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您的检索式：作者名="FATIMA Wasim"
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| 1 | Synthesis and Structural Investigations of New 4-Hexyl-1-(4-nitrophenyl)-1-H-1,2,3-triazole:An Experimental and Theoretical Insight显示文摘The title compound,4-hexyl-l-(4-nitrophenyl)-l-H-1,2,3-triazole(C14H18N4O2),was synthesized using one-pot strategy via click reaction and the structure was characterized mainly by single-crystal X-ray diffraction,NMR,FT-IR and MS.C14H18N4O2 was crystallized from an EtOH/EtOAc solution in triclinic system,space group P1,with α = 5.3679(3),b = 7.5499(5),c =17.5534(11) A,α = 92.360(4),β = 90.359(4),γ = 98.864(4)°,V(A3) = 702.24(8),Z = 2,crystal size(mm) = 0.42 × 0.26 × 0.18,Rint = 0.096.Packing diagram indicates that there is dimeric interaction between two units via N(3)…H(6).The crystal structure of the title compound(1) is stabilized by intermolecular interactions.In addition,X-ray analysis also reveals C-H…π and π-π interactions in the molecule.Theoretical investigations were performed by using Gaussian 09 software at the B3LYP/6-31G(d,p) level of density finctional theory(DFT) to compare the theoretical results with the experimental and to probe structural properties.The molecular electrostatic potential(MEP) mapped over the entire stabilized geometry of the molecule indicated their chemical reactivities.Furthermore,frontier molecular orbital(electronic properties) was computed at the same level of DFT as used for energy minima structure. | MUHAMMAD Naeem Ahmed KHAWAJA Ansar Yasin TARIQ Mahmood FATIMA Wasim MUHAMMAD Haleem Khan M.NAWAZ Tahir SAFEENA Zafar SHAISTA Anjum | 2015 | Chinese Journal of Structural Chemistry2015，34，12： | 0 |
| 2 | Is transarterial embolization a valuable treatment option for spontaneous rupture of hepatocellular carcinoma: experience from a tertiary care hospital of South-Asia显示文摘Aim:Transarterial embolization(TAE)has been found beneficial in treatment of ruptured Hepatocellular carcinoma(HCC)in earlier studies.So far no data is available from Pakistan.The aim of this study was to evaluate clinicopathological characteristics,outcomes of patients presented with spontaneously ruptured,unresectable HCC treated with or without TAE and to evaluate the factors associated with 30-day mortality.Methods:This was a cross sectional study.Patients≥18 years old,presented with spontaneous rupture of unresectable HCC,were evaluated.The outcome measures were control of bleeding,in-hospital mortality,30-day mortality and factors associated with 30-days mortality.Results:Out of 850 patients,24 patients were diagnosed with spontaneously ruptured HCC.Mean age was 58.29±15.26 years.A total of 11(45.8%)patients were treated conservatively and 13(54.2%)underwent TAE.Control of bleeding due to ruptured HCC was significantly higher for those treated via TAE as compared to those who were treated conservatively(92.3%vs.36.4%,P=0.008).Overall median duration for which the patients remained alive after HCC rupture was longer for TAE group(39 days vs.5 days,P=0.03).In-hospital mortality(30.8% vs.72.7%,P=0.04)and 30-day mortality was also lower in TAE group(38.5%vs.90.9%,P=0.01).Those who underwent TAE had lower risk of mortality then conservative group odds ratio(OR)0.25,95% confidence interval(CI0.07-0.90,P=0.03).Failure to control bleeding was associated with higher 30-day mortality(OR 2.14,95% CI 1.24-3.68,P=0.009).Conclusion:Ruptured HCC is a life threatening complication requiring early diagnosis and treatment.TAE is an effective and well-tolerated treatment in the management of ruptured HCC. | Amna Subhan Butt Saeed Hamid Nazish Butt Fatima Sharif Tanveer Ul Haq Wasim Jafri | 2016 | Hepatoma Research2016，2，1： | 0 |
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