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| 1 | 城市导视系统设计显示文摘城市导视系统设计是指一个完整的城市指示系统,包括行政交通导视系统、商业导视系统、文化旅游导视系统等。城市导视系统系统是城市形象和城市功能的重要组成部分,其合理设计和运用不仅可以使城市生活更加便利,而且也是使城市具有魅力的形象塑造。本文对国内国际上的优秀案例进行分析,并就城市导视系统设计的功能、审美特征以及实施方法进行了探讨。 | City design Institute,Central Academy of Fine Art,Beijing 100009) | 2004 | 城市发展研究2004，11，1： | 24 |
| 2 | Neuroprotection of aucubin in primary diabetic encephalopathy显示文摘Hippocampal neuronal apoptosis accompanied by impairment of cognitive function occurs in primary diabetic encephalopathy. In this study, we investigated the neuroprotective mechanism of the iridoid glycoside, aucubin, using rats (n=8). Diabetes mellitus was induced in the rats by intraperitoneal (i.p.) injection of streptozotocin (60 mg/kg body weight). After 65 d, half of the DM rats were administered aucubin (5 mg/kg; i.p.) for 15 d, yielding treatment DM+A. A third group of rats received no strepto- zotocin or aucibin, and served as controls (CON). Encephalopathy was assessed using Y-maze be- havioral testing. Rats were euthanized on Day 87, and hippocampi were excised for visual (light and transmission electron microscopic) and immunochemical (Western blot; immunohistochemical) as- sessments of the CA1 subfield for apoptosis and expression of regulatory proteins Bcl-2 and Bax. Treatment responses to all the parameters examined (body weight, plasma glucose, Y-maze error rates, pyramidal cell ultrastructure, proportions of apoptotic cells, levels of expression of Bcl-2 and Bax, and survivability of neuronal cells) were identical: there were highly significant differences between DM and CON groups (P<0.001), but the effects were significantly moderated (P<0.01) in DM+A compared with DM. These findings confirm the association of apoptosis with the encephalopathic effects of diabetes mellitus, and suggest a major role of the expression levels of Bcl-2 and Bax in the regulation of apop- totic cell death. All of the results suggest that aucubin could effectively inhibit apoptosis by modulating the expressions of Bcl-2 and Bax genes. | XUE HongYu1, JIN LiJi1,2, JIN Lei1, ZHANG Peng1, LI DanQing4, XIA YanQiu1, LU YaNan1 & XU YongPing1,3 1 Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China 2 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China 3 Dalian SEM Bioengineer and Biotech Ltd., Dalian 116024, China 4 The Second Affiliated Hospital, Dalian Medical University, Dalian 116024, China | 2008 | Science China(Life Sciences)2008，51，6： | 22 |
| 3 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 4 | Isolation and Purification of Isoaloeresin D and Aloin from Aloe vera by High-speed Counter-current Chromatography显示文摘Objective To develop an efficient method to isolate and purify the main components isoaloeresin D and aloin from Aloe vera for its industrial production.Methods High-speed counter-current chromatography was used to isolate isoaloeresin D and aloin in a one-step separation from dried crude extract of A.vera.The biphasic solvent system composed of hexane-ethyl acetate-acetone-water(0.2:5:1.5:5) was used at a flow rate of 1.0 mL/min,while the lipophilic phase was selected as the mobile phase and the apparatus was rotated at 840 r/min.The effluent was detected at 254 nm.Results Isoaloeresin D(53.1 mg) and aloin(106.9 mg) were separated from the crude extract(384.7 mg) with the purities of 98.6% and 99.5%,respectively.Conclusion HSCCC is a powerful technique for isolation and separation of chemical composition from aloe. | WAN Jin-zhi1,CHEN Xin-xia1,QIU Chun-mei1,LIN Xiang-cheng2 1.Laboratory for Pharmaceutical Analysis and Quality Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China 2.Institute of Fine Chemicals and Synthetic Drugs,Sun Yat-sen University,Guangzhou 510006,China | 2010 | Chinese Herbal Medicines2010，2，2： | 12 |
| 5 | DISCUSSING ON SOLID ABRASIVE LAPPING PATH显示文摘DISCUSSINGONSOLIDABRASIVELAPPINGPATHYangJiandong,WenXuehengChangchunInstituteofOpticsandFineMechanicsZhuYanqiu,WangLijiangJil... | Yang Jiandong ,Wen XuehengChangchun Institute of Optics and Fine MechanicsZhu Yanqiu, Wang Lijiang Jilin University of Technology | 1997 | Chinese Journal of Mechanical Engineering1997，10，2： | 11 |
| 6 | Static Theory for Planar Ferromagnets and Antiferromagnets | Feng Bo HANG Fang Hua LIN Courant Institute, 251 Mercer Street. New York. NY 10012, USA Dept. of Math, Princeton University, Fine Hall. Washington Road, Princeton, NJ 08544 USA. | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 8 |
| 7 | The non-destructive analysis of ancient jade artifacts unearthed from the Liangzhu sites at Yuhang,Zhejiang显示文摘Samples of the jade artifacts unearthed from the Liangzhu sites at Yuhang (Fanshan,Yaoshan, Huiguanshan and Tangshan) of Zhejiang province were described. The chemical composition, phase and jade structure of a hundred and more intact samples were analyzed by the non-destructive techniques of PIXE, XRD and laser Raman spectroscopy. Results showed that the minerals of the jade artifacts mostly belonged to tremolite and tremolite-actinolite. Relationship of the civilization development in the Neolithic age and the application of tremolite type mineral in jade artifacts was discussed. The contents of rare and trace elements in tremolite jade artfacts and in mineral samples were measured for the first time. The possible mineral sources of these tremolite type jade artifacts were discussed. | GAN FuXi1,3, CAO JingYan2, CHENG HuanSheng3, Gu DongHong1, RUI GuoYao2, FANG XiangMing2, DONG JunQing1 & ZHAO HongXia1 1Scientific Archeology Center, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China 2 Research Institute of Cultural Relics and Archeology of Zhejiang, Hangzhou 310014, China 3 Fudan University, Shanghai 200433, China | 2010 | Science China(Technological Sciences)2010，53，12： | 8 |
| 8 | 矩形平面磁控溅射装置薄膜沉积仿真显示文摘薄膜厚度沿矩形靶长度方向分布的均匀度是衡量矩形平面磁控溅射装置镀膜质量的重要指标。为了分析气压和靶基板间距对该指标的影响,本文采用Monte Carlo方法,在假设靶材沿跑道均匀刻蚀的前提下,对靶材原子沉积过程进行了计算机仿真。模型假设靶材原子出射能量满足Thompson分布,出射角度以余弦定律处理;假设背景气体速度为麦克斯韦分布,并采用舍选法对各个速度分量进行了抽样;应用可变硬球模型对碰撞过程进行了处理。通过仿真发现,随着气压增大,尽管薄膜的均匀度越好,但是靶材原子到达基板的能量会降低;而靶与基板间距越大,薄膜的均匀度和靶材原子到达基板的能量都会降低。另外,通过对矩形靶端部磁场改进,可以削弱靶材的反常刻蚀现象,在提高靶材利用率的同时,可以有效提高薄膜均匀度。 | 邱清泉 励庆孚 苏静静 Jiao Yu Finely Jim | 2008 | 真空科学与技术学报2008，28，3： | 8 |
| 9 | Binary Laser Direct Writing System and Its Applications显示文摘A new laser direct writing system is introduced and the potential application of the diffractive optical elements (DOE’s) fabricated by applying laser direct writing system are presented. The fabrication techniques by applying the laser direct writing are developed. Experimental results have been obtained by applying laser direct writing machine with line width of 5μm and 10μm. | LI Feng you,LU Zhen wu,XIE Yong jun, ZHANG Dian wen (Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130022, China) | 2001 | 光学精密工程2001，9，5： | 7 |
| 10 | Effect of illumination intensity and light application time on secondary organic aerosol formation from the photooxidation of α-pinene显示文摘Secondary organic aerosol (SOA) formation from hydroxyl radical (OH.) initiated photooxidation of α-pinene was investigated in a home-made smog chamber. The size distribution of SOA particles was measured using aerodynamic particle sizer spectrometer. The effects of illumination intensity and light application time on SOA formation for α-pinene were evaluated. Experimental results show that the concentration of SOA particles increased significantly with an increasing of illumination intensity, and the light application time, the concentration, and the size of SOA particles were also increased. In addition, the factors influencing the formation of SOA were discussed. In addition, this article compared the effect of α-pinene with that of toluene, and discussed the contribution of α-pinene to SOA formation. | LIU Xianyun, ZHANG Weijun, HUANG Mingqiang, WANG Zhenya, HAO Liqing, ZHAO Wenwu Laboratory of Environment Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences,Hefei 230031, China. | 2009 | Journal of Environmental Sciences2009，21，4： | 7 |
| 11 | Improvement of water resistance of long afterglow SrAl_2O_4: Dy, Eu phosphor by coating with SiO_2 film显示文摘The long afterglow SrAl2O4:Dy,Eu phosphor is liable to hydrolyze in water with deterioration of the luminescent property. SrAl2O4:Dy,Eu phosphors were therefore heated at 60-90℃ in TEOS sol to form a surface gel and then heat-treated at 400℃ to obtain SiO2 coated phosphors. Observation by Transmission Electron Microscope (TEM) and X-ray photoelectron spectroscopy (XPS) shows that a thin silica film forms on the surface of the phosphors. The coating procedure can be illustrated by a four-step process and the transparent silica film can suppress the hydrolysis process, so that the luminescent properties of the phosphors are unimpaired or even better. | ZHANG Junying, CHEN Qingming, LIN Yuanhua, and ZHANG ZhongtaiState Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University,Beijing 100084, China | 2002 | Rare Metals2002，21，2： | 7 |
| 12 | 矩形平面直流磁控溅射装置端部磁场分析显示文摘矩形平面直流磁控溅射装置在运行过程中,由于端部区域磁场弱于直道区域磁场,在靶表面对角线位置上容易出现反常刻蚀.通过对这种现象进行分析,该文对反常刻蚀的发生机理提出了新的观点,认为反常刻蚀的发生是由于电子由弱磁场区域向强磁场区域漂移的过程中,电子距靶表面的距离不能够随磁场变化而迅速改变,存在较长的过渡状态.进一步发现在磁体弯道区域沿圆周方向磁场分量的存在是导致弯道区域刻蚀跑道压缩以及跑道内侧刻蚀较快的重要因素.该文研究了不同的磁体初始设计结构对磁场的影响,通过对现有磁体磁场的三维计算分析,提出了磁场的改进原则,并对具体的磁场改进措施进行了研究.通过对现有不同磁场校正方法的比较,提出了一种应用铁块和永磁块对装置端部区域磁场进行校正的新方法.通过对改进后装置的磁场分布进行计算,该文提出的改进措施可以把沿跑道磁场的均匀度控制在5%左右,并且可以削弱沿圆周方向的磁场分量. | 邱清泉 励庆孚 YU Jiao FINELY Jim | 2006 | 中国电机工程学报2006，26，z1： | 6 |
| 13 | A novel synthetic route for LiFePO_4/C cathode materials by addition of starch for lithium-ion batteries显示文摘LiFePO4/Carbon composite cathode material was prepared using starch as carbon source by spray-pelleting and subsequent pyrolysis in N2. The samples were characterized by XRD, SEM, Raman, and their electrochemical performance was investigated in terms of cycling behavior. There has a special micro-morphology via the process, which is favorable to electrochemical properties. The discharge capacity of the LiFePO4.C composite was 170 mAh g-1, equal to the theoretical specific capacity at 0.1 C rate. At 4 C current density, the specific capacity was about 80 mAh g-1, which can satisfy for transportation applications if having a more flat discharge flat. | Shao Hua Luo, Zi Long Tang, Jun Biao Lu, Zhong Tai Zhang State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2007 | Chinese Chemical Letters2007，18，2： | 5 |
| 14 | Microstructure and oxygen storage capacity of Sr-modified Pt/CeO_2-ZrO_2 catalysts | Rui Ran a,Jun Fan b,Duan Weng a,a State Key Lab of New Ceramic and Fine Processing,Department of Materials Science and Engineering,Tsinghua University,Beijing 100084,China b The Administrative Centre for China’s Agenda 21,Beijing 100038,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 5 |
| 15 | 半乳甘露聚糖试验诊断侵袭性曲霉病的评价——一项荟萃分析显示文摘侵袭性曲霉病(invasive aspergillosis,IA)多见于免疫缺陷患者,据报道在异体造血干细胞移植受者中IA发生率为8%~15%,在实体器官移植受者中为5%~15%,且病死率可高达30%~70%。然而IA的早期诊断仍是临床上的难题,因为确诊标准需要组织活检镜检或培养阳性,但真菌培养阳性率低且费时,而组织活检可行性差。目前已研究了很多非培养检测方法,包括检测真菌特异抗原、真菌代谢产物或真菌DNA,如抗原β-葡聚糖(存在于大部分真菌,除外隐球菌和接合菌)、半乳甘露聚糖(galactomannan,GM);GM大部分存在于曲霉,是曲霉生长过程中释放的细胞壁多糖成分,还存在于青霉)等具有很好的发展前景。 | Pferffer CD Fine JP Safdar N 唐晓丹 | 2007 | 中国感染与化疗杂志2007，7，1： | 5 |
| 16 | 平面直流磁控溅射放电等离子体模拟研究进展显示文摘放电等离子模拟是平面直流磁控溅射装置系统仿真的一个重要的子过程。本文根据模型的种类,求解问题的维数以及自洽性对磁控放电等离子体模拟方法进行了分类,并通过介绍不同种类的仿真模型,诸如动力学模型,流体模型,粒子模型,混合模型以及简化模型,根据平面直流磁控溅射放电的特殊性,对这些模型在该装置等离子模拟中的适用性进行了分析。兼顾问题求解的速度和质量,本文认为二维自洽粒子模拟与三维非自洽粒子模拟是目前需要重点研究的两种方法。最后作者对磁控放电等离子体模拟的进一步发展进行了展望。 | 邱清泉 励庆孚 苏静静 Jiao Yu Finely Jim | 2007 | 真空科学与技术学报2007，27，6： | 5 |
| 17 | Adaptive Backstepping Sliding Mode Trajectory Tracking Control for a Quad-rotor显示文摘A quad-rotor aircraft is an under-actuated,strongly coupled nonlinear system with parameter uncertainty and un-modeled disturbance.In order to make the aircraft track the desired trajectory,a nested double-loops control system is adopted in this paper.A position error proportional-derivative(PD) controller is designed as the outer-loop controller based on the coupling action between rotational and translational movement,and an adaptive backstepping sliding mode control algorithm is used to stabilize the attitude.Finally,both the numerical simulation and prototype experiment are utilized to demonstrate the effectiveness of the proposed control system. | Xun Gong 1 Zhi-Cheng Hou 1 Chang-Jun Zhao 2 Yue Bai 2 Yan-Tao Tian 1 1 School of Telecommunication Engineering,Jilin University,Changchun 130025,China 2 Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun 130080,China | 2012 | International Journal of Automation and computing2012，9，5： | 5 |
| 18 | Microstructures and characteristics of deep trap levels in ZnO varistors doped with Y_2O_3显示文摘In this paper discussions on ZnO based varistor ceramics doped with different ratios of Y2O3 are presented.Analysis on the phase and microstructures of the samples indicates that an additional phase is detected in the samples doped with Y2O3,and the average grain size of the specimens decreases from about 9.2μm to 4.5μm,with an increase in the addition of Y2O3 from 0 mol%to 3 mol%.The corresponding varistor’s voltage gradient markedly increases from 462 V/mm to 2340 V/mm,while the nonlinear coefficient decreases from 22.3 to 11.5,respectively.Furthermore,the characteristics of deep trap levels in these ZnO samples are investigated by measuring their dielectric spectroscopies.The trap energy level and capture cross section evaluated by relaxation peak of the Cole-Cole plot vary slightly as the addition of Y2O3 increases.These traps may be ascribed to the intrinsic defects of ZnO lattice. | LIU Jun 1 ,HU Jun 1 ,HE JinLiang 1 ,LIN YuanHua 2 &LONG WangCheng 1 1State Key Laboratory of Power Systems,Department of Electrical Engineering,Tsinghua University,Beijing 100084,China 2State Key Laboratory of New Ceramics and Fine Processing,Department of Material Science and Engineering,Tsinghua University, Beijing 100084,China | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 19 | Generation of high affinity human single-hain antibody against PreSl of hepatitis B virus from immune phage-display antibody library显示文摘BACKGROUND: A single-chain antibody ( ScFv) phage display library was created by cloning antigen-binding re- gions of VH (variable domain) and VL gene repertoires as fusion proteins with a minor coat protein of filamentous phage, from which high affinity completely humanized ScFv against PreS1 of hepatitis B virus could be screened and characterized. METHODS: A combinatorial library of phage-display hu- man ScFv genes, which were derived from peripheral blood lymphocytes immunized by peptide PreS1 in vitro, was constructed. The library contained 7 × 108 clones. RESULTS: After 3 rounds panning, a high affinity (K = 10-7-10-8 mol/L) ScFv specific to PreS1 was obtained. Sequence analysis showed that the VH belonged to the VH4 family and Vλ to Vλ4. CONCLUSIONS: The described ScFv may provide a more satisfactory therapy. This application further illustrates that the method of in vitro antigen stimulation is expeditious for the source of human immune antibody library. | Zhi-Chao Zhang, Xue-Jun Hu and Qing Yang Dalian, China State Key Laboratory of Fine Chemicals, Dalian Uni- versity of Technology, Dalian 116012, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 5 |
| 20 | Some considerations of organic materials for high density optical disk data storage显示文摘The application possibilities of organic materials for high density optical disk data storage are discussed. Several points, such as physical and chemical stabilities, wavelength match and reversible property changes, which should be taken into consideration, are presented. | GAN FuxiShanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China | 2000 | Chinese Science Bulletin2000，45，6： | 5 |
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