|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 3 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 4 | In vitro antibacterial effect of aqueous and ethanolic Moringa leaf extracts显示文摘Objective:To evaluate the antibacterial effect of aqueous and ethanolic moringa leaf extracts (Moringa oleifera) on the growth of gram-positive and negative bacteria.Methods:Paper disks were soaked with 100,200,300 and 400μL of extract at 20 g/180mL and 10 g/190 mL.All extracts were tested against Escherichia coli(ATCC25922),Staphylococcus aureus(ATCC25923),Vibrio parahaemolyticus,Enterococcus faecalis(ATCC29212),Pseudomonas aeruginosa(ATCC27853), Salmonella enteritidis(IH) and Aeromonas caviae.The susceptibility tests were performed using the modified disk diffusion method.Results:The strains E.coli,P.aeruginosa and S.enteritidis (IH) were resistant to all treatments.In general,disks with 400μL extract were the most efficient against S.aureus,V.parahaemolyticus,E.faecalis and A.caviae.Conclusions:The study indicates a promising potential for aqueous and ethanolic Moringa leaf extracts as alternative treatment of infections caused by the tested strains. | Jackson Rafael Oliveira Peixoto Giselle Cristina Silva Renata Albuquerque Costa Joseires Lira de Sousa Fontenelle Gustavo Hitzschky Fernandes Vieira Antonio Adauto Fonteles Filho Regine Helena Silva dos Fernandes Vieira | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 7 |
| 5 | Assessing the inter-annual variability of separation distances around odour sources to protect the residents from odour annoyance显示文摘In recent years, there has been a growing concern about potential impacts on public health and wellbeing due to exposure to environmental odour. Separation distances between odour-emitting sources and residential areas can be calculated using dispersion models, as a means of protecting the neighbourhood from odour annoyance. This study investigates the suitability of using one single year of meteorological input data to calculate reliable direction-dependent separation distances. Accordingly, we assessed and quantified the inter-annual variability of separation distances at two sites with different meteorological conditions, one in Brazil and the other in Austria. A 5-year dataset of hourly meteorological observations was used for each site. Two odour impact criteria set in current regulations were selected to explore their effect on the separation distances. The coefficient of variation was used as a statistical measure to characterise the amount of annual variation. Overall,for all scenarios, the separation distances had a low degree of inter-annual variability(mean coefficient of variation values from 8% to 21%). Reasonable agreements from year to year were therefore observed at the two sites under investigation, showing that one year of meteorological data is a good compromise to achieve reliable accuracy. This finding can provide a more cost-effective solution to calculate separation distances in the vicinity of odour sources. | Marlon Brancher Martin Piringer Davide Franco Paulo Belli Filho Henrique De Melo Lisboa Gunther Schauberger | 2019 | Journal of Environmental Sciences2019，31，5： | 6 |
| 6 | 巴西皮拉西卡巴地区垂直上流湿地中营养物的去除显示文摘垂直上流湿地显示了很高的营养物去除效率。本文研究了废水中营养物(氮和磷)在巴西皮拉西卡巴地区一处垂直上流湿地系统中的去除。结果显示,磷酸盐、硝酸盐和氨的浓度去除率分别为93%、78%和50%。在具有很高吸附表面积的表层土壤观察到了磷酸盐的有效去除。低负荷的硝酸盐可以通过植物吸收和反硝化作用被有效地去除。氨的去除率与浓度有关,且随着入流浓度的升高而下降。通过对湿地底床的空间采样发现其处理效率并不均衡。以土壤改良剂或动物饲料的方式进行营养循环利用的可能性是上述垂直上流湿地系统的重要特征之一。 | Neda Farahbakhshazad Gregory M.Morrison Eneas Salati Filho 陶湛 | 2000 | AMBIO-人类环境杂志2000，29，2： | 6 |
| 7 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 8 | Posterior partially edentulous jaws, planning a rehabilitation with dental implants显示文摘AIM: To discuss important characteristics of the useof dental implants in posterior quadrants and the rehabilitation planning. METHODS: An electronic search of English articles was conducted on MEDLINE(PubM ed) from 1990 up to the period of March 2014. The key terms were dental implants and posterior jaws, dental implants/treatment planning and posterior maxilla, and dental implants/treatment planning and posterior mandible. No exclusion criteria were used for the initial search. Clinical trials, randomized and non randomized studies, classical and comparative studies, multicenter studies, in vitro and in vivo studies, case reports, longitudinal studies and reviews of the literature were included in this review. RESULTS: One hundred and fifty-two articles met the inclusion criteria of treatment planning of dental implants in posterior jaw and were read in their entirety. The selected articles were categorized with respect to their context on space for restoration, anatomic considerations(bone quantity and density), radiographic techniques, implant selection(number, position, diameter and surface), tilted and pterygoid implants, short implants, occlusal considerations, and success rates of implants placed in the posterior region. The results derived from the review process were described under several different topic headings to give readers a clear overview of the literature. In general, it was observed that the use of dental implants in posterior region requires a careful treatment plan. It is important that the practitioner has knowledge about the theme to evaluate the treatment parameters. CONCLUSION: The use of implants to restore the posterior arch presents many challenges and requires a detailed treatment planning. | Douglas R Monteiro Emily V F Silva Eduardo P Pellizzer Osvaldo Magro Filho Marcelo C Goiato | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 9 | Thermal and structural properties of Nd2O3-doped calcium boroaluminate glasses显示文摘Nd^(3+) doped CaO-Al_2O-B_2O_3-CaF_2 glasses were prepared by conventional melt-quenching technique,and their structural and thermal properties were studied.The amorphous nature of these samples was confirmed by X-ray diffraction(XRD).The measured density showed an increase with Nd_2O_3 doping,at the expense of CaO.Raman spectra presented changes with addition of Nd_2O_3,which indicated that the network structure of the glasses studied presented various borate groups,such as tetraborates,metaborates,ortho-borates and pyroborates units.The N_4 values calculated from FTIR spectra revealed that incorporation of Nd_2O_3 into glass network converted the structural units from BO_4 to BO_3.From the analysis of DTA curves,we verified that Tg increased with the addition of Nd_2O_3;it was similar to the behavior caused by modifier oxides in the structure of borate glasses.Besides that,the calculated glass stability Tx–Tg for doped samples presented a decrease if compared to the undoped glass.Specific heat and thermal conductivity did not present significant changes with Nd_2O_3 concentration,up to 2.30 mol.%.The results of density,DTA,Raman and FTIR reinforced the idea that Nd_2O_3 acted as network modifier. | J.D.M.Dias G.H.A.Melo T.A.Lodi J.O.Carvalho P.F.Facanha Filho M.J.Barboza A.Steimacher F.Pedrochi | 2016 | Journal of Rare Earths2016，34，5： | 6 |
| 10 | 应用增爬群改善大雨条件下800 kV叠锥型支柱绝缘子的雨闪性能(英文)显示文摘Studies based on AC high voltage tests have been done at Cepel to investigate the performance of 800 kV busbar insulators under heavy wetting conditions.Insulators were tested which are now used on site and also with different configurations of booster sheds.Images recorded by ultra-violet(UV) camera were used to help the investigations on the effectiveness of booster sheds.By comparing UV images of the insulator being stressed with high voltage under heavy artificial rain,with and without booster sheds,it was possible to observe how significant the reduction on the flashover formation process was when booster sheds were used.The effectiveness of booster sheds was also quantified by determining the disruptive discharge of the insulator with and without them.The results of these studies can also be considered as contribution to national and international standard technical committees to improving the standardized procedure for tests on ultra high voltage(UHV) insulators under heavy rain.Subjects such as the clear definition of relevant UHV test procedure and test arrangements,including the use of UV camera,have to be taken into account. | Orsino Oliveira Filho José Antonio Cardoso Darcy Ramalho de Mello Rogério Magalhes de Azevedo Sylvia G Carvalho | 2011 | 高电压技术2011，37，11： | 5 |
| 11 | Landslide susceptibility mapping using the infinite slope,SHALSTAB,SINMAP,and TRIGRS models in Serra do Mar,Brazil显示文摘Slope failure triggered by heavy rainfall is very common in tropical and subtropical regions and a cause of major social and economic damage.Landslide susceptibility maps can be generated using geographical information systems(GIS)and limit equilibrium slope stability models coupled or not to hydrological equations.This study investigated the efficacy of four models used for slope stability analysis in predicting landslide-susceptible areas in a GIS environment.The selected models are the infinite slope,the shallow slope stability model(SHALSTAB),the stability index mapping(SINMAP),and the transient rainfall infiltration and grid-based regional slope-stability(TRIGRS).For comparisons,the authors(a)included the infinite slope equation in all models,(b)clearly defined input parameters and failure triggering mechanisms for each simulation(soil depth,water table height,rainfall intensity),(c)determined appropriate values for each model to obtain stability levels that represented similar hydrogeotechnical conditions,and(d)considered upper-third areas of landslide scars to estimate the reliability of susceptibility maps using validation indices.An intense rainfall event occurred in Serra do Mar,Brazil in January 2014 triggered hundreds of landslides and was used for back analysis and evaluation of the slope stability analysis models.When rainfall intensity is not considered,the four models produced very similar results.The most reliable landslide susceptibility map was generated using TRIGRS and considering the granite residual granite soils geological-geotechnical unit,subjected to a rainfall intensity of 210 mm for 2 h under unsaturated conditions. | Thiago Machado do PINHO Oswaldo AUGUSTO FILHO | 2022 | Journal of Mountain Science2022，19，4： | 5 |
| 12 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 13 | Application of Molecular Distillation Process to Extend the True Boiling Point Curve of Petroleum Residues 400 ℃ +显示文摘 | Erica Roberta Lovo da Rocha Melina Savioli Lopes Maria Regina Wolf Maciel Rubens Maciel Filho Cesar Benedito Batistella Lilian Carmem Medina | 2011 | Journal of Chemistry and Chemical Engineering2011，5，2： | 4 |
| 14 | Green tea polyphenols inhibit testosterone production in rat Leydig cells显示文摘这研究调查了绿茶摘录(GTE ) 和它的多酚的尖锐效果成分,(-)-epigallocatechin-3-gallate (EGCG ) 和(-)-epicatechin (EC ) ,在由在 vitro 的老鼠 Leydig 房间的基础、刺激的睾丸激素生产上。在一个 Percoll 坡度净化的 Leydig 房间与 GTE, EGCG 或 EC 和睾丸激素先锋 androstenedione 为 3 h 被孵化,当面或任何一个蛋白质 kinase A (PKA ) 的缺席或蛋白质 kinase C (PKC ) 使活跃之物。效果的可逆性被 pretreating 房间与 GTE 或 EGCG 为 15 min 学习,允许他们为 1 h 恢复并且为有人的 chorionic 的 2 h 质问他们 gonadotropin (hCG ) , luteinizing 荷尔蒙释放荷尔蒙(LHRH ) , 22 (R)-hydroxycholesterol 或 androstenedione。GTE 和 EGCG,然而并非 EC,禁止了基础、刺激 kinase 的睾丸激素生产。在预告的处理条件下面, hCG/LHRH-stimulated 或 22 (R)-hydroxycholesterol-induced 睾丸激素生产上的 GTE/EGCG 的更高的集中的禁止的效果被维持,而支持 androstenedione 的睾丸激素生产回来了控制层次。在 GTE/EGCG 的更低的集中, 22 (R)-hydroxycholesterol-supported 睾丸激素生产上的这些多酚的禁止的效果被颠倒。GTE 的禁止的效果可以被它一个 gallate 组的主要部件, EGCG,和存在的行动在它的结构解释在禁止睾丸激素生产为它的高功效似乎重要。位于 GTE 和 EGCG 的效果下面的机制包含表明 P450 方面链劈开酶和 17-hydroxysteroid 脱氢酶功能的小径,以及抑制的 PKA/PKC 的抑制。 | Marina S. Figueiroa Juliany S. B. Cesar Vieira Disleide S. Leite Ruben C. O. Andrade Filho Fabiano Ferreira Patricia S. Gouveia Daniel P. Udrisar Maria I. Wanderley | 2009 | Asian Journal of Andrology2009，11，3： | 4 |
| 15 | 经颅直流电刺激对痛觉过敏的逆转显示文摘神经性疼痛的出现来自周围和中枢神经损伤,并且包含明显的临床症状和经常使人呈现衰弱的状态。以往的研究表明,经颅直流电刺激(tDCS)在其他疼痛试验模型中能够影响疼痛的传输,此研究旨在探究 tDCS 在神经性疼痛(NP)模型中对疼痛和细胞因子影响。 | 陆晶晶 顾旭东 Cioato SG Medeiros LF Marques Filho PR | 2016 | 中国康复2016，31，5： | 4 |
| 16 | Brainstem gliomas--retrospective analysis of 86 patients显示文摘 | Ueoka DI Nogueira J Campos JC Maranhao Filho P Ferman S Lima MA | 2009 | 中国神经肿瘤杂志2009，7，3： | 3 |
| 17 | ABC transporters and the hallmarks of cancer:roles in cancer aggressiveness beyond multidrug resistance显示文摘The ATP-binding cassette transporters(ABC transporters)have been intensely studied over the past 50 years for their involvement in the multidrug resistance(MDR)phenotype,especially in cancer.They are frequently overexpressed in both naive and post-treatment tumors,and hinder effective chemotherapy by reducing drug accumulation in cancer cells.In the last decade however,several studies have established that ABC transporters have additional,fundamental roles in tumor biology;there is strong evidence that these proteins are involved in transporting tumor-enhancing molecules and/or in protein-protein interactions that impact cancer aggressiveness,progression,and patient prognosis.This review highlights these studies in relation to some well-described cancer hallmarks,in an effort to re-emphasize the need for further investigation into the physiological functions of ABC transporters that are critical for tum or development.Unraveling these new roles offers an opportunity to define new strategies and targets for therapy,which would include endogenous substrates or signaling pathways that regulate these proteins. | Wanjiru Muriithi Lucy Wanjiku Macharia Carlos Pilotto Heming Juliana Lima Echevarria Atunga Nyachieo Paulo Niemeyer Filho Vivaldo Moura Neto | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 18 | Interference of iron as a coagulant on MIB removal by powdered activated carbon adsorption for low turbidity waters显示文摘Powered activated carbon (PAC) is widely used in water treatment plants to minimize odors in drinking water. This study investigated the removal of 2-methylisoborneol (MIB) by PAC adsorption, combined with coagulation using iron as a coagulant. The adsorption and coagulation process were studied through different case scenarios of jar tests. The analysis evaluated the effect of PAC dosing in the liquid phase immediately before or after the coagulant addition. Ferric sulphate was used as the coagulant with dosages from 10 to 30 mg/L, and PAC dosages varied from 10 to 40 mg/L. The highest MIB removal efficiency (about 70%) was achieved without the coagulant addition and with the highest PAC dosage (40 mg/L). Lower MIB removal efficiencies were observed in the presence of coagulant, showing a clear interference of the iron precipitate or coagulant in the adsorption process. The degree of interference of the coagulation process in the MIB removal was proportional to the ratio of ferric hydroxide mass to the PAC mass. For both cases of PAC dosing, upstream and downstream of the coagulant injection point, the MIB removal efficiency was similar. However, MIB removal efficiency was 15% lower when compared with experiments without the coagulant application. This interference in the MIB adsorption occurs potentially because the coagulant coats the surface of the carbon and interferes with the MIB coming in contact with the carbon's surface and pores. This constraint requires an increase of the PAC dosage to provide the same efficiency observed without coagulation. | Ferreira Filho SIDNEY SECKLER Marchetto MARGARIDA Alves Laganaro ROSEMEIRE | 2013 | Journal of Environmental Sciences2013，25，8： | 3 |
| 19 | 影像学评估慢性便秘及其外科治疗策略价值显示文摘评估慢性便秘的常用方法包括结肠传输试验、排粪造影和盆腔动态磁共振检查,用以鉴别慢传输型便秘和出口梗阻型便秘。这些检查方法具有微创、安全,技术上比较简单等特点,但由于受检者射线或检查设备的昂贵使其应用收到一定限制。动态肛管直肠超声成像技术和超声排粪成像技术(echodefecography)作为一项新近开展的诊断技术,能够对后盆底内所有功能异常状态进行有效评估,同时避免射线损伤。 | Regadas FSP Lima DMR Murad-Regadas SM Regadas Filho FSP 徐晓东(译) 傅传刚(审校) | 2013 | 中国实用外科杂志2013，33，11： | 3 |
| 20 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员