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| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | Trauma-induced alterations in macrophage function显示文摘 | Mc Carler M D Mack V E Daly T M | 1998 | Surgery1998，123，： | 2 |
| 5 | Observation of high-energy deuterium-tritium fusion gamma rays using gas Cherenkov detec- tors显示文摘 | Mack J M Berggren R R Caldwell S E | 2003 | Nucl Instrum Meth Phys Res A2003，513，56： | 1 |
| 6 | Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery显示文摘 | Leon MB Smith CR Mack M | | 0，，： | 1 |
| 7 | The effect of preoperative nutritional status on postoperative outcomes in children undergo- ing surgery for congenital heart defects in San Francisco(UCSF)and Guatemala City(UNICAR)显示文摘 | Radman M Mack R Baraoya J | 2014 | J Thorac Cardio- vasc Surg2014，147，1： | 1 |
| 8 | Pregnancy associated plasma protein A and proform eosinophilie major basic protein in the detection of different types of eomnacy artery disease显示文摘 | Hajek P Mack M Hladikova M | 2008 | Physiol Res2008，57，： | 1 |
| 9 | Serum paraoxonase after myocardial infarction 显示文摘 | Ayub A Mackness M J Arrol S | 1999 | Arterioscler Thromb Vasc Biol1999，19，1： | 1 |
| 10 | Effect of organosilicone-based adjuvants on her- bicide activity显示文摘 | Sigh M Mack R E | 1993 | Pesticide Science1993，38，23： | 1 |
| 11 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 12 | Minimally invasive and robotic surgery显示文摘 | MACK M J | 2001 | Jama2001，285，： | 1 |
| 13 | Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus infection显示文摘 | Mack M Kleinschmidt A Bruhl H | 2000 | Nat Med2000，6，7： | 1 |
| 14 | Ambient air pollution and atherosclerosis in Los Angeles 显示文摘 | Kiinzli N Jerrett M Mack W J | 2005 | Environmental Health Per- spectives2005，113，2： | 1 |
| 15 | Wedge resection versus iobectomy for stage I (T1N0M0) non-small cell lung cancer显示文摘 | Landreneau R J Sugarbaker D J Mack M J | 1997 | J Thorac Cardiovasc Surg1997，113，4： | 1 |
| 16 | Development and independent laboratory validation of a simple method for the determination of paraquat and diquat in potato, cereals and pulses显示文摘 | Kolberg D I Mack D Anastassiades M | 2012 | Anal Bioanal Chem2012，404，8： | 1 |
| 17 | Learning in a small,task-oriented, connectivist MOOC:Peda-gogical issues and implications for higher education显示文摘 | Mackness J Waite M Roberts G er al | 2013 | The International Research in Open and Distance Learning2013，，14： | 1 |
| 18 | The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | DE DIEGO M BROCCHI E MACK AY D | 1997 | Arch Virol1997，142，10： | 1 |
| 19 | Throacoscopic stapled resection for spontaneous pneumothorax显示文摘 | Hazelrigg SR Landreneau RJ Mack M | 1993 | J Thorac Cardiovasc Surg1993，105，： | 1 |
| 20 | Multiplexed gas Cherenkov detector for reaction-history measurements显示文摘 | Mack J M Caldwell S E Evans S C | 2006 | Rev Sci Instrum2006，77，10： | 1 |
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