 0.0001),prior diagnosis of CDI (P < 0.0001),receipt of cytarabine-based chemotherapy (P = 0.015),total days of neutropenia (P = 0.014),and total days of hospitalization (P = 0.005).Gender (P = 0.10),age (P = 0.77),proton-pump inhibitor use (P = 0.73),receipt of antibiotics (P = 0.66),and receipt of DNA hypomethylating agent-based chemotherapy (P = 0.92) were not significantly associated with CDI.CONCLUSION CDI is common in the MDS/AML population.Factors significantly associated with CDI in this population include low albumin,prior CDI,use of cytarabine-based chemotherapy,and prolonged neutropenia.In this study,we have identified a subset of patients in which prophylaxis studies could be targeted. | Kamini Shah Bryan F Curtin Christopher Chu Daniel Hwang Mark H Flasar Erik von Rosenvinge | 2017 | World Journal of Clinical Oncology2017，8，5： | 3 |
| 2 | Acute abdominal pain 显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin North Am2006，90，3： | 1 |
| 3 | Acute abdominal pain显示文摘 | Flasar MH Goldberg E | 2006 | Medical Clinics of North America2006，33，3： | 1 |
| 4 | Acute abdominal pain 显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin Am2006，90，3： | 1 |
| 5 | Atute abdominal pain显示文摘 | Flasar M H Goldberg E | 2006 | Med clin NorthAM2006，90，3： | 1 |
| 6 | Acute abdominal pain显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin North Am2006，90，3： | 1 |
| 7 | Acute abdominal pain 显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin North Am2006，90，： | 1 |
| 8 | Aeute abdominal pain显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin Am2006，90，3： | 1 |
| 9 | Acute abdominal pain显示文摘 | FLASAR MH GOLEBERG E | | 0，，03： | 1 |
| 10 | Acute abdominal pain显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin N Am2006，90，3： | 1 |
| 11 | Clostridium difficile-associated disease:Adherence with current guidelines at a tertiary medical center显示文摘AIM:To assess adherence with the the Society for Healthcare Epidemiology of America(SHEA)/the Infectious Diseases Society of America(IDSA)guidelines for management of Clostridium difficile(C.difficile)-associated disease(CDAD)at a tertiary medical center.METHODS:All positive C.difficile stool toxin assays in adults between May 2010 and May 2011 at the University of Maryland Medical Center were identified.CDAD episodes were classified as guideline adherent or nonadherent and these two groups were compared to determine demographic and clinical factors predictive of adherence.Logistic regression analysis was performed to assess the effect of multiple predictors on guideline adherence.RESULTS:320 positive C.difficile stool tests were identified in 290 patients.Stratified by disease severity criteria set forth by the SHEA/IDSA guidelines,42.2%of cases were mild-moderate,48.1%severe,and 9.7%severe-complicated.Full adherence with the guidelines was observed in only 43.4%of cases.Adherence was65.9%for mild-moderate CDAD,which was significantly better than in severe cases(25.3%)or severe-complicated cases(35.5%)(P<0.001).There was no difference in demographics,hospitalization,ICU exposure,recurrence or 30-d mortality between adherent and non-adherent groups.A multivariate model revealed significantly decreased adherence for severe or severecomplicated episodes(OR=0.18,95%CI:0.11-0.30)and recurrent episodes(OR=0.46,95%CI:0.23-0.95).CONCLUSION:Overall adherence with the SHEA/IDSA guidelines for management of CDAD at a tertiary medical center was poor;this was most pronounced in severe,severe-complicated and recurrent cases.Educational interventions aimed at improving guideline adherence are warranted. | Bryan F Curtin Yousef Zarbalian Mark H Flasar Erik von Rosenvinge | 2013 | World Journal of Gastroenterology2013，19，46： | 1 |
| 12 | Acute abdominal pain 显示文摘 | Flasar MH Goldberg E | 2006 | Med Clin North Am2006，90，3： | 1 |
| 13 | Anti-tumor necrosis factor therapy is associated with infections after abdominal surgery in Crohn's dis- ease patients显示文摘 | Syed A Cross RK Flasar MH | 2013 | Am J Gastroenterol2013，108，4： | 1 |
| 14 | Fracture behaviour ofAl2O3/SiC nanocornposite ceramics after crack healing treatment 显示文摘 | CHLUP Zdenek FLASAR Petr KOTOJI Ando | 2008 | J Eur Ceram Soc2008，28，5： | 1 |
| 15 | 查看详情显示文摘 | Hanel R Conrath B Flasar F.M Kunde V. Maguire W. Pearl J. Pirraglia J. Samuelson R. Herath L. Allison M. Cruikshank D. Gautier D. Gierasch P. Horn L. Koppany R. Ponnamperuma C | | 0，，： | 1 |
| 16 | Acute abdominal pain显示文摘 | Flasar M H Goldberg E | 2006 | MedClin North Am2006，90，： | 1 |
| 17 | Acute Abdominal Pain显示文摘 | Mark H. Flasar Eric Goldberg | 2006 | Medical Clinics of North America2006，，3： | 1 |
| 18 | 最佳的机床设备是实现涡轮机合理化制造的前提条件显示文摘自从实施弃核计划以来,替代性能源政策越来越引起工业生产领域的重视。对用于水力发电的涡轮机的制造也成为一个话题。这种要求较高的部件的生产是否具有经济性,这在很大程度上将取决于生产技术装备。 | Jaroslav Flasar | 2012 | 现代制造2012，，23： | 0 |
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