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| 1 | Clinical Application of Chromosome Microarray Analysis in Han Chinese Children with Neurodevelopmental Disorders显示文摘Chromosome microarray analysis(CMA) is a cost-effective molecular cytogenetic technique that has been used as a first-line diagnostic test in neurodevelopmental disorders in the USA since 2011. The impact of CMA results on clinical practice in China is not yet well studied, so we aimed to better evaluate this phenomenon.We analyzed the CMA results from 434 patients in our clinic, and characterized their molecular diagnoses, clinical features, and follow-up clinical actions based on these results. The overall diagnostic yield for our patients was 13.6%(59 out of 434). This gave a detection rate of 14.7%for developmental delay/intellectual disability(DD/ID,38/259) and 12% for autism spectrum disorders(ASDs,21/175). Thirty-three recurrent(n≥2) variants were found, distributed at six chromosomal loci involving known chromosome syndromes(such as DiGeorge, Williams Beuren, and Angelman/Prader-Willi syndromes).The spectrum of positive copy number variants in our study was comparable to that reported in Caucasian populations, but with specific characteristics. Parental origin tests indicated an effect involving a significant maternal transmission bias to sons. The majority of patients with positive results(94.9%) had benefits, allowing earlier diagnosis(36/59), prioritized full clinical management(28/59), medication changes(7/59), a changed prognosis(30/59), and prenatal genetic counseling(15/59). Our results provide information on de novo mutations in Chinese children with DD/ID and/or ASDs. Our data showed that microarray testing provides immediate clinical utility for patients. It is expected that the personalized medical care of children with developmental disabilities will lead to improved outcomes in long-term developmental potential.We advocate using the diagnostic yield of clinically actionable results to evaluate CMA as it provides information of both clinical validity and clinical utility. | Mingyu Xu Yiting Ji Ting Zhang Xiaodong Jiang Yun Fan Juan Geng Fei Li | 2018 | Neuroscience Bulletin2018，34，6： | 8 |
| 2 | Gap-surface plasmon metasurfaces for linear-polarization conversion, focusing,and beam splitting显示文摘Gap-surface plasmon(GSP)metasurfaces have attracted progressively increasing attention due to their planar configurations,ease of fabrication,and unprecedented capabilities in manipulating the reflected fields that enable integrating diverse bulk-optic-based optical components into a single ultrathin flat element.In this work,we design and experimentally demonstrate multifunctional metalenses that perform simultaneous linear-polarization conversion,focusing,and beam splitting,thereby reproducing the combined functionalities of conventional halfwave plates,parabolic reflectors,and beam splitters.The fabricated single-focal metalens incorporates properly configured distinct half-wave-plate-like GSP meta-atoms and exhibits good performance under linearly polarized incidence in terms of orthogonal linear-polarization conversion(>75%)and focusing(overall efficiency>22%)in the wavelength spectrum ranging from 800 to 950 nm.To further extend the combined functionalities,we demonstrate a dual-focal metalens that splits and focuses a linearly polarized incident beam into two focal spots while maintaining the capability of orthogonal linear-polarization conversion.Furthermore,the power distribution between two split beams can readily be controlled by judiciously positioning the incident beam.The demonstrated multifunctional GSP-based metalenses mimic the combined functionalities of a sequence of discrete bulk optical components,thereby eliminating the need for their mutual alignment and opening new perspectives in the development of ultracompact and integrated photonic devices. | FEI DING YITING CHEN SERGEY IBOZHEVOLNYI | 2020 | Photonics Research2020，8，5： | 5 |
| 3 | Study on phase diagram of BieOa-SiO2 system for bridgman growth of BiiSiaOte single crystal显示文摘 | Yiting Fei Shiji Fan Renying Sun | 2000 | Progress in Crystal Growth and Characterization of Materials2000，40，： | 1 |
| 4 | Study on phase diagram of Bi203-SiO2 system for Bridgman growth of Bi4Si3Ol2 single crystal显示文摘 | FEI Yiting FAN Shiji SUN Renying | 2000 | Prog Cryst Growth Charaet Mater2000，40，14： | 1 |
| 5 | Crystallizing behavior of Bi203-SiO2 system显示文摘 | FEI Yiting FAN Shiji SUN Renying | 2000 | J Mater Sci Lett2000，19，10： | 1 |
| 6 | Hightemperature piezoelectric single crystal ReCa4O(BO3)3for sensor applications显示文摘 | ZHANG Shujun FEI Yiting FRANTZ E | 2008 | Ultrasonics Ferroelectrics and Frequency Control2008，55，12： | 1 |
| 7 | Characterization of piezoelectric single crystal YCa4O(BO3)3for high temperature applications显示文摘 | ZHANG Shujun FEI Yiting CHAI B H T | 2008 | Applied Physics Letters2008，92，20： | 1 |
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