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| 1 | How could pharmacogenomies help improve patient survival 显示文摘 | Rosell R Felip E Paz:res L | 2007 | Lung Cancer2007，57，2： | 1 |
| 2 | How could pharmaeogenomies help improve patient survival 显示文摘 | Rosell R Felip E Paz-Ares L | 2007 | Lung Cancer2007，57，2： | 1 |
| 3 | Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers显示文摘AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers.METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93 M diet, and animals in the experimental group received an Atkins-based diet(59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies. We expressed the data as mean ± standard deviation(sd) assuming unpaired and parametric data; we analyzed differences using the student's t-test. statistical significance was set at P < 0.05.RESULTS: We found that plasma alanine aminotransferase and aspartate aminotransferase levels were significantly higher in the experimental group than in the control group. According to flow cytometry, the percentages of nonviable cells were 11.67% ± 1.12% for early apoptosis, 12.07% ± 1.11% for late apoptosis, and 7.11% ± 0.44% for non-apoptotic death in the experimental diet group and 3.73% ± 0.50% for early apoptosis, 5.67% ± 0.72% for late apoptosis, and 3.82% ± 0.28% for non-apoptotic death in the control diet group. The mean percentage of early apoptosis was higher in the experimental diet group than in the control diet group. Immunohistochemistry for autophagy was negative in both groups. sinusoidal dilation around the central vein and small hepatocytes was only observed in the experimental diet group, and fibrosis was not identified by hematoxylin-eosin or Trichrome Masson staining in either group.CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. | Maria Emília L Monteiro Analucia R Xavier Felipe L Oliveira Porphirio JS Filho Vilma B Azeredo | 2016 | World Journal of Gastroenterology2016，22，22： | 1 |
| 4 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 5 | Re- sponse surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochem- istry2003，38，8： | 1 |
| 6 | Neurofuzzy network modeling and control of steam pressure in 300MW steamboiler显示文摘 | LIU X J FELIPE L R CHAN C W | 2003 | Engineering Applications of Artificial Intelligence2003，16，56： | 1 |
| 7 | Effect of lycopene on lipid peroxidation and glutatione-dependent enzymes induced by T-2 toxin in vivo显示文摘 | Armando S Felipe R | 1999 | Toxicology Letters1999，109，： | 1 |
| 8 | Analysis and functionaL annotation of an expressed sequence tag collection for tropical crop sugarcane显示文摘 | ANDPE L V FELIPE R S EDSON L K et at | 2003 | Genome Res2003，13，： | 1 |
| 9 | How could pharmacogenomicshelp improve patient survival显示文摘 | Rosell R Felip E Paz-Ares L | 2007 | Lung Cancer2007，57，2： | 1 |
| 10 | The influence of pH,temperature and hydrolysate concentration on the removal of volatile and non-volatile compounds from sugarcane bagasse hemicellulosic hydrolysate treated with activated charcoal before or after vacuum evaporation显示文摘 | Rodrigues R C L B Felipe M G A Almeida E | 2001 | Braz J Chem Eng2001，18，： | 1 |
| 11 | How could pharmacogenomics help improve patient survival显示文摘 | ROSELL R FELIP E PAZARES L | 2007 | Lung Cancer2007，57，2： | 1 |
| 12 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables 显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochemistry2003，38，： | 1 |
| 13 | Detoxification procedures of eucalyptus hemicellulose hydrolysate for xylitol production by Candida guilliermondii显示文摘 | VILLARREAL M L M PRATA A M R FELIPE M G A | 2006 | Enzyme and Microbial Technology2006，，40： | 1 |
| 14 | Antioxidants defense and damage in senescing lupine nodules显示文摘 | Hernandes Jimenez M J Mercedes L M De Felipe M R | 2002 | Plant Physiology and Biochemistry2002，40，： | 1 |
| 15 | Model-reference adaptive control based on neuron-fuzzy networks显示文摘 | Liu X J Felipe L R Chan C W | 2004 | IEEE Trans on Systems Man & Cybernetics-Part C:Application & Review2004，34，3： | 1 |
| 16 | The posterior pediele inferior turbi- nate flap:a new vascularized flap for skull base reconstruction 显示文摘 | Felipe S G Fortes R L Carrau | 2007 | The lyngoscope2007，117，8： | 1 |
| 17 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables 显示文摘 | Rodrigues R C L B Felipe M G A Almeida e Silva J B Vitolo M | 2003 | Process Biochemistry2003，38，8： | 1 |
| 18 | How could pharmacogenomics help improve patient survival显示文摘 | Rosell R Felip E Paz Ares L | 2007 | Lung Cancer2007，57，2： | 1 |
| 19 | 5-lump kinetic model for gas oil catalytic cracking显示文摘 | JORGE A J FELIPE L I ENRIQUE A R | 1999 | Applied Catalysis A:General1999，117，2： | 1 |
| 20 | Fullerenes in the Cretaceous-Tertiary Boundary Layer 显示文摘 | D Heymann L P Felipe Chibante R R Brooks | 1994 | Science1994，265，29： | 1 |
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