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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Disulfide connectivity prediction using secondary strueture information and diresidue frequeneies显示文摘 | F Ferre and P Clote | 2005 | Bioinformatics2005，21，10： | 1 |
| 3 | PCR method and application显示文摘 | | 1992 | Biotechniques1992，2，： | 1 |
| 4 | New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose :a role for the transcription factor sterol regulatory element binding protein-1 c 显示文摘 | Foufelle F Ferre P | 2002 | Biochem J2002，366，2： | 1 |
| 5 | Study of the clinical and epidemiological characteristics of respiratory infections caused by adenovirus in a pediatric population (1997-2003)显示文摘 | Reina J Ferres F Gutierrez O | 2004 | An Pediatr (Barc)2004，61，2： | 1 |
| 6 | Protein kinase C alpha is required for endothelin-1-induced proliferation of human myometrial cells显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Reprod2002，66，： | 1 |
| 7 | The FRU1TFULL MADS-box gene mediates cell differentia- tion during Arabidopsis fruit development 显示文摘 | GU Q FERR~NDIZ C YANOFSKY M F | 1998 | Develop- ment1998，125，： | 1 |
| 8 | Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain显示文摘 | Ferre S Ciruela F Borycz J | 2008 | Front Biosci2008，13，： | 1 |
| 9 | The VIRGO study:nevirapine,didanosine and stavudine combination therapy in antiretroviral-naive HIV-l-infected adults显示文摘 | Raffi F Reliquet V Ferré V | | 0，，： | 1 |
| 10 | ADD-I/SREBP-I is a major determinant of tissue differential lipogenic capacity in mammalian and avian species 显示文摘 | GONDRET F FERRE P QUGAIL I | 2001 | The Journal of Lipid Research2001，42，： | 1 |
| 11 | Phenolic compounds from Brazilian propolis with pharmacological activities显示文摘 | Marcucci M C Ferres F Garcia-Viguera | 2001 | Journal of Ethnophamacology2001，74，： | 1 |
| 12 | Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogeneic enzymes显示文摘 | Girard J Ferre P Foufelle F | 1997 | Annu Rev Nutr1997，17，： | 1 |
| 13 | Aspirin attenuates the initiation but ont the progression of atherosclerosis in apolipoprotein E-deficlent mice fed a high-fat,high-cholesterol diel显示文摘 | Tous M Ferre N Viella E Riu f Camps J JovenJ | 2004 | Basic Clin Pharmacol Toxicol2004，95，1： | 1 |
| 14 | ADD-1/SREBP-1 is a major deter-minant of tissue differential lipogenic capacity in mammalian and a-vian species显示文摘 | Gondret F Ferre P Dugail I | 2001 | J Lipid Res2001，42，1： | 1 |
| 15 | Postnatal handling reduces emotionality ratings and accelerates two-way active avoidance in female rats显示文摘 | NUNEZ J F FERRE P GARCiA E | 1995 | Physiol Behav1995，57，5： | 1 |
| 16 | Application of unfold principal component analysis and parallel factor analysis to the exploratory analysis of olive oils by means of excitation-emission matrix显示文摘 | Guimet F Ferre J Boque R | 2004 | Analytica Chimica Acta2004，515，1： | 1 |
| 17 | Synthesis and properties of magnetite nanoparticles显示文摘 | Bentivegna F Ferré J Nyvlt M | 1998 | Appl Phys1998，83，： | 1 |
| 18 | SREBP transcription factors: master regulators of lipid homeo-stasis显示文摘 | Eberle D Hegarty B Bossard P Ferre P Foufelle F | 2004 | Biochimie2004，86，11： | 1 |
| 19 | SREBP transcription factors: master regulators of lipid homeostasis 显示文摘 | Eberle D Hegarty B Bossard P Ferre P Foufelle F | 2004 | Biochimie2004，86，11： | 1 |
| 20 | Paraoxonase-1 is associated with oxidative stress,fibrosis and FAS expression in chronic liver diseases显示文摘 | Ferré N Marsillach J Camps J Mackness B Mackness M Riu F | 2006 | J Hepatol2006，45，1： | 1 |
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